| Uchuu no Kishi Tekkaman Blade | 1992 | gb |
| Ultimate Chicken Horse | 2017 | ps4, switch, xboxone |
| Ultimate Ghosts'n Goblins | 2006 | psp |
| Ultimate NES Remix | 2014 | 3ds |
| Ultra Balloon | 1996 | arcade |
| Ultraman - Kaijuu Teikoku no Gyakushuu | 1987 | fds |
| Ultraman Ball | 1994 | gb |
| Ultratron | 2015 | xboxone |
| Umihara Kawase Fresh! | 2019 | ps4, switch |
| Umihara Kawase Portable | 2008 | psp |
| Umihara Kawase Shun | 1997 | ps1 |
| Umihara Kawase Shun - Second Edition | 2000 | ps1 |
| Umihara Kawase Shun - Second Edition Kanzen Ban | 2009 | nds |
| Unbound: Worlds Apart | 2021 | switch |
| Unbox: Newbie's Adventure | 2017 | ps4, xboxone |
| Underground Adventure | 2019 | nes |
| Underhero | 2020 | ps4, xboxone |
| Unepic | 2014 | ps4, switch, vita, wiiu, xboxone |
| Unit 4 | 2017 | xboxone |
| Universal Soldier | 1992 | gb, genesis, snes |
| Unmechanical: Extended | 2015 | ps4, xboxone |
| Unravel | 2016 | ps4, xboxone |
| Unravel Two | 2018 | ps4, switch, xboxone |
| Up Maguila | 1982 | arcade |
| Urban Trial Freestyle | 2013 | 3ds, ps3, vita |
| Urusei Yatsura - Lum no Wedding Bell | 1986 | nes |
| Ushio to Tora | 1993 | snes |
| Utsurun Desu. - Kawauso Hawaii e Iku | 1992 | nes |
| VS. Castlevania | 1987 | arcade |
| VS. Gumshoe | 1986 | arcade |
| VS. Ice Climber | 1984 | arcade |
| VS. Mighty Bomb Jack | 1986 | arcade |
| VS. Ninja Jajamaru-kun | 1985 | arcade |
| VS. Super Mario Bros | 1986 | arcade |
| VVVVVV | 2011 | 3ds, ps4, switch, vita |
| Valfaris | 2019 | ps4, switch, xboxone |
| Valis | 2022 | genesis |
| Valley | 2019 | switch |
| Vampire | | sms |
| Vampire - Master of Darkness | 1993 | gg |
| Vampire Killer | 1994 | genesis |
| Vecinos Invasores | 2006 | nds |
| Venom & Spider-Man - Separation Anxiety | 1997 | arcade |
| Vertical Drop Heroes HD | 2017 | vita |
| Vib-Ribbon | 1999 | ps1 |
| Vicky the Viking - Part 2 | 2011 | nds |
| Video Vince and the Game Factory | 1984 | arcade |
| Viewtiful Joe Revival | 2003 | gc |
| Vigil: The Longest Night | | ps4 |
| Vigilante | 1988 | arcade |
| Viking no Daimeiwaku | 1993 | snes |
| Virtual Bart | 1994 | genesis, snes |
| Virtual Boy Wario Land | 1995 | vb |
| Virtual Wars | 1994 | gb, snes |
| Virtuous Western | 2021 | ps4 |
| Volgarr the Viking | 2014 | dreamcast, xboxone |
| Volgarr the Viking | 2016 | ps4, switch, vita, wiiu |
| Volgarr the Viking II | 2024 | ps4, xboxone |
| Voodoo Vince | 2003 | xbox, xboxone |
| Voyage - A Sorceress' Vacation | 2020 | sms |
| Vs. Balloon Fight | 1984 | arcade |
| Vs. Ice Climber Dual | 1984 | arcade |
| Vs. Skate Kids | 1988 | arcade |
| Vs. The Goonies | 1986 | arcade |
| Vs. Wrecking Crew | 1984 | arcade |
| W.i.t.c.h | 2005 | gba |
| WALL-E | 2008 | nds, ps3, psp |
| Wacky Races | 1992 | nes |
| Wagyan Land | 1991 | gg |
| Wagyan Land | 1989 | nes, wiiu |
| Wagyan Land 2 | 1990 | nes |
| Wagyan Land 3 | 1992 | nes |
| Wai Wai World 2 - SOS!! Parsley Jou | 1991 | nes |
| Wai Xing Tanxian Zhi Xingqiu Dazhan | | gbc |
| Wait and See! | 1997 | nes |
| Walk in the Dark | 2017 | xboxone |
| Walker ~ Schussel, der Polizistenschreck | 1983 | a2600 |
| Wall Jump Ninja | 2015 | a2600 |
| Wallace & Gromit - The Curse of the Were-Rabbit | 2005 | ps2, xbox |
| Wallace to Gromit - Yasaibatake de Dai-Pinch! | 2005 | ps2 |
| Wally Bear and the No! Gang | 1990 | nes |
| Wanpaku Duck Yume Bouken | 1990 | nes |
| Wanpaku Kokkun no Gourmet World | 1992 | nes |
| The War of the Worlds | 2011 | xbox360 |
| Wardner | 1987 | arcade, fds, genesis |
| Wario - Master of Disguise | 2007 | nds |
| Wario - Master of Disguise | 2016 | wiiu |
| Wario Land - Shake It! | 2008 | wii |
| Wario Land - Super Mario Land 3 | 1994 | gb |
| Wario Land - The Shake Dimension | 2008 | wii |
| Wario Land 3 | 2000 | gbc |
| Wario Land 4 | 2001 | gba |
| Wario Land II | 1998 | gb, gbc |
| Wario Land Shake | 2008 | wii |
| Wario Land Shaking | 2011 | wii |
| Wario World | 2003 | gc |
| Wart Worm Wingding! | 2019 | nes |
| Waterworld | 1996 | genesis |
| The Way | 2017 | xboxone |
| The Way Remastered | 2018 | switch |