| Secret Ties | US | 1992 |
Tokai Engineering | Prototype |
| Secret of Grimshire | WORLD | |
| Unlicensed |
| Section-Z | EU | 1989-09-27 |
Capcom | Commercial |
| Section-Z | US | 1987-07 |
Capcom | Commercial |
| Seicross | JP | 1986-05-15 |
Pony Canyon | Commercial |
| Seicross | JP | 1986-05-15 |
Pony Canyon | Demo |
| Seicross | US | 1988-10 |
Pony Canyon | Commercial |
| Seikima II - Akuma no Gyakushuu! | JP | 1986-12 |
CBS Sony Group | Commercial |
| Seirei Densetsu Lickle | JP | 1992-06-26 |
Taito | Commercial |
| Seirei Gari | JP | 1989-12-08 |
Hudson Soft | Commercial |
| Seiryaku Simulation - Inbou no Wakusei - Shancara | JP | 1992-06 |
IGS | Commercial |
| Sekiryuuou | JP | 1989-02 |
Sunsoft | Commercial |
| Senjou no Ookami | JP | 1986-09 |
Capcom | Commercial |
| Senseless City | WORLD | 2022-10 |
Rani Baker | Unlicensed |
| Senseless City - Space Jesus | WORLD | 2023-03 |
Rani Baker | Demo |
| Sensha Senryaku - Sabaku no Kitsune | JP | 1988-04-28 |
Kemco | Commercial |
| Sensible Soccer | EU | 1993 |
Sony Imagesoft | Prototype |
| Sesame Street - 123 | US | 1989-01 |
HiTech Software | Commercial |
| Sesame Street - ABC | US | 1989-09 |
HiTech Software | Commercial |
| Sesame Street - ABC & 123 | US | 1991-11 |
HiTech Software | Commercial |
| Sesame Street - Big Bird's Hide & Speak | US | 1990-10 |
HiTech Software | Commercial |
| Sesame Street - Countdown | US | 1992-02 |
HiTech Software | Commercial |
| Sesame Street - Countdown | US | 1992-02 |
HiTech Software | Prototype |
| Sgt. Helmet Training Day | EU | 2013 |
The Mojon Twins | Unlicensed |
| Sgt. Helmet Training Day | US | 2013 |
The Mojon Twins | Unlicensed |
| Shadow - An Adventure in Monochrome | WORLD | |
| Unlicensed |
| Shadow Brain | JP | 1991-03-21 |
Pony Canyon | Commercial |
| Shadow Warriors - Ninja Gaiden | EU | 1988-12 |
Tecmo | Commercial |
| Shadow Warriors II - Ninja Gaiden II | EU | 1990-04 |
Tecmo | Commercial |
| Shadow of the Ninja | EU | 1991-07-25 |
Taito | Commercial |
| Shadow of the Ninja | US | 1990-12 |
Taito | Commercial |
| Shadow of the Ninja | US | 1990-12 |
Natsume | Demo |
| Shadowgate | DE | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | EU | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | FR | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | JP | 1989-03-31 |
Kemco | Commercial |
| Shadowgate | JP | 1989-03-31 |
Kemco | Prototype |
| Shadowgate | SE | 1991-05-30 |
Kemco | Commercial |
| Shadowgate | US | 1989-12 |
Kemco | Commercial |
| Shadowgate | US | 1989-12 |
Kemco | Demo |
| Shadowgate | WORLD | 1989-03-31 |
Kemco | Commercial |
| Shanggu Shen Jian | CN | |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Shanggu Shendian | CN | |
| Unlicensed |
| Shanghai | JP | 1987-12-04 |
Sunsoft | Commercial |
| Shanghai | JP | 1987-12-04 |
Sunsoft | Demo |
| Shanghai II | JP | 1990-08-24 |
Sunsoft | Commercial |
| Shanghai Tycoon | CN | |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Shanshan de Hongxing | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Shaonian Youxia - Guangming Zhi Shen | CN | |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Sharinman | WORLD | |
| Unlicensed |
| Shatterhand | EU | 1992-11-19 |
Jaleco | Commercial |
| Shatterhand | US | 1991-12 |
Jaleco | Commercial |
| Shatterhand | US | 1991-12 |
Jaleco | Prototype |
| She Diao Yingxiong Zhuan | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Shen Gui Chuanqi | CN | |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Shen Mo Dalu | CN | |
| Unlicensed |
| Sheng Doushi | CN | |
| Unlicensed |
| Sheng Doushi Xingshi - Beiou Tuji Pian | CN | |
| Unlicensed |
| Sheng Doushi Xingshi - Shikong Doushi | CN | |
| Unlicensed |
| Sheng Doushi Xingshi - Tianma Zhi Huanxiang | CN | |
| Unlicensed |
| Sheng Huo Lie Zhuan | CN | 1991 |
Computer & Entertainment | Unlicensed |
| Sheng Huo Lie Zhuan | TW | 1991 |
Computer & Entertainment | Unlicensed |
| Sheng Jian Chuanshuo | CN | |
| Unlicensed |
| Shenghua Weiji - Bio Hazard | CN | 2003 |
| Unlicensed |
| Shenghuo Huizhang - Sofia Fusu | CN | |
| Unlicensed |
| Shenghuo Huizhang II | CN | |
| Unlicensed |
| Shenghuo Huizhang III | CN | |
| Unlicensed |
| Shenghuo Huizhang Waizhuan | CN | 1997 |
| Unlicensed |
| Shenghuo Shao Xia | CN | |
| Unlicensed |
| Shenhua Jian Yun | CN | |
| Unlicensed |
| Shenqi Baobei | CN | |
| Unlicensed |
| Shenqi Si Xia | CN | |
| Unlicensed |
| Shentan Kenan | CN | 1991-02 |
King Records | Unlicensed |
| Shera and the 40 Thieves | WORLD | 2021-05 |
CrazyGroupTrio Games | Unlicensed |
| Shera and the 40 Thieves - Definitive Edition | WORLD | 2023-09 |
crazygrouptrio | Demo |
| Sherlock Holmes - Hakushaku Reijou Yuukai Jiken | JP | 1986-12 |
Towa Chiki | Commercial |
| Shikinjou | JP | 1991-04 |
Toei Animation | Commercial |
| Shiluo de Shenqi | CN | |
| Unlicensed |
| Shin 4 Nin Uchi Mahjong - Yakuman Tengoku | JP | 1991-06-28 |
Nintendo | Commercial |
| Shin Jinrui - The New Type | JP | 1987-02-10 |
Hudson Soft | Commercial |
| Shin Moero!! Pro Yakyuu | JP | 1989-07 |
Jaleco | Commercial |
| Shin Samurai Spirits 2 - Haoumaru Jigoku Hen | TW | 1996 |
| Unlicensed |
| Shin Satomi Hakken-Den - Hikari to Yami no Tatakai | JP | 1989-12 |
Toei Animation | Commercial |
| Shingen the Ruler | US | 1990-06 |
Hot-B | Commercial |
| Shinobi | US | 1989-12 |
Tengen | Unlicensed |
| Shinsenden | JP | 1989-12-15 |
Irem | Commercial |
| Shiqi Shidai | CN | |
| Unlicensed |
| Shisen Mahjong - Seifuku Hen | JP | 1989 |
Hacker International | Unlicensed |
| Shisen Mahjong 2 | TW | 1996 |
Trump Grand Manufacturing | Unlicensed |
| Shishang Tiaowutan | CN | |
| Unlicensed |
| ShmupSpeed | WORLD | 2018-11 |
Gloves | Unlicensed |
| Shockwave | US | 1991 |
American Game Cartridges | Unlicensed |
| Shogun | JP | 1988-05-27 |
HectorSoft | Commercial |
| Shokan Doro Beginning | WORLD | |
| Demo |
| Shoot the Goof | AS | |
| Unlicensed |
| Shooting Range | US | 1989-06 |
Bandai Namco | Commercial |
| Short Order + Eggsplode! | US | 1989-12 |
Nintendo | Commercial |
| Shouen no Kishi - Durandal | WORLD | |
| Unlicensed |
| Shougi Meikan '92 | JP | 1992-01 |
HectorSoft | Commercial |
| Shougi Meikan '93 | JP | 1992-12 |
HectorSoft | Commercial |