| Stadium Events | US | 1987-09 |
Bandai | Commercial |
| Stakk'm | US | 1991 |
American Video Entertainment | Prototype |
| Stallar | WORLD | 2022-04 |
Wendel Scardua | Demo |
| Stanley - The Search for Dr. Livingston | US | 1992-10 |
Electro Brain | Commercial |
| Stanley - The Search for Dr. Livingston | US | 1992-10 |
Electro Brain | Prototype |
| Stanley - The Search for Dr. Livingston | WORLD | 1992-10 |
Electro Brain | Commercial |
| Star Dust | JP | |
| Unlicensed |
| Star Evil | WORLD | |
| Unlicensed |
| Star Force | EU | 1985-06-25 |
Tecmo | Commercial |
| Star Force | JP | 1985-06-25 |
Tecmo | Commercial |
| Star Force | TW | 1985-06-25 |
| Unlicensed |
| Star Force | US | 1987-11 |
Tecmo | Commercial |
| Star Force | US | 1987-11 |
Tecmo | Prototype |
| Star Gate | JP | 1987-09-24 |
HAL Laboratory | Commercial |
| Star Luster | JP | 1985-12-06 |
Namco | Commercial |
| Star Luster | WORLD | 1985-12-06 |
Namcot | Commercial |
| Star Retrievers | WORLD | |
| Demo |
| Star Ship Go!! | JP | |
| Unlicensed |
| Star Soldier | JP | 1986-06-13 |
Konami | Commercial |
| Star Soldier | JP | 1986-06-13 |
Konami | Demo |
| Star Soldier | US | 1989-01 |
Konami | Commercial |
| Star Trek - 25th Anniversary | DE | 1992-02 |
Ultra Games | Commercial |
| Star Trek - 25th Anniversary | US | 1992-02 |
Ultra Games | Commercial |
| Star Trek - The Next Generation | US | 1993-09 |
Absolute Entertainment | Commercial |
| Star Trek V - The Final Frontier | US | 1989 |
Bandai Namco | Prototype |
| Star Versus | EU | 2015-03 |
Studio Dustmop | Unlicensed |
| Star Versus | US | 2015-03 |
Studio Dustmop | Unlicensed |
| Star Versus | WORLD | 2015-03 |
Studio Dustmop | Unlicensed |
| Star Voyager | US | 1987-09 |
Acclaim Entertainment | Commercial |
| Star Wars | EU | 1987-12-04 |
JVC | Commercial |
| Star Wars | JP | 1991-11 |
JVC | Commercial |
| Star Wars | US | 1991-12 |
JVC | Commercial |
| Star Wars | US | 1991-12 |
JVC | Prototype |
| Star Wars - The Empire Strikes Back | EU | 1992-03 |
JVC Musical Industries | Commercial |
| Star Wars - The Empire Strikes Back | JP | 1993-03-12 |
JVC Musical Industries | Commercial |
| Star Wars - The Empire Strikes Back | US | 1992-03 |
JVC Musical Industries | Commercial |
| Star Wars - The Empire Strikes Back | US | 1992-03 |
JVC Musical Industries | Prototype |
| StarTropics | EU | 1992-08-20 |
Nintendo | Commercial |
| StarTropics | US | 1990-12-26 |
Nintendo | Commercial |
| Starfight | WORLD | |
| Unlicensed |
| Starship Hector | US | 1990-06 |
Hudson Soft | Commercial |
| Starship Shooters | WORLD | |
| Demo |
| Stealth ATF | BR | 1989-10 |
Activision | Unlicensed |
| Stealth ATF | EU | 1991-11-14 |
Activision | Commercial |
| Stealth ATF | US | 1989-10 |
Activision | Commercial |
| Steel Moons | WORLD | 2023-07 |
Mazionach | Unlicensed |
| Stellarator | WORLD | |
| Demo |
| Stereo Baseball | AS | |
| Unlicensed |
| Stick Hunter - Exciting Ice Hockey | JP | 1987-12-18 |
K. Amusement Leasing Co | Commercial |
| Stinger | US | 1987-09 |
Konami | Commercial |
| Strategist | AS | 1991 |
Sachen | Unlicensed |
| Strategist | TW | 1991 |
Sachen | Unlicensed |
| Stray Dog Strut | WORLD | |
| Unlicensed |
| Streemerz | WORLD | 2012 |
Faux Game | Unlicensed |
| Street Blaster IV - Pro 10 | AS | 1993 |
| Unlicensed |
| Street Blaster V - Turbo 20 | AS | 1993 |
| Unlicensed |
| Street Cop | US | 1989-06 |
Bandai Namco | Commercial |
| Street Dance | CN | 2000 |
Invent | Unlicensed |
| Street Fighter - 60 Players | AS | |
| Unlicensed |
| Street Fighter 2010 - The Final Fight | US | 1990-09 |
Capcom | Commercial |
| Street Fighter 2010 - The Final Fight | US | 1990-09 |
Capcom | Prototype |
| Street Fighter 6 | AS | |
| Unlicensed |
| Street Fighter II | TW | 1992 |
| Unlicensed |
| Street Fighter II Pro | AS | 1993 |
| Unlicensed |
| Street Fighter III | AS | 1997-12 |
| Unlicensed |
| Street Fighter V | AS | |
| Unlicensed |
| Street Fighter V - Turbo 60 | TW | 1996 |
| Unlicensed |
| Street Fighter VI | AS | 1996 |
| Unlicensed |
| Street Fighter X - Turbo 40 | TW | 1993 |
| Unlicensed |
| Street Fighter Zero 2 | TW | |
| Unlicensed |
| Street Fighter Zero 2 '97 | TW | 1997 |
| Unlicensed |
| Street Gangs | EU | 1991 |
Infogrames | Commercial |
| Street Hero | US | |
| Prototype |
| Street Heroes | AS | 1994 |
Sachen | Unlicensed |
| Strider | US | 1989-07 |
Capcom | Commercial |
| Strider Hiryu | JP | 1988 |
Capcom | Prototype |
| Strike Wolf | AS | 1992 |
Micro Genius | Unlicensed |
| Stunt Buggies | WORLD | 1992 |
Camerica | Unlicensed |
| Stunt Kids | US | 1992 |
Camerica | Unlicensed |
| Subor | CN | |
Subor | Unlicensed |
| Subor - Learning Computer | RU | |
| Unlicensed |
| SuborWin 2000 | RU | 2002 |
| Unlicensed |
| Substation 7 | WORLD | |
| Demo |
| Sudo King | AS | |
| Unlicensed |
| Sudoku | WORLD | 2007 |
NESWorld | Unlicensed |
| Sudoku 2007 | EU | 2007 |
Retrozone | Unlicensed |
| Sudoku 2007 | US | 2007 |
Retrozone | Unlicensed |
| Sudoku 23 | WORLD | 2023-03 |
Johnybot | Unlicensed |
| Sugoro Quest - Dice no Senshitachi | AS | 1991-06 |
| Unlicensed |
| Sugoro Quest - Dice no Senshitachi | JP | 1991-06 |
Technōs Japan | Commercial |
| Suikoden - Tenmei no Chikai | JP | 1990-06-25 |
Koei | Commercial |
| Suitang Yanyi | CN | |
| Unlicensed |
| Suitang Yingxiong | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Sukeban Deka III | JP | 1988-01-22 |
Toei Animation | Commercial |
| Summer Carnival '92 - Recca | JP | 1992-07-17 |
Naxat Soft | Commercial |
| Summer Games Done Quick 2019 Event Schedule | WORLD | |
| Unlicensed |
| Summer Island Battle Tactics | WORLD | |
| Demo |
| Sun Xiaomao Qihuan Dao - Kiddy Sun in Fantasia | TW | 1987 |
Hudson Soft | Commercial |
| Sunday Funday - The Ride | US | 1995 |
Wisdom Tree | Unlicensed |
| Sunman | EU | 1992 |
Sunsoft | Prototype |