| U-Force Power Games | US | 1990 |
TOSE | Prototype |
| U.S. Championship V'Ball | JP | 1989-11 |
Nintendo | Commercial |
| U.S. Championship V'Ball | JP | 1989-11 |
Nintendo | Demo |
| UFO Invaders | WORLD | 2023-10 |
Raftronaut | Unlicensed |
| UFO Sighted! | WORLD | |
| Prototype |
| USA Ice Hockey in FC | JP | 1993-03-06 |
Jaleco | Commercial |
| UWC | US | 1989 |
SETA | Prototype |
| Uchuu Keibitai SDF | JP | 1990-09 |
HAL Laboratory | Commercial |
| Uchuusen Cosmo Carrier | JP | 1987-11 |
Jaleco | Commercial |
| Ufouria - The Saga | EU | 1992-11-19 |
Sunsoft | Commercial |
| Ufouria - The Saga | EU | 1992-11-19 |
Sunsoft | Prototype |
| Ufouria - The Saga | US | 1991-09 |
Sunsoft | Prototype |
| Ufouria - The Saga | US | 1991-09 |
Sunsoft | Commercial |
| Ufouria - The Saga | WORLD | 1991-09-20 |
Sunsoft | Commercial |
| Ugadayka | RU | 1995 |
A. Chudov | Unlicensed |
| Ultima - Exodus | US | 1989-02 |
FCI | Commercial |
| Ultima - Kyoufu no Exodus | JP | 1987-10 |
FCI | Commercial |
| Ultima - Quest of the Avatar | US | 1990-12 |
FCI | Commercial |
| Ultima - Seija e no Michi | JP | 1989-09 |
FCI | Commercial |
| Ultima - Warriors of Destiny | US | 1993-01 |
FCI | Commercial |
| Ultimate Air Combat | EU | 1992-11 |
Activision | Commercial |
| Ultimate Air Combat | EU | 1992-11 |
Activision | Prototype |
| Ultimate Air Combat | US | 1992-04 |
Activision | Commercial |
| Ultimate Air Combat | US | 1992-04 |
Activision | Prototype |
| Ultimate Basketball | US | 1990-09 |
Sammy | Commercial |
| Ultimate Frogger Champion | WORLD | 2009-05 |
retroUSB | Unlicensed |
| Ultimate Frogger Champion | WORLD | 2009-05 |
retroUSB | Demo |
| Ultimate League Soccer | EU | 1991 |
American Video Entertainment | Unlicensed |
| Ultimate League Soccer | US | 1992 |
American Video Entertainment | Unlicensed |
| Ultimate Mortal Kombat 3 | TW | 1996 |
| Unlicensed |
| Ultimate Mortal Kombat 4 | TW | 1996 |
| Unlicensed |
| Ultraman Club - Kaijuu Daikessen!! | JP | 1992-12 |
Angel | Commercial |
| Ultraman Club - Supokon Fight! | JP | 1993-04 |
Bandai | Commercial |
| Ultraman Club 2 - Kaettekita Ultraman Club | JP | 1990-04 |
Bandai | Commercial |
| Ultraman Club 3 - Matamata Shutsugeki!! Ultra Kyoudai | JP | 1991-12 |
Yutaka | Commercial |
| Uncharted Waters | US | 1991-11 |
Koei | Commercial |
| Undercover Shot | WORLD | 2025-03 |
Pirate Princess Games | Unlicensed |
| Underground Adventure | WORLD | 2019 |
| Demo |
| Underground Mission | CN | |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Uninvited | US | 1991-06 |
Kemco | Commercial |
| Uninvited | US | 1991-06 |
Kemco | Prototype |
| Uninvited | WORLD | 1989-09-29 |
Kemco | Commercial |
| Unknown Soldier | WORLD | |
| Unlicensed |
| Untitled Platformer | WORLD | |
| Prototype |
| Upsad Down | WORLD | 2021-02 |
Fadest | Prototype |
| Urban Champion | AS | 1984-11-14 |
| Unlicensed |
| Urban Champion | US | 1986-08 |
Nintendo | Commercial |
| Urban Champion | WORLD | 1984-11-14 |
Nintendo | Commercial |
| Urban Strike | AS | 1995 |
| Unlicensed |
| Urusei Yatsura - Lum no Wedding Bell | JP | 1986-10-23 |
Jaleco | Commercial |
| Urusei Yatsura - Lum no Wedding Bell | JP | 1986-10-23 |
Jaleco | Prototype |
| Ushio to Tora - Shinen no Taiyou | JP | 1993-07 |
Yutaka | Commercial |
| Utaco | WORLD | 2015-03 |
Miguel | Unlicensed |
| Utsurun Desu. - Kawauso Hawaii e Iku | JP | 1992-03-06 |
Takara | Commercial |
| UtwoPia | WORLD | |
| Demo |