| Soccer | EU | 1987-01-15 |
Nintendo | Commercial |
| Soccer | JP | 1985-04-09 |
Nintendo | Commercial |
| Soccer | US | 1985-10-18 |
Nintendo | Commercial |
| Soccer League - Winner's Cup | JP | 1988-08 |
Data East | Commercial |
| Softball Tengoku | JP | 1989-10-27 |
Brøderbund Software | Commercial |
| Soko Banana | WORLD | 2024-12 |
Flip For Fate | Demo |
| Soko Banana | WORLD | 2024-12 |
Flip For Fate | Unlicensed |
| Soko Banana - Tinsel Island | WORLD | 2024-12 |
Flip For Fate | Unlicensed |
| Sokoban | WORLD | |
| Prototype |
| Solar Jetman - Hunt for the Golden Warpship | EU | 1991-09-26 |
Nintendo | Commercial |
| Solar Jetman - Hunt for the Golden Warpship | US | 1990-09 |
Nintendo | Commercial |
| Solar Wars | WORLD | 2001-04 |
CMC Games | Unlicensed |
| Solar Wars | WORLD | 2001-04 |
CMC Games | Prototype |
| Solaris | US | 2016 |
retroUSB | Unlicensed |
| Solitaire | US | 1992 |
American Video Entertainment | Unlicensed |
| Solomon no Kagi | JP | 1986-07 |
Tecmo | Commercial |
| Solomon no Kagi 2 - Coolmintou Kyuushutsu Sakusen | JP | 1992-01 |
Tecmo | Commercial |
| Solomon's Key | EU | 1990-03-30 |
Tecmo | Commercial |
| Solomon's Key | US | 1987-07 |
Tecmo | Commercial |
| Solomon's Key | US | 1987-07 |
Tecmo | Prototype |
| Solomon's Key 2 | EU | 1993-03-18 |
Tecmo | Commercial |
| Solomon's Key 2 | US | 1993-03 |
Tecmo | Prototype |
| Solstice - Sanjigen Meikyuu no Kyoujuu | JP | 1990-07 |
Nintendo | Commercial |
| Solstice - The Quest for the Staff of Demnos | EU | 1991-09-26 |
Nintendo | Commercial |
| Solstice - The Quest for the Staff of Demnos | US | 1990-06 |
Nintendo | Commercial |
| Solstice - The Quest for the Staff of Demnos | US | 1990-06 |
Nintendo | Prototype |
| Somari | AS | 1994 |
| Unlicensed |
| Somari | TW | 1994 |
Ge De Industry Co | Unlicensed |
| Son Son | JP | 1986-02 |
Capcom | Commercial |
| Song of Morus - Favoured Cleric | WORLD | |
| Unlicensed |
| Sonic 3D Blast 6 | TW | 1997 |
| Unlicensed |
| Sonic The Hedgehog | TW | |
| Unlicensed |
| Sonik Gem Dash | WORLD | |
| Unlicensed |
| Soreike! Anpanman - Minna de Hiking Game! | JP | 1992-03-20 |
Bandai | Commercial |
| Sou Setsu Ryuu II - The Revenge | JP | 1989-12 |
Acclaim Entertainment | Prototype |
| Soul Stone | WORLD | |
| Demo |
| Space Blaze | WORLD | |
| Unlicensed |
| Space Harrier | JP | 1989-01-06 |
Sega | Commercial |
| Space Hunter | JP | 1986-09-25 |
Kemco | Commercial |
| Space Hunter | JP | 1986-09-25 |
Kemco | Prototype |
| Space Invaders | JP | 1985-04-17 |
Taito | Commercial |
| Space Mutants | DK | 2023-03 |
Tim Moore | Unlicensed |
| Space Mutants | WORLD | 2023-03 |
Tim Moore | Unlicensed |
| Space Mutants II | WORLD | |
T-bone#1 | Prototype |
| Space Parody | WORLD | |
| Unlicensed |
| Space Raft | WORLD | 2020 |
| Demo |
| Space Shadow | JP | 1989-02-20 |
Bandai | Commercial |
| Space Shuttle Project | US | 1991-11 |
Absolute Entertainment | Commercial |
| Space Soviets | WORLD | 2023-04 |
Vectrex28 | Prototype |
| Space Walk 3030 | WORLD | 2020-09 |
jcramer | Unlicensed |
| Spacegulls | WORLD | 2021-02 |
Morphcat Games | Unlicensed |
| Spacepunk'd | WORLD | |
| Demo |
| Spacey McRacey | WORLD | 2016 |
Bite The Chili Productions | Unlicensed |
| Spacin' Gators II - The 3rd One! | WORLD | |
| Demo |
| Sparkle Panda Rainbow Hunter | WORLD | |
| Demo |
| Sparky's Return | WORLD | |
| Prototype |
| Spartan X | JP | 1985-06-21 |
Nintendo | Commercial |
| Spartan X 2 | JP | 1991-09-27 |
Irem | Commercial |
| Speed Shoes | WORLD | 2025-01 |
DobyGames | Unlicensed |
| Speed Shoes 7 | WORLD | |
| Unlicensed |
| Spelunker | EU | 1985-12-07 |
Brøderbund Software | Commercial |
| Spelunker | JP | 1985-12-07 |
Brøderbund Software | Commercial |
| Spelunker | US | 1987-09 |
Brøderbund Software | Commercial |
| Spelunker II - Yuusha e no Chousen | JP | 1987-09 |
Irem | Commercial |
| Spider-Man - Return of the Sinister Six | AS | 1992-10 |
| Unlicensed |
| Spider-Man - Return of the Sinister Six | EU | 1992-11-29 |
LJN | Commercial |
| Spider-Man - Return of the Sinister Six | US | 1992-10 |
LJN | Commercial |
| Spiderman 2 | AS | 2004 |
| Unlicensed |
| Spin Master | US | |
| Unlicensed |
| Spirit Impel | WORLD | 2021-05 |
Passe Gaming | Unlicensed |
| Spiritual Guardian - Shock | WORLD | |
| Unlicensed |
| Spiritual Warfare | US | 1992 |
Wisdom Tree | Prototype |
| Spiritual Warfare | US | 1992 |
Wisdom Tree | Unlicensed |
| SplatooD | WORLD | 2015 |
| Unlicensed |
| Splatterhouse - Wanpaku Graffiti | JP | 1989-07-31 |
Namco | Commercial |
| Splatterhouse - Wanpaku Graffiti | WORLD | 1989-07-31 |
Namco | Commercial |
| Splatterworld - Rick to Kyoufu no Daiou | JP | |
Namco | Prototype |
| Split Second | WORLD | |
| Unlicensed |
| Spooky Soccer | WORLD | 2022-10 |
| Prototype |
| Spooky Soccer | WORLD | 2022-10 |
| Unlicensed |
| Spot | JP | 1992-10 |
Arcadia Systems | Commercial |
| Spot - The Video Game | US | 1990-09 |
Arcadia Systems | Commercial |
| Sprunkii - Color Match | WORLD | |
| Unlicensed |
| Spy Hunter | US | 1987-09 |
Sunsoft | Commercial |
| Spy vs Spy | EU | 1990-07-27 |
Kemco | Commercial |
| Spy vs Spy | JP | 1986-04-26 |
Kemco | Commercial |
| Spy vs Spy | US | 1988-10 |
Kemco | Commercial |
| Spy vs Spy II - The Island Caper | US | 1987-03 |
Kemco | Prototype |
| Sqoon | JP | 1986-06-26 |
Irem | Commercial |
| Sqoon | US | 1987-09 |
Irem | Commercial |
| Square Deal | JP | 1991-10 |
HectorSoft | Demo |
| Square no Tom Sawyer | JP | 1989-11-30 |
Square Enix | Commercial |
| Squashed | US | 1991-03 |
Jaleco | Prototype |
| Squatch Quest | WORLD | |
| Demo |
| Squirell Chaser | WORLD | |
| Unlicensed |
| Squirrel Domino | WORLD | |
| Unlicensed |
| Squirrel Domino | WORLD | |
| Prototype |
| Squish - The Bouncing Cat Ball | WORLD | |
| Unlicensed |
| Stack-Up | WORLD | 1985-07-26 |
Nintendo | Commercial |
| Stadium Events | EU | 1990-02-23 |
Bandai | Commercial |