| Ropeman | 1983 | arcade |
| Rottatouille | 2007 | psp |
| Routes to Reading | 1995 | cdi |
| Rubble Saver | 1991 | gb |
| Rubble Saver II | 1992 | gb |
| Ruby & Rusty Save the Crows | 2020 | gbc |
| Rue The Rosey Buddy 3 | 2026 | genesis |
| Ruff & Tumble | 1999 | ps1 |
| Rugrats - Castle Capers | 2001 | gba |
| Rugrats - Go Wild | 2003 | gba |
| Rugrats - I Gotta Go Party | 2002 | gba |
| The Rugrats Movie | 1998 | gb, gbc |
| Rugrats en Paris - La pelicula | 2000 | gbc |
| Rugrats in Paris - The Movie | 2001 | gbc |
| Rugrats in Paris - The Movie | 2000 | n64 |
| Rugrats: Adventures in Gameland | 2024 | switch |
| Run Run and Die | 2016 | wiiu |
| Runbow | 2015 | ps4, switch, wiiu, xboxone |
| Runbow Pocket Deluxe Edition | 2017 | 3ds |
| Runner2: Future Legend of Rhythm Alien | 2016 | ps4 |
| Runner3 | 2018 | ps4, switch |
| Ruruli Ra Rura | 1998 | pcfx |
| Rush'n Attack | 2007 | xbox360 |
| Rush'n Attack - Ex-Patriot | 2011 | ps3, xbox360 |
| Rygar | 1990 | lynx |
| Rygar | 1986 | arcade, nes |
| S.O.S | | arcade |
| Saban's Power Rangers - Lightspeed Rescue | 2000 | gbc |
| Saban's Power Rangers - Time Force | 2001 | gbc |
| Saboten Bombers | 1992 | arcade |
| Sabre Wulf | 2004 | gba |
| Sabrina - The Animated Series - Spooked! | 2001 | gbc |
| Sabrina - The Animated Series - Zapped! | 2000 | gbc |
| Sabrina l'Apprentie Sorciere et l'Horloge Cosmique | 2001 | ps1 |
| Sabrina the Teenage Witch - A Twitch in Time! | 2001 | ps1 |
| Sabrina the Teenage Witch - Potion Commotion | 2002 | gba |
| Sack of Flour - Heart of Gold | 2002 | nes |
| Sackboy's Prehistoric Moves | 2010 | ps3 |
| Sackboy: A Big Adventure | 2020 | ps4 |
| Sai Yu Gou Ma Roku | 1988 | arcade |
| Saigo no Nindou - Ninja Spirit | 1990 | pcengine |
| Saigo no Nindou - Ninja Spirit | | wii |
| Sailor Moon - La Luna Splende | 2004 | nds |
| Saiyuuki Kinkaku Ginkaku no Inbou | 2007 | nds |
| Saiyuuki World 2 - Tenjoukai no Majin | 1990 | nes |
| Sally's Law | 2018 | switch, xboxone |
| Sam the Optimistic Hedgehog | 2023 | gbc |
| Samurai Jack - The Amulet of Time | 2003 | gba |
| Samurai-Ghost | 1992 | pcengine |
| Santa Claus Jr. Advance | 2002 | gba |
| Santa Claus Saves the Earth | 2002 | gba, ps1 |
| The Santa Clause 3 - The Escape Clause | 2006 | gba |
| Sapo Xule vs. Os Invasores do Brejo | 1995 | sms |
| Sarmly Bot | 2025 | nes |
| Saru Get You - SaruSaru Daisakusen | 2007 | psp |
| Saru! Get You! 3 | 2005 | ps2 |
| Saru! Get You! 3 | 2014 | ps3 |
| Saru! Get You! Million Monkeys | 2006 | ps2 |
| Sassou Shounen Eiyuuden - Coca-Cola Kid | 1994 | gg |
| Satan Claus | 2024 | genesis |
| Saturn Smash | 2019 | nes |
| A Satyr in Hell | 2022 | genesis |
| Save the Ninja Clan | 2017 | vita, xboxone |
| Scaler | 2004 | gc, ps2, xbox |
| Scarygirl | 2012 | ps3, xbox360 |
| Schim | 2024 | xboxone |
| Scooby-Doo 2 - Monsters Unleashed | 2004 | gba |
| Scooby-Doo Mystery | 1995 | genesis, snes |
| Scooby-Doo! - Unmasked | 2005 | gba, gc, nds, ps2, xbox |
| Scooby-Doo! Night of 100 Frights | 2002 | gc, ps2, xbox |
| The Scorpion King - Sword of Osiris | 2002 | gba |
| Scram Kitty DX | 2015 | ps4, vita |
| Scram Kitty and his Buddy on Rails | 2014 | wiiu |
| Scrapyard Dog | 1990 | a7800, lynx |
| Screw Breaker - Goushin DoriRureRo | 2015 | wiiu |
| Scribblenauts | 2009 | nds |
| Sea Hunter Penguin | 1995 | arcade |
| Seasaw Space Security Squad | 2024 | genesis |
| Seasons After Fall | 2017 | ps4, xboxone |
| Secret Agent Barbie - Royal Jewels Mission | 2002 | gba |
| Secret Agent Clank | 2008 | ps2, psp |
| Sega Classics Arcade Collection | 1992 | segacd |
| SegaSonic The Hedgehog | 1992 | arcade |
| Segapede | 1994 | genesis |
| Seikima II - Akuma no Gyakushuu! | 1986 | nes |
| Seirei Densetsu Lickle | 1992 | nes |
| Semblance | 2018 | switch |
| Seoul Symphony | 1994 | arcade |
| Sephonie | 2023 | ps4, switch, xboxone |
| Sergio Kidd | 2025 | gbc |
| Sesame Street - The Adventures of Elmo in Grouchland | 1999 | gbc |
| Seum: Speedrunners from Hell | 2017 | ps4, xboxone |
| The Seven Gates of Jambala | 1994 | cd32 |
| Shadow Dancer | 1990 | genesis |
| Shadow Dancer | | wii |
| Shadow Dancer | 1989 | arcade |
| Shadow Dancer - The Secret of Shinobi | 1990 | genesis, sms |
| Shadow Dancer - The Secret of Shinobi | 2010 | wii |
| Shadow Labyrinth | 2025 | switch |
| Shadow Warriors | 1992 | gb |