| Mermaid | AS | |
| Unlicensed |
| Mermaids of Atlantis - The Riddle of the Magic Bubble | US | 1991 |
American Video Entertainment | Unlicensed |
| Mermay's Den - Deep Sea Escape | WORLD | |
| Prototype |
| Merry Moons | WORLD | |
| Unlicensed |
| Metal Arms | JP | 1990-01 |
Dempa Shinbunsha | Unlicensed |
| Metal Fighter | US | 1989 |
Color Dreams | Unlicensed |
| Metal Fighter Mu | AS | 1989 |
Color Dreams | Unlicensed |
| Metal Fighter Mu | JP | 1989 |
Color Dreams | Unlicensed |
| Metal Flame - Psy Buster | JP | 1990-12 |
Jaleco | Commercial |
| Metal Force | KR | 1993 |
Daou Infosys | Unlicensed |
| Metal Gear | EU | 1989-12-13 |
Konami | Commercial |
| Metal Gear | JP | 1987-12-22 |
Konami | Commercial |
| Metal Gear | US | 1988-06 |
Konami | Commercial |
| Metal Max | JP | 1991-05-24 |
Data East | Commercial |
| Metal Max | JP | 1991-05-24 |
Data East | Prototype |
| Metal Slader Glory | JP | 1991-08-30 |
HAL Laboratory | Commercial |
| Metal Slug Advance | CN | 2005 |
| Unlicensed |
| Metal Storm | US | 1991-02 |
Irem | Commercial |
| Metal Storm | WORLD | 1991-02 |
Irem | Commercial |
| MetalMech - Man & Machine | US | 1991-03 |
Jaleco | Commercial |
| MetalMech - Man & Machine | WORLD | 1990-12 |
Jaleco | Commercial |
| Meteor Guard | WORLD | |
| Prototype |
| Meteor Guard 2 | WORLD | |
| Prototype |
| Meteor Swarm | US | |
| Unlicensed |
| Metro-Cross | JP | 1986-12-16 |
Namco | Commercial |
| Metroid | EU | 1988-01-15 |
Nintendo | Commercial |
| Metroid | US | 1986-08 |
Nintendo | Commercial |
| Mewtwo no Pokemon II | AS | |
| Unlicensed |
| Mezase Pachi Pro - Pachio-kun | JP | 1987-12-18 |
Coconuts Japan | Commercial |
| Mezase Pachi Pro - Pachio-kun | JP | 1987-12-18 |
Coconuts Japan | Prototype |
| Mezase! Top Pro - Green ni Kakeru Yume | JP | 1993-03-05 |
Jaleco | Commercial |
| Mi Hun Che | TW | 1988 |
RCM Group | Unlicensed |
| MiG 29 - Soviet Fighter | EU | 1992 |
Codemasters | Unlicensed |
| MiG 29 - Soviet Fighter | US | 1992 |
Codemasters | Unlicensed |
| Michael Andretti's World GP | US | 1990-06 |
Sammy | Commercial |
| Mick & Mack as the Global Gladiators | US | 1993 |
Virgin Games | Prototype |
| Mickey Mania 7 | TW | 1997 |
J.Y. Company | Unlicensed |
| Mickey Mouse - Dream Balloon | US | 1992 |
Kemco | Prototype |
| Mickey Mouse - Fushigi no Kuni no Daibouken | AS | 1987-03 |
| Unlicensed |
| Mickey Mouse - Fushigi no Kuni no Daibouken | JP | 1987-03 |
Capcom | Commercial |
| Mickey Mouse III - Yume Fuusen | JP | 1992-09-30 |
Kemco | Commercial |
| Mickey Mousecapade | US | 1988-10 |
Capcom | Commercial |
| Mickey's Adventure in Numberland | US | 1994-03 |
HiTech Software | Commercial |
| Mickey's Adventure in Numberland | US | 1994-03 |
Hi Tech Expressions | Prototype |
| Mickey's Safari in Letterland | US | 1993-03 |
Hi Tech Expressions | Commercial |
| Micro Knight | WORLD | |
| Unlicensed |
| Micro Knight - Revenge of the Four Skulls | WORLD | |
| Unlicensed |
| Micro Knight II | WORLD | |
| Unlicensed |
| Micro Knight IV | WORLD | |
| Unlicensed |
| Micro Machines | EU | 1992 |
Codemasters | Unlicensed |
| Micro Machines | US | 1992 |
Codemasters | Unlicensed |
| Micro Mages | WORLD | 2019-02-12 |
Morphcat Games | Demo |
| Midnight Jogger | WORLD | |
| Prototype |
| Midnight Zone | WORLD | |
| Demo |
| MiedoW | WORLD | 2018 |
| Unlicensed |
| Might & Magic - Secret of the Inner Sanctum | US | 1992-08 |
New World Computing | Commercial |
| Might and Magic - Book One - Secret of the Inner Sanctum | JP | 1990-07 |
New World Computing | Commercial |
| Mighty Bomb Jack | EU | 1992 |
Tecmo | Commercial |
| Mighty Bomb Jack | JP | 1986-04-24 |
Tecmo | Commercial |
| Mighty Bomb Jack | TW | 1986-04-24 |
| Unlicensed |
| Mighty Bomb Jack | US | 1987-07 |
Tecmo | Commercial |
| Mighty Final Fight | EU | 1993-12-02 |
Capcom | Commercial |
| Mighty Final Fight | JP | 1993-06-11 |
Capcom | Commercial |
| Mighty Final Fight | US | 1993-07 |
Capcom | Commercial |
| Mighty Morphin - Power Rangers III | TW | 1995-04 |
| Unlicensed |
| Mighty Morphin - Power Rangers IV - The Movie | TW | |
| Unlicensed |
| Mihu Che | AS | |
| Unlicensed |
| Mike Ditka's Big Play Football | US | 1989-12 |
| Unlicensed |
| Mike Tyson's Intergalactic Power Punch | US | 1992-06 |
Beam Software | Prototype |
| Mike Tyson's Punch-Out!! | AS | 1987-11-21 |
| Unlicensed |
| Mike Tyson's Punch-Out!! | EU | 1987-12-15 |
Nintendo | Commercial |
| Mike Tyson's Punch-Out!! | JP | 1987-11-21 |
Nintendo | Commercial |
| Mike Tyson's Punch-Out!! | US | 1987-10 |
Nintendo | Commercial |
| MilioNESy | WORLD | 2014-05 |
NintendoAge | Unlicensed |
| Millionaire | TW | 1990 |
Sachen | Unlicensed |
| Millipede | JP | 1987-10-01 |
HAL Laboratory | Prototype |
| Millipede | US | 1988-10 |
HAL Laboratory | Commercial |
| Millipede | US | 1988-10 |
HAL Laboratory | Unlicensed |
| Millipede - Kyodai Konchuu no Gyakushuu | JP | 1987-10 |
HAL Laboratory | Commercial |
| Milon's Secret Castle | US | 1988-09 |
Hudson Soft | Commercial |
| Minccraft | WORLD | |
| Prototype |
| Mindblower Pak | AU | 1990 |
Home Entertainment Suppliers | Unlicensed |
| Mindkids 114-in-1 | CN | |
| Unlicensed |
| Mindseeker | JP | 1989-04-18 |
Namco | Commercial |
| Mine Mayhem | WORLD | 2021-04 |
FG Software | Unlicensed |
| Mine Shaft | WORLD | 2012-01 |
Nioreh | Unlicensed |
| Minekart Madness | WORLD | 2022-11 |
| Unlicensed |
| Minelvaton Saga - Ragon no Fukkatsu | JP | 1987-10-23 |
Taito | Commercial |
| Miner | WORLD | |
| Unlicensed |
| Mini-Putt | JP | 1991-02-15 |
A Wave | Commercial |
| Mini-Putt | US | 1991-02-15 |
A Wave | Prototype |
| Minna no Taabou no Nakayoshi Daisakusen | JP | 1991-11 |
Character Soft | Commercial |
| Minnade Mamotte Knight - Amazon's Running Diet | WORLD | 2017 |
Ancient | Unlicensed |
| Miracle Ropit's - 2100 Nen no Daibouken | JP | 1987-08 |
King Records | Commercial |
| Mirai Shinwa Jarvas | JP | 1987-06-30 |
Taito | Commercial |
| Miroh | WORLD | 2023-10 |
Wendel Scardua | Unlicensed |
| Mischief Castle | WORLD | 2024-08 |
Kn56k | Demo |
| Mischievous Crow | JP | |
| Unlicensed |
| Missing Lands | WORLD | 2017-04 |
| Unlicensed |
| Missing Lands DX | WORLD | |
| Unlicensed |