| Spyro Advance | 2002 | gba |
| Spyro Advance - Wakuwaku Tomodachi Daisakusen! | 2004 | gba |
| Spyro Fusion | 2004 | gba |
| Spyro Reignited Trilogy | 2018 | ps4, switch, xboxone |
| Squinkies 2 - Adventure Mall Surprize! | 2011 | nds |
| Squirrel ~ O Esquilo | 1983 | a2600 |
| Squish and the Corrupted Crystal | 2017 | xboxone |
| Stallar | 2022 | nes |
| Standpoint | 2015 | xboxone |
| Star Trek V - The Final Frontier | 1989 | nes |
| Star Wars | 1991 | gb, gg, sms |
| Star Wars | 1993 | genesis |
| Star Wars | 1987 | nes |
| Star Wars - Episode II - Attack of the Clones | 2002 | gba |
| Star Wars - The Empire Strikes Back | 1992 | gb, nes |
| Star Wars Trilogy - Apprentice of the Force | 2004 | gba |
| Starshot - Space Circus Fever | 1998 | n64 |
| Startled 911 | 2001 | gbc |
| Station 1 | 1998 | ps1 |
| Station 4 | 1999 | ps1 |
| Steal Princess | 2008 | nds |
| SteamWorld Dig 2 | 2017 | ps4, switch, vita, xboxone |
| Steamworld Dig | 2013 | 3ds, ps4, switch, vita, wiiu, xboxone |
| Stela | 2019 | switch, xboxone |
| Stick It to the Man! | 2013 | ps3, ps4, vita, wiiu, xboxone |
| Stick Man Guy | 2024 | gb |
| Sticktype | 2018 | xboxone |
| Stranded - A Mars Adventure | 2016 | vita |
| Strawberry Shortcake - The Four Seasons Cake | 2007 | nds |
| Streemerz | 2012 | nes |
| Street Fighter 2010 - The Final Fight | 1990 | nes, wiiu |
| Strider | 2022 | arcade |
| Strider 2 | 1999 | arcade |
| Strider Hiryu | 1989 | arcade, nes |
| Strider Hiryu 2 | 1999 | arcade |
| Strider Hiryuu | 1994 | pcengine |
| Strider II | 1992 | genesis, sms |
| Struggling | 2020 | switch |
| Stuart Little - The Journey Home | 2001 | gbc |
| Stuart Little 2 | 2002 | gba, ps1 |
| Stuart Little 3 - Big Photo Adventure | 2005 | ps2 |
| Stunt Man | 1983 | a2600 |
| The Suite Life of Zack & Cody - Tipton Trouble | 2006 | nds |
| Sumo Fighter | 1993 | gb |
| Sumou Fighter - Toukaidou Basho | 1991 | gb |
| Sun Xiaomao Qihuan Dao - Kiddy Sun in Fantasia | 1987 | nes |
| Sunman | 1992 | nes |
| Super Adventure Island II | 2011 | wii |
| Super Aladdin | 1994 | nes |
| Super Aladdin - The Return of Jafar | 1996 | nes |
| Super Arabian | 1985 | nes |
| Super Athena | 1987 | arcade |
| Super B.C. Kid | 1995 | snes |
| Super Bagman | 1984 | arcade |
| Super Bikkuriman - Densetsu no Sekiban | 1992 | gb |
| Super Bioman I | 1992 | sms |
| Super Blast Deluxe | 2016 | vita |
| Super Bobble Bobble | 1986 | arcade |
| Super Bonk | 1994 | snes |
| Super Boy I | 1989 | sms |
| Super Bros. 2 | 1988 | nes |
| Super Bros. 5 | 1988 | nes |
| Super Bros. 6 | 2005 | nes |
| Super Bros. 8 | 2021 | nes |
| Super Bros. 9 | 1992 | nes |
| Super Bubble 2003 | 2003 | arcade |
| Super Bubble Bobble | | genesis |
| Super Bubble Bobble | 1996 | arcade |
| Super Bubble Bobble | 1986 | arcade |
| Super Burger Time | 1990 | arcade |
| Super Chariot | 2018 | switch |
| Super Cloudbuilt | 2017 | ps4, xboxone |
| Super Contra 6 | 1992 | nes |
| Super Contra 8 | 1999 | nes |
| Super Contra II | 1993 | nes |
| Super Crusher Fighters | | nes |
| Super DK! | 1982 | col |
| Super Dassalo Land | 2024 | gbc |
| Super Don Quix-ote | 1984 | arcade |
| Super Donkey | 1994 | snes |
| Super Donkey Kong | 1997 | nes |
| Super Donkey Kong | 1994 | snes |
| Super Donkey Kong | 2014 | wii |
| Super Donkey Kong | 2014 | wiiu |
| Super Donkey Kong - Xiang Jiao Chuan | 1998 | nes |
| Super Donkey Kong 2 | 1997 | nes |
| Super Donkey Kong 2 - Dixie & Diddy | 1995 | snes |
| Super Donkey Kong 2 - Dixie & Diddy | 2014 | wii |
| Super Donkey Kong 2 - Dixie & Diddy | 2014 | wiiu |
| Super Donkey Kong 3 - Nazo no Kremis-tou | 1996 | snes |
| Super Donkey Kong 99 | 1999 | genesis |
| Super Donkey Kong GB | 1995 | gb |
| Super Farm | 2003 | ps2 |
| Super Genjin | 1994 | snes |
| Super Genjin | 2014 | wii |
| Super Ghouls 'N Ghosts | 1991 | gba, snes, wiiu |
| Super Glob | 1983 | arcade |
| Super Hard Bouncer | 2024 | gb, genesis, nes |
| Super Hero | 1998 | nes |
| Super Hunchback | 1992 | gb |