| E.T. - The Extra Terrestrial | US | 2014 |
KHAN Games | Unlicensed |
| E.T. - The Extra Terrestrial | WORLD | 2014 |
KHAN Games | Unlicensed |
| Earth Soldier - Happy Bichi | CN | 1996 |
| Unlicensed |
| EarthBound Beginnings | EU | 1989-07 |
Nintendo | Commercial |
| EarthBound Beginnings | US | 1989-07 |
Nintendo | Commercial |
| Earthworm Jim 2 | TW | 1996 |
Shin-Shin | Prototype |
| Earthworm Jim 2 | TW | 1996 |
Hosenkan Electronics | Unlicensed |
| Earthworm Jim 3 | TW | 1997 |
| Unlicensed |
| Echoes of Elysium Descent | WORLD | |
| Demo |
| Educational Computer 2000 - 48-in-1 | ES | |
| Unlicensed |
| Eelectric | WORLD | 2021-09 |
Wendel Scardua | Unlicensed |
| Egg World | WORLD | 2023-01 |
| Prototype |
| Eggerland - Meikyuu no Fukkatsu | JP | 1988-08 |
HAL Laboratory | Commercial |
| Egypt | JP | 1991-05-31 |
Human | Commercial |
| El Bloque Magico | ES | 1991 |
NTDEC | Unlicensed |
| El Destructor | ES | 1992 |
Gluk | Unlicensed |
| El Monstruo de los Globos | ES | 1991 |
NTDEC | Unlicensed |
| Electric Dragon - Another World | WORLD | 2022-07 |
Neodolphino Productions | Prototype |
| Electric Dragon - Another World | WORLD | 2022-07 |
Neodolphino Productions | Unlicensed |
| Elemental | WORLD | |
| Unlicensed |
| Elevator Action | AS | 1985-06-28 |
| Unlicensed |
| Elevator Action | JP | 1985-06-28 |
Taito | Commercial |
| Elevator Action | TW | 1985-06-28 |
| Unlicensed |
| Elevator Action | US | 1987-08 |
Taito | Commercial |
| Elfland | TW | 1993 |
JungleTac | Unlicensed |
| Eliminator Boat Duel | EU | 1993-04-29 |
Storm | Commercial |
| Eliminator Boat Duel | US | 1991-11 |
Storm | Commercial |
| Eliminator Boat Duel | WORLD | 1991-11 |
Electro Brain | Commercial |
| Elite | EU | 1991 |
Imagineer | Commercial |
| Elite | EU | 1991 |
Imagineering | Prototype |
| Elite | WORLD | 1991 |
Imagineer | Unlicensed |
| Elnark no Zaihou | JP | 1987-08-10 |
Towa Chiki | Commercial |
| Elusion of the Dead | WORLD | |
| Prototype |
| Elysion | JP | 1988-04-28 |
Tokuma Shoten | Commercial |
| Ember Hollow | WORLD | |
| Demo |
| Emoyan no 10 Bai Pro Yakyuu | JP | 1989-12 |
HectorSoft | Commercial |
| English, Pyramid | KR | 1989 |
Sachen | Unlicensed |
| Enigmacore | US | 2015 |
K3VBOT | Unlicensed |
| Enter Password | WORLD | |
| Unlicensed |
| Eric Cantona Football Challenge - Goal! 2 | EU | 1992-11-15 |
Jaleco | Commercial |
| Erika to Satoru no Yume Bouken | JP | 1988-09 |
Namco | Commercial |
| Erzhan Zhi Jingdian Zhanyi | CN | |
| Unlicensed |
| Escape from Flooded Ruins | WORLD | 2021-02 |
| Unlicensed |
| Escape from Paradise | WORLD | |
| Unlicensed |
| Espanol de Estudo - 32-in-1 | ES | |
| Unlicensed |
| Esper Bouken Tai | JP | 1987-10 |
Konami | Commercial |
| Esper Dream 2 - Aratanaru Tatakai | JP | 1992-06 |
Konami | Commercial |
| Espitene | WORLD | 2017 |
The Mojon Twins | Unlicensed |
| Espitenen und Herr Pimponen | WORLD | 2019-09 |
The Mojon Twins | Unlicensed |
| Et Tu | WORLD | |
| Unlicensed |
| Euchre | WORLD | 2018 |
| Unlicensed |
| Even Goblins - Fall in Love | WORLD | |
| Demo |
| EverQuest - Ba Bao Qizhu | CN | |
| Unlicensed |
| EverQuest - Wujin de Renwu | CN | 1999 |
| Unlicensed |
| Evil Incarnate | WORLD | |
| Unlicensed |
| Excitebike | AS | 1984-11-30 |
| Unlicensed |
| Excitebike | EU | 1986-09-01 |
Nintendo | Commercial |
| Excitebike | JP | 1984-11-30 |
Nintendo | Commercial |
| Excitebike | US | 1985-10-18 |
Nintendo | Commercial |
| Excitebike | WORLD | 1984-11-30 |
Nintendo | Commercial |
| Exciting Basket | AS | 1987-07 |
| Unlicensed |
| Exciting Boxing | JP | 1987-12-16 |
Konami | Commercial |
| Exciting Rally - World Rally Championship | JP | 1992-04-24 |
HAL Laboratory | Commercial |
| Exciting Soccer - Konami Cup | AS | |
| Unlicensed |
| Exerion | JP | 1985-02-11 |
Taito | Commercial |
| Exerion | TW | 1985-02-11 |
| Unlicensed |
| Exerion II | US | 2009 |
| Unlicensed |
| Exerion II | US | 2009 |
Retrozone | Prototype |
| Exodus - Journey to the Promised Land | US | 1991 |
Wisdom Tree | Unlicensed |
| Exploding Fist | US | 1990 |
Tradewest | Commercial |
| Exploding Fist | US | 1990 |
Tradewest | Prototype |
| Exploding Fist | WORLD | 1990 |
Tradewest | Commercial |