| Sonic X Shadows Generations | 2024 | ps4 |
| Sonic the Hedgehog | 2006 | ps3, wii, xbox360 |
| Sonic the Hedgehog 2 | 2011 | ps3 |
| Sonic the Hedgehog 4 - Episode I | 2010 | ps3 |
| Sonic the Hedgehog 4 - Episode I | 2014 | ps3 |
| Sonic the Hedgehog 4 - Episode I | 2010 | wii, xbox360 |
| Sonic the Hedgehog CD | 1993 | segacd |
| Soreyuke! Speedy Gonzales | 1994 | gb |
| Sound Shapes | 2012 | ps3, ps4, vita |
| South Park | 1999 | gbc |
| South Park - Tenorman's Revenge | 2012 | xbox360 |
| Space Ace | 1983 | arcade |
| Space Ace | 1991 | arcade |
| Space Chimps | 2008 | nds, ps2, wii, xbox360 |
| Space Funky B.O.B | 1993 | genesis, snes |
| Space Hunted | 2017 | wiiu |
| Space Hunted - The Lost Levels | | wiiu |
| Space Mutants | 2023 | nes |
| Space Mutants II | | nes |
| Space Soviets | 2023 | nes |
| Space Twins | | gba |
| SpaceStation Silicon Valley | 1998 | n64, ps1 |
| Spacegulls | 2021 | nes |
| Spacestation Silicon Valley | 1999 | gbc |
| Spanky's Quest | 1992 | gb, snes |
| Spare Parts | 2011 | ps3, xbox360 |
| Spark the Electric Jester 2 | 2020 | xboxone |
| Spartan | 2017 | xboxone |
| Spawn | 1999 | gbc |
| Spectacular Sparky | 2021 | switch |
| Speed Shoes | 2025 | nes |
| SpeedRunners | 2017 | ps4, xboxone |
| SpeedRunners | 2020 | switch |
| Speedy Gonzales | 1993 | gb |
| Speedy Gonzales - Aztec Adventure | 1999 | gbc |
| Spelunker | 1985 | nes, wiiu |
| Spelunker | 1985 | arcade |
| Spelunker Collection | 2013 | ps3, vita |
| Spelunker HD | 2009 | ps3 |
| Spelunker HD Deluxe | 2021 | switch |
| Spelunker II - 23 no Kagi | 1986 | arcade |
| Spencer | 2018 | xboxone |
| Spheroids | 2017 | vita, wiiu, xboxone |
| Spica Adventure | 2005 | arcade |
| Spider - The Video Game | 1997 | ps1 |
| Spider Maze | 1982 | a2600 |
| Spider-Man | 1995 | genesis, snes |
| Spider-Man | 1992 | gg |
| Spider-Man - Battle for New York | 2006 | gba, nds |
| Spider-Man - Mysterio's Menace | 2001 | gba |
| Spider-Man - Return of the Sinister Six | 1992 | gg, nes, sms |
| Spider-Man - Web of Shadows - Amazing Allies Edition | 2008 | ps2 |
| Spider-Man - X-Men - Arcade's Revenge | 1993 | gb |
| Spider-Man - X-Men - Arcade's Revenge | 1992 | genesis, gg, snes |
| Spider-Man 2 | 1992 | gb |
| Spider-Man 2 - The Sinister Six | 2001 | gbc |
| Spider-Man 3 - Invasion of the Spider-Slayers | 1993 | gb |
| Spider-Man: The Videogame | 1991 | arcade |
| Spike | 1983 | vectrex |
| Spin Master / Miracle Adventure | 1993 | arcade |
| Spin Tail | 1998 | ps1 |
| Spinch | 2020 | switch |
| Spiritual Guardian - Shock | | nes |
| Spirou | 1996 | gb, gg |
| Spirou | 1995 | genesis, snes |
| Spirou - The Robot Invasion | 2000 | gbc |
| Splasher | 2017 | ps4, switch, xboxone |
| SpongeBob SquarePants - Battle for Bikini Bottom | 2003 | gba |
| SpongeBob SquarePants - Creature from the Krusty Krab | 2006 | gba, nds |
| SpongeBob SquarePants - Lights, Camera, Pants! | 2005 | gba |
| SpongeBob SquarePants - Revenge of the Flying Dutchman | 2002 | gba |
| SpongeBob SquarePants - SuperSponge | 2001 | gba |
| The SpongeBob SquarePants Movie | 2004 | gba |
| Spot - Cool Adventure | 1994 | gb |
| Spot - The Cool Adventure | 1993 | gb |
| Spot Goes to Hollywood | | 32x |
| Springer | 1982 | a2600, arcade |
| Spy Kids - All the Time in the World | 2011 | nds |
| Spy Kids 3-D - Game Over | 2003 | gba |
| Spy Kids Challenger | 2002 | gba |
| Spyro - A Hero's Tail | 2004 | gc, ps2, xbox |
| Spyro - Attack of the Rhynocs | 2003 | gba |
| Spyro - Enter the Dragonfly | 2002 | gc, ps2 |
| Spyro - Season of Ice | 2001 | gba |
| Spyro 2 - Season of Flame | 2002 | gba |
| Spyro Advance | 2002 | gba |
| Spyro Advance - Wakuwaku Tomodachi Daisakusen! | 2004 | gba |
| Spyro Fusion | 2004 | gba |
| Spyro Reignited Trilogy | 2018 | ps4, switch, xboxone |
| Squinkies 2 - Adventure Mall Surprize! | 2011 | nds |
| Squirrel ~ O Esquilo | 1983 | a2600 |
| Squish and the Corrupted Crystal | 2017 | xboxone |
| Stallar | 2022 | nes |
| Standpoint | 2015 | xboxone |
| Star Trek V - The Final Frontier | 1989 | nes |
| Star Wars | 1991 | gb, gg, sms |
| Star Wars | 1993 | genesis |
| Star Wars | 1987 | nes |
| Star Wars - Episode II - Attack of the Clones | 2002 | gba |
| Star Wars - The Empire Strikes Back | 1992 | gb, nes |