| Sludge Life | 2021 | switch |
| Smart Adventures - Mission Math - Sabotage at the Space Station | 2016 | wiiu |
| Smart Series Presents - Jaja's Adventure | 2010 | wii |
| Smarties - Meltdown | 2006 | ps2 |
| Smickeonn 2 - The Game | 2024 | gb |
| SmuggleCraft | 2017 | ps4 |
| Snake's Revenge | 1990 | nes |
| Snark Busters - High Society | 2014 | ps3 |
| Snatcher | 1994 | ps1, saturn, segacd |
| Snatcher CD-ROMantic | 1992 | pcengine |
| Snatcher CD-ROMantic - Pilot Disk | 1992 | pcengine |
| Sneak 'n Peak | 2011 | nes |
| Snoopy Concert | 1995 | snes |
| Snow | 2003 | dreamcast, ps2 |
| Snow Bound Land | 2013 | psp |
| Snow Portable | 2007 | psp |
| Snow White & the 7 Clever Boys | 2006 | ps2 |
| Snow White and the Seven Dwarfs | 1983 | a2600 |
| Snufkin: Melody of Moominvalley | 2024 | switch |
| So Blonde - Back to the Island | 2010 | nds, wii |
| Soi Kano - Gyutto Dakishimete | 2019 | vita |
| The Sojourn | 2019 | ps4, xboxone |
| Sole | 2019 | xboxone |
| Solfege - Sweet Harmony | 2008 | psp |
| Solomon's Ring - Hi no Shou | 2012 | psp |
| Solomon's Ring - Kaze no Shou | 2012 | psp |
| Solomon's Ring - Mizu no Shou | 2013 | psp |
| Solstice - Sanjigen Meikyuu no Kyoujuu | 1990 | nes |
| Solstice - The Quest for the Staff of Demnos | 1990 | nes |
| Solstice II | 1993 | snes |
| A Solution | 2025 | gb |
| Someday You'll Return | 2020 | ps4 |
| Son Son II | 1989 | pcengine |
| Song of the Deep | 2016 | xboxone |
| Sonic Adventure DX | 2003 | gc |
| Sonic The Hedgehog | 1996 | snes |
| Sora no Otoshimono - Doki Doki Summer Vacation | 2010 | psp |
| Sora no Otoshimono Forte - Dreamy Season | 2011 | nds |
| Sorairo Portable | 2012 | psp |
| Sorairo no Organ Remix | 2005 | ps2 |
| Sorayume | 2008 | ps2 |
| Sorayume | 2014 | vita |
| Sorayume Portable | 2009 | psp |
| Sorcerian - Shichisei Mahou no Shito | 2000 | dreamcast |
| Soshite Bokura wa, ... and He Said | 2005 | ps2 |
| Soshite Kono Sora ni Kirameku Kimi no Uta | 2006 | ps2 |
| Soshite Kono Sora ni Kirameku Kimi no Uta XXX | 2007 | ps2 |
| Sotsugyou - 2nd Generation | 2006 | ps2 |
| Sotsugyou Crossworld | 1997 | saturn |
| Sotsugyou Shashin - Miki | 1994 | pcengine |
| Sotsugyou Vacation | 1997 | ps1 |
| Soukoku no Kusabi - Hiiro no Kakera 3 | 2008 | ps2 |
| Soukoku no Kusabi - Hiiro no Kakera 3 - Ashita e no Tobira | | psp |
| Soukoku no Kusabi - Hiiro no Kakera 3 Portable | 2010 | psp |
| Soul Axiom | 2016 | ps4, wiiu, xboxone |
| Soul Link Extension | 2006 | ps2 |
| Sound Novel Evolution 1 - Otogirisou - Sosei-hen | 1999 | ps1 |
| Sound Novel Evolution 2 - Kamaitachi no Yoru Tokubetsu-hen | 1998 | ps1 |
| Sound Novel Evolution 3 - Machi - Unmei no Kousaten | 1999 | ps1 |
| Sound Novel Machi | 1998 | saturn |
| Sound Novel Tkool 2 | 1997 | ps1, saturn |
| Sound Novel Tsukuru | 1996 | snes |
| Soundtrap | 1994 | cdi |
| Sovereign of a Dying Hell | 2025 | genesis |
| The Space Adventure - Cobra - The Legendary Bandit | 1995 | segacd |
| Space Adventure Cobra - Kokuryuuou no Densetsu | 1989 | pcengine |
| Space Adventure Cobra II - Densetsu no Otoko | 1991 | pcengine |
| Space Fishermen | 2002 | ps2 |
| A Space for the Unbound | 2023 | ps4, switch |
| SpellCaster | 1988 | sms |
| SpellCraft - Aspects of Valor | 1993 | snes |
| Spice and Wolf VR | 2019 | switch |
| Spirit Hunter: Death Mark | 2018 | ps4, vita |
| Spirit Hunter: Death Mark II | 2022 | ps4, switch |
| Spirit Hunter: NG | 2019 | ps4, switch, vita |
| Spirit of the North | 2019 | ps4 |
| Spirit: Lucky's Big Adventure | 2021 | ps4, switch |
| Spiritual Warfare | 1994 | gb, genesis |
| Splash or Crash | 2013 | 3ds |
| SpongeBob SquarePants - Legend of the Lost Spatula | 2001 | gbc |
| SpongeBob SquarePants: The Patrick Star Game | 2024 | switch |
| Spot Goes to Hollywood | 1995 | snes |
| Springdale | 2010 | ps2, wii |
| Spy Fox in Dry Cereal | 2008 | wii |
| Squashed | 1991 | nes |
| Squids Odyssey | 2014 | 3ds, wiiu |
| Squirrel Falls | 2025 | gb |
| St. Luminous Jogakuin | 2000 | ps1 |
| Stacking | 2011 | ps3, xbox360 |
| Standby Say You! | 1997 | ps1, saturn |
| Stanley - The Search for Dr. Livingston | 1992 | nes |
| The Stanley Parable: Ultra Deluxe | 2022 | ps4, switch |
| Star Cruiser | 1990 | genesis |
| Star Heritage | | gbc |
| Star Melody: Yumemi Dreamer | 2022 | switch |
| Star Sky | 2015 | wiiu |
| Star Sky 2 | 2016 | wiiu |
| Star Trek - 25th Anniversary | 1992 | gb |
| Star Trek - 25th Anniversary | 1992 | nes |
| Star Trek - Deep Space Nine - Crossroads of Time | 1995 | genesis, snes |