| Shoukoushi Ceddie | JP | 1988-12-24 |
Fuji Television | Commercial |
| Shounen Ashibe - Nepal Daibouken no Maki | JP | 1991-11 |
Takara | Commercial |
| Shuang Yue Zhuan | CN | |
| Unlicensed |
| Shuangxiang Pao | TW | |
| Unlicensed |
| Shudu & Wuziqi | CN | |
| Unlicensed |
| Shuffle Fight | JP | 1992-10-09 |
Banpresto | Commercial |
| Shufflepuck Cafe | JP | 1990-10-21 |
Pony Canyon | Commercial |
| Shui Guo Li | AS | 1988 |
| Unlicensed |
| Shui Guo Li | TW | 1988 |
Home Entertainment Suppliers | Unlicensed |
| Shuiguan Pipe | AS | 1992-01 |
| Unlicensed |
| Shuihu III | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Shuihu Shenshou | CN | |
Shenzhen Nanjing Technology | Unlicensed |
| Shuihu Xin Zhuan | CN | |
| Unlicensed |
| Shuihu Zhuan | CN | |
| Unlicensed |
| Shuihu Zhuan - Marsh Outlaws | CN | |
| Unlicensed |
| Shuma Baobei | CN | |
| Unlicensed |
| Shuma Baolong 4 - Shuijing Ban | CN | 2004 |
| Unlicensed |
| Shuma Baolong III | CN | |
| Unlicensed |
| Shuma Zhandui II | CN | |
| Unlicensed |
| Siamond | WORLD | |
| Prototype |
| Side Pocket | AS | 1987-10-30 |
Data East | Unlicensed |
| Side Pocket | EU | 1992-05-27 |
Data East | Commercial |
| Side Pocket | JP | 1987-10-30 |
Data East | Commercial |
| Side Pocket | RU | 1992-05-27 |
| Unlicensed |
| Side Pocket | US | 1987-06 |
Data East | Commercial |
| Sidewinder | AU | 1989 |
Bunch Games | Unlicensed |
| Sidewinder | TW | 1989 |
Bunch Games | Unlicensed |
| Signal Test | WORLD | |
| Demo |
| Silent Assault | AS | 1990 |
Color Dreams | Unlicensed |
| Silent Assault | US | 1990 |
Color Dreams | Unlicensed |
| Silent Service | EU | 1990-11-23 |
Konami | Commercial |
| Silent Service | US | 1989-12 |
Konami | Commercial |
| Silk 2 | AS | |
| Unlicensed |
| Silk Worm | US | 1990-06 |
Sammy | Commercial |
| Silk Worm | US | 1990-06 |
American Sammy | Demo |
| Silu Chuanqi | CN | |
| Unlicensed |
| Silva Saga | JP | 1992-07-24 |
SETA | Commercial |
| Silver Eagle | TW | 1993 |
Sachen | Unlicensed |
| Silver Surfer | US | 1990-11 |
Arcadia Systems | Commercial |
| Silver Surfer | WORLD | 1990-11 |
Arcadia Corporation | Commercial |
| SimCity | US | 1991 |
Nintendo | Prototype |
| Simone Says | WORLD | |
| Prototype |
| Sinking Feeling | WORLD | |
| Unlicensed |
| Sir Ababol | WORLD | 2013-12 |
The Mojon Twins | Unlicensed |
| Sistema Cyber | WORLD | |
| Unlicensed |
| Skate Boy | AS | 1992-01-01 |
Gluk Video | Unlicensed |
| Skate Boy | EU | 1992-01-01 |
Gluk Video | Unlicensed |
| Skate Scramble | WORLD | |
| Unlicensed |
| Skate or Die | EU | 1990-08-17 |
Ultra Games | Commercial |
| Skate or Die | US | 1988-12 |
Ultra Games | Commercial |
| Skate or Die 2 - The Search for Double Trouble | US | 1990-09 |
Electronic Arts | Commercial |
| SkateCat | WORLD | 2023-03 |
Limited Run Games | Demo |
| Ski Pirates | WORLD | |
| Prototype |
| Ski or Die | EU | 1991-10-24 |
Ultra Games | Commercial |
| Ski or Die | US | 1988-12 |
Ultra Games | Commercial |
| Ski or Die | US | 1988-12 |
Ultra Games | Prototype |
| Sklad No18 | RU | 1997 |
| Unlicensed |
| Skull & Crossbones | KR | 1990 |
Tengen | Unlicensed |
| Skull & Crossbones | US | 1990 |
Tengen | Prototype |
| Skull & Crossbones | US | 1990 |
Tengen | Unlicensed |
| Sky - Sun and Clouds | WORLD | |
| Unlicensed |
| Sky Destroyer | JP | 1985-11-14 |
Taito | Commercial |
| Sky Diver | US | |
| Unlicensed |
| Sky Invader | AS | |
| Unlicensed |
| Sky Kid | JP | 1986-08-22 |
Namco | Commercial |
| Sky Kid | US | 1987-09 |
Namco | Commercial |
| Sky Kid | WORLD | 1986-08-22 |
Namco | Commercial |
| Sky Shark | US | 1989-09 |
Taito | Commercial |
| Sky Shark | WORLD | 1989-09 |
Taito | Commercial |
| SkyBound Quest | WORLD | |
| Demo |
| Slalom | EU | 1987-10-15 |
Nintendo | Commercial |
| Slalom | US | 1987-08 |
Nintendo | Commercial |
| Slappin' Bitches | WORLD | 2011 |
Right Nut Games | Unlicensed |
| Slaughter | WORLD | |
| Prototype |
| Slice of Bread | WORLD | |
| Prototype |
| Slow Mole | WORLD | 2021-07 |
Erik Rosenlund | Unlicensed |
| Smash T.V | EU | 1991-09 |
Acclaim Entertainment | Commercial |
| Smash T.V | US | 1991-09 |
Acclaim Entertainment | Commercial |
| Snackventure | WORLD | |
| Demo |
| Snail Maze | WORLD | |
| Unlicensed |
| SnailNES | WORLD | 2022-07 |
skRap Klan | Unlicensed |
| Snailo! | WORLD | 2025-01 |
DobyGames | Unlicensed |
| Snake Eyes | WORLD | |
| Unlicensed |
| Snake Off | WORLD | 2022-05 |
Johnybot | Unlicensed |
| Snake Rattle n Roll | EU | 1991-03-27 |
Nintendo | Commercial |
| Snake Rattle n Roll | US | 1990-07 |
Nintendo | Commercial |
| Snake's Revenge | EU | 1992-03-26 |
Ultra Games | Commercial |
| Snake's Revenge | US | 1990-04 |
Ultra Games | Commercial |
| Snakey Farm | WORLD | |
| Prototype |
| Snakky | WORLD | |
Piko Interactive | Unlicensed |
| Sneak 'n Peak | US | 2011-01 |
retroUSB | Unlicensed |
| Snoopy's Silly Sports Spectacular! | US | 1990-04 |
Kemco | Commercial |
| Snow Brawl | WORLD | |
| Prototype |
| Snow Bros | JP | 1991-12 |
Capcom | Commercial |
| Snow Brothers | EU | 1991-11 |
Capcom | Commercial |
| Snow Brothers | US | 1991-11 |
Capcom | Commercial |
| Snowball Blaster | WORLD | |
| Unlicensed |
| Snowboard Challenge | EU | 1990-06 |
Parker Brothers | Commercial |
| Soap Panic | JP | 1991 |
Panesian | Unlicensed |
| Soccer | AS | 1985-04-09 |
| Unlicensed |