| Yoshi's Crafted World | 2019 | switch |
| Yoshi's Island DS | 2006 | nds |
| Yoshi's Island DS | 2015 | wiiu |
| Yoshi's New Island | 2014 | 3ds |
| Yoshi's Story | 1997 | n64, wiiu |
| Yoshi's Story | 2007 | wii |
| Yoshi's Universal Gravitation | 2004 | gba |
| Yoshi's Woolly World | 2015 | 3ds, wiiu |
| You Are Insignificant | 2016 | nes |
| Youkai Buster - Ruka no Daibouken | 1995 | snes |
| Youkai Club | 1987 | nes |
| Youkai Douchuuki | 1988 | nes |
| Youkai Douchuuki | 1988 | pcengine |
| Youkai Yashiki | 1987 | fds |
| The Young Indiana Jones Chronicles | 1994 | genesis |
| The Young Indiana Jones Chronicles | 1992 | nes |
| Yousei Monogatari - Rod Land | 1992 | gb, nes |
| Yuanshi Mali VII | 1991 | nes |
| Yume Koujou - Doki Doki Panic | 1987 | fds |
| Yume Penguin Monogatari | 1991 | nes |
| Yun | 2016 | nes |
| Yurivania 0 - Soul Night Prelude | 2021 | gbc |
| The Z Axis: Continuum | 2018 | xboxone |
| Zack Zero | 2012 | ps3 |
| Zdey The Game | 2021 | nes |
| Zen - Intergalactic Ninja | 1993 | gb, nes |
| Zero Zero Zero Zero | 2020 | vita |
| Zhen Jia Hou Wang | 1996 | nes |
| Zhong Zhuang Ji Bing | 1990 | nes |
| Zhu Zhu Pets - Quest for Zhu | 2004 | nds |
| Zhuo Hou La - Baiwan Houjun Jingbao Da Chuji | 2006 | ps2 |
| Zillion II - The Tri Formation | 1987 | sms |
| Zippy The Pinecone | 2024 | gbc |
| Zoboomafoo - Playtime in Zobooland | 2001 | gbc |
| Zombie Calavera Prologue | 2010 | nes |
| Zombie High | 1994 | genesis |
| Zombie Incident | 2015 | 3ds |
| Zombies | 2009 | wii |
| Zombies Ate My Neighbors | 2009 | wii |
| Zoo Fun | 1983 | a2600 |
| Zook Man ZX4 | 2016 | gba |
| Zook Z | 1998 | gbc |
| Zool | 1993 | gb, genesis, snes |
| Zool - Ninja of the 'Nth' Dimension | 1993 | cd32, gb, gg |
| Zool - Ninja of the 'Nth' Dimension | 1993 | genesis, sms, snes |
| Zool 2 | 1994 | cd32, jaguar |
| Zool Redimensioned | 1994 | genesis |
| Zool no Yume Bouken | 1994 | gg |
| Zooming Secretary - Going Panic | 2018 | genesis |
| Zou! Zou! Zou! Rescue Daisakusen | 1993 | genesis |
| Zupapa! | 2001 | arcade, neogeo |
| Zwackery | 1984 | arcade |
| de Blob 2 | 2011 | nds, ps3, wii, xbox360 |
| iO | 2017 | ps4, vita, xboxone |
| xXx | 2002 | gba |