| Route-16 Turbo | JP | 1985-10-04 |
Sunsoft | Commercial |
| Royal Blood | JP | 1991-08-29 |
Koei | Commercial |
| Rumble Station - 15 in 1 | US | |
Pelican Accessories | Unlicensed |
| Rumblefest '89 | WORLD | 2020-09 |
Jurassic Sunset Games | Prototype |
| Run Dash Run | WORLD | |
| Prototype |
| Rush'n Attack | AS | 1987-04 |
| Unlicensed |
| Rush'n Attack | EU | 1989-06-28 |
Konami | Commercial |
| Rush'n Attack | RU | 1989-06-28 |
| Unlicensed |
| Rush'n Attack | US | 1987-04 |
Konami | Commercial |
| Russian Roulette | WORLD | 2016-10 |
Romhacking.net | Unlicensed |
| Russian Roulette | WORLD | 2016-10 |
Romhacking.net | Prototype |
| Rygar | EU | 1990-03-30 |
Tecmo | Commercial |
| Rygar | US | 1987-07 |
Tecmo | Commercial |
| Rygar | US | 1987-07 |
Tecmo | Demo |
| S. M. Bros. 1988 | US | |
| Unlicensed |
| S.C.A.T. - Special Cybernetic Attack Team | EU | 1992 |
Infogrames | Commercial |
| S.C.A.T. - Special Cybernetic Attack Team | US | 1991-06 |
Infogrames | Commercial |
| S.C.A.T. - Special Cybernetic Attack Team | US | 1991-06 |
Infogrames | Prototype |
| S.T.I.N.G | WORLD | 2008 |
| Unlicensed |
| SD Battle Oozumou - Heisei Hero Basho | JP | 1990-04 |
Banpresto | Commercial |
| SD Gaoda Waizhuan - Qishi Gaoda Gushi 3 - Chuanshuo Zhi Qishi Tuan | CN | |
| Unlicensed |
| SD Gundam - Gachapon Senshi 2 - Capsule Senki | JP | 1989-06 |
Bandai | Commercial |
| SD Gundam - Gachapon Senshi 3 - Eiyuu Senki | JP | 1990-12 |
Yutaka | Commercial |
| SD Gundam - Gachapon Senshi 4 - NewType Story | JP | 1991-12 |
Yutaka | Commercial |
| SD Gundam - Gachapon Senshi 5 - Battle of Universal Century | JP | 1992-12 |
Yutaka | Commercial |
| SD Gundam - Gundam Wars | JP | 1993-04 |
Bandai Namco | Commercial |
| SD Gundam Gaiden - Knight Gundam Monogatari | JP | 1990-08-11 |
Bandai | Commercial |
| SD Gundam Gaiden - Knight Gundam Monogatari 2 - Hikari no Knight | JP | 1991-10 |
Bandai | Commercial |
| SD Gundam Gaiden - Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | JP | 1992-10-23 |
Bandai Namco | Commercial |
| SD Hero Soukessen - Taose! Aku no Gundan | JP | 1990-07 |
Banpresto | Commercial |
| SD Keiji - Blader | JP | 1991-08-02 |
Taito | Commercial |
| SD Sengoku Bushou Retsuden | JP | 1990-09 |
Banpresto | Commercial |
| SMMM | WORLD | |
| Unlicensed |
| STED - Iseki Wakusei no Yabou | JP | 1990-07 |
K. Amusement Leasing Co | Commercial |
| SWAT - Special Weapons and Tactics | JP | 1987-09-11 |
Toei Animation | Commercial |
| Saboteur | US | |
| Unlicensed |
| Sack of Flour - Heart of Gold | WORLD | 2002-05 |
| Unlicensed |
| Saint Seiya - Ougon Densetsu | JP | 1987-08 |
Bandai | Commercial |
| Saint Seiya - Ougon Densetsu Kanketsu Hen | JP | 1988-05 |
Bandai Namco | Commercial |
| Saint Seiya - Ougon Densetsu Kanketsu Hen | JP | 1988-05 |
Bandai Namco | Prototype |
| Saiwai Qixia Zhuan | CN | |
| Unlicensed |
| Saiya Ren Miejue Jihua | CN | |
| Unlicensed |
| Saiyuuki World | JP | 1988-11 |
Jaleco | Commercial |
| Saiyuuki World | JP | 1988-11 |
Jaleco | Prototype |
| Saiyuuki World 2 - Tenjoukai no Majin | JP | 1990-12 |
Jaleco | Commercial |
| Sakigake!! Otoko Juku - Shippuu Ichi Gou Sei | JP | 1989-03 |
Bandai | Commercial |
| Salad no Kuni no Tomato Hime | JP | 1988-07 |
Hudson Soft | Commercial |
| Salamander | JP | 1987-09-25 |
Konami | Commercial |
| Samsara Naga | JP | 1990-03 |
Victor Interactive Software | Commercial |
| Samurai Shodown III | TW | 1997 |
| Unlicensed |
| Samurai Zombie Nation | AS | |
| Unlicensed |
| San Guo Zhi - Qun Xiong Zheng Ba | TW | |
Asder | Unlicensed |
| Sanada Juu Yuushi | JP | 1988-06 |
Kemco | Commercial |
| Sand Emperor | WORLD | 2021-02 |
Ti_ | Demo |
| Sangoku III | AS | |
| Unlicensed |
| Sangokushi | JP | 1988-08 |
Koei | Commercial |
| Sangokushi - Chuugen no Hasha | JP | 1988-10 |
Namco | Commercial |
| Sangokushi II | JP | 1990-11-02 |
Koei | Commercial |
| Sangokushi II - Haou no Tairiku | CN | 1992-06-10 |
| Unlicensed |
| Sangokushi II - Haou no Tairiku | JP | 1990-11 |
Koei | Commercial |
| Sangokushi III - Haou no Tairiku | AS | |
| Unlicensed |
| Sanguo Chunqiu - Sichuan Sheng | AS | 1996 |
| Unlicensed |
| Sanguo Daluan Dou - Zhanguo | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Sanguo Fengyun | CN | |
| Unlicensed |
| Sanguo Qun Xia Zhuan | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Sanguo Qunying Chuan | CN | |
| Unlicensed |
| Sanguo Taoyuan Ji - The Story of Three Kingdoms | CN | |
| Unlicensed |
| Sanguo Wushuang - Mengjiang Zhuan | CN | |
| Unlicensed |
| Sanguo Zhonglie Zhuan - The Story of Three Kingdoms | CN | |
| Unlicensed |
| Sanguozhi - Caocao Zhuan | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Sanguozhi - Chibi Zhi Zhan | TW | 1993-06 |
NTDEC | Unlicensed |
| Sanguozhi - Lubu Zhuan | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Sanguozhi - Shu Wei Zhengba | CN | |
| Unlicensed |
| Sanguozhi - Shuhan Fengyun | CN | |
| Unlicensed |
| Sanguozhi - Xiongba Tianxia | CN | |
| Unlicensed |
| Sanguozhi - Yingjie Zhuan | CN | |
| Unlicensed |
| Sanguozhi - Yingjie Zhuan - Hero Legend | CN | |
| Unlicensed |
| Sanguozhi - Zhi Aoshi Tiandi | CN | |
| Unlicensed |
| Sanguozhi - Zhi Qian Jun Po | CN | |
| Unlicensed |
| Sanguozhi 2 - Zhongwen Jiaqiang Ban | CN | |
| Unlicensed |
| Sanguozhi II | CN | |
| Unlicensed |
| Sanguozhi II Dai | CN | |
| Unlicensed |
| Sanguozhi III | CN | |
| Unlicensed |
| Sanguozhi IV - Chibi Fengyun | TW | |
| Unlicensed |
| Sanma no Meitantei | JP | 1987-04-02 |
Namco | Commercial |
| Sanrio Carnival | JP | 1990-11-22 |
Character Soft | Commercial |
| Sanrio Carnival 2 | JP | 1993-01-14 |
Character Soft | Commercial |
| Sanrio Cup - Pon Pon Volley | JP | 1992-07-17 |
Character Soft | Commercial |
| Sanshiliu Ji - The Thirty-Six Tricks | CN | |
| Unlicensed |
| Sansuu 1 Nen - Keisan Game | JP | 1986-04 |
Tokyo Shoseki | Commercial |
| Sansuu 2 Nen - Keisan Game | JP | 1986-04 |
Tokyo Shoseki | Commercial |
| Sansuu 3 Nen - Keisan Game | JP | 1986-04 |
Tokyo Shoseki | Commercial |
| Sansuu 4 Nen - Keisan Game | JP | 1986-10 |
Tokyo Shoseki | Commercial |
| Sansuu 4 Nen - Keisan Game | JP | 1986-10 |
Tokyo Shoseki | Prototype |
| Sansuu 5 & 6 Nen - Keisan Game | JP | 1986-10 |
Tokyo Shoseki | Commercial |
| Sansuu 5 & 6 Nen - Keisan Game | JP | 1986-10 |
Tokyo Shoseki | Prototype |
| Santa's Snowman | WORLD | 2022-12 |
Toad64 | Unlicensed |
| Sanxia Wuyi - Yumao Chuanqi | CN | |
| Unlicensed |
| Sarmly Bot | WORLD | 2025-01 |
James Tall | Unlicensed |
| Sarmly Bot in Castle | WORLD | |
| Unlicensed |