| Shadow Warriors - Ninja Gaiden | 1988 | nes |
| Shadow of the Beast | 1991 | genesis, pcengine |
| Shadow of the Beast - Mashou no Okite | 1992 | genesis |
| Shadow of the Beast - Mashou no Okite | 1992 | pcengine |
| Shadow of the Beast II | 1992 | genesis |
| Shadow of the Beast II | 1994 | segacd |
| Shadow of the Beast II - Juushin no Jubaku | 1994 | segacd |
| Shadow of the Ninja | 1990 | nes |
| A Shadow's Tale | 2010 | wii |
| Shadowhawk | | snes |
| Shadowland | 1987 | arcade |
| Shadows of the Wind | | genesis |
| Shady Part of Me | 2020 | ps4 |
| Shaman King - Master of Spirits 2 | 2005 | gba |
| Shantae | 2002 | gbc, nds, ps4, switch |
| Shantae - Half-Genie Hero | 2016 | ps4, switch, vita, wiiu, xboxone |
| Shantae Advance - Risky Revolution | 2024 | gba, ps4, switch, xboxone |
| Shantae: Risky's Revenge | 2015 | ps4 |
| Shape Shifter | 1992 | pcengine |
| Shark Tale | 2004 | gba |
| Shatterhand | 1991 | nes |
| Shengui Diguo Zhi Emo Cheng | 2003 | gbc |
| Shenqi Jiqi Jingjichang - Bibohou Zhongji Rezhan | 2004 | ps2 |
| Shera and the 40 Thieves | 2021 | nes |
| Shera and the 40 Thieves - Definitive Edition | 2023 | nes |
| Shift Happens | 2017 | ps4, xboxone |
| Shifting World - Shiro to Kuro no Meikyuu | 2012 | 3ds |
| Shiftlings | 2015 | ps4, wiiu, xboxone |
| Shin chan Flipa en Colores! | 2007 | nds |
| Shin chan e i Colori Magici! | 2004 | nds |
| Shinobi | 1991 | gg |
| Shinobi | 1987 | arcade |
| Shinobi / FZ-2006 | 2008 | arcade |
| Shinobi II - The Silent Fury | 1992 | gg |
| Shinobi III - Return of the Ninja Master | 1993 | genesis |
| Shinobi: Art of Vengeance | 2025 | switch |
| Shiny the Firefly | 2014 | wiiu |
| Shippo de Bun | 1992 | gb |
| Shippuu! Iron Leaguer | 1994 | gb |
| Shoot for the Moon | 2023 | gba |
| Short Peace - Ranko Tsukigime's Longest Day | 2014 | ps3 |
| Shorts | 2009 | nds |
| Shovel Knight | 2014 | 3ds, ps3, ps4, switch, vita, wiiu, xboxone |
| Shovel Knight - Treasure Trove | 2014 | 3ds |
| Shrek | 2001 | gc, xbox |
| Shrek - Hassle at the Castle | 2002 | gba |
| Shrek 2 - Beg for Mercy | 2004 | gba |
| Shrek the Third | 2007 | gba, nds, psp |
| Shu | 2016 | ps4, switch, vita |
| Shuiguan Pipe | 1992 | nes |
| Sideway - New York | 2011 | ps3 |
| Sigi - A Fart for Melusina | 2018 | vita, xboxone |
| Silver Valley | | sms |
| Silverlicious | 2012 | nds |
| Simple 1500 Series Vol. 94 - The Cameraman - Gekisha Boy Omake Tsuki | 2002 | ps1 |
| The Simpsons - Bart & the Beanstalk | 1994 | gb |
| The Simpsons - Bart no Fushigi na Yume no Daibouken | 1993 | snes |
| The Simpsons - Bart no Jack to Mame no Ki | 1994 | gb |
| The Simpsons - Bart vs. the Space Mutants | 1991 | genesis, gg, nes, sms |
| The Simpsons - Bart's Nightmare | 1992 | genesis, snes |
| The Simpsons - Bartman Meets Radioactive Man | 1994 | gg |
| The Simpsons - Bartman Meets Radioactive Man | 1991 | nes |
| The Simpsons - Night of the Living Treehouse of Horror | 2001 | gbc |
| The Simpsons Game | 2007 | nds, ps2, ps3, psp, wii, xbox360 |
| Sir Ababol | 2025 | genesis |
| Sir Ababol | 2013 | nes |
| Sir Eatsalot | 2018 | vita |
| Sitafei De Chuanshuo | | gba |
| Sitafei De Chuanshuo 2 | | gba |
| SkateCat | 2023 | nes |
| Skelost | 2025 | gbc |
| Skul: The Hero Slayer | 2021 | ps4, switch, xboxone |
| Skuljagger - Revolt of the Westicans | 1992 | snes |
| Skullmonkeys | 1998 | ps1 |
| Sky Dancers - They Magically Fly! | 2005 | gba |
| SkyKeepers | 2017 | xboxone |
| SkyScrappers | 2015 | ps4 |
| Skylanders - Spyro no Daibouken | 2013 | 3ds |
| Skylanders - SuperChargers | 2015 | ps3, ps4, wiiu, xboxone |
| Skylanders - SuperChargers | 2015 | xbox360 |
| Skylanders - Swap Force | 2013 | 3ds, ps3, ps4, wii, wiiu, xbox360, xboxone |
| Skylanders - Trap Team | 2014 | ps3, xbox360 |
| Skylanders Giants | 2012 | 3ds, ps3, wii, xbox360 |
| Skylanders: Imaginators | 2016 | ps4, switch, wiiu, xbox360, xboxone |
| Sleepwalker | 1993 | cd32 |
| Slime-san Superslime Edition | 2018 | xboxone |
| Slime-san: Super Slime Edition | 2018 | ps4 |
| Slow Mole | 2021 | nes |
| Sly 2 - Band of Thieves | 2011 | ps3 |
| Sly 2 - Band of Thieves | 2014 | vita |
| Sly 3 - Honor Among Thieves | 2011 | ps3 |
| Sly 3 - Honor Among Thieves | 2014 | vita |
| The Sly Collection | 2010 | ps3 |
| Sly Cooper Collection | 2010 | ps3 |
| Sly Cooper Collection | 2010 | ps3 |
| The Sly Trilogy | 2010 | ps3 |
| The Sly Trilogy | 2014 | vita |
| Small Soldiers | 1998 | gb |
| Smart Ball | 1992 | snes |
| Smickeonn - The Game | 2024 | gb |