| Shinsetsu Shiawase Usagi | 1995 | pcengine |
| Shinsetsu Shiawase Usagi 2 - Kairaku e no Invitation | 1996 | pcengine |
| Shinsetsu Shiawase Usagi f - Yuujou yorimo Aiyoku | 1997 | pcengine |
| Shinsetsu Yumemi Yakata - Tobira no Oku ni Dareka ga | 1994 | saturn |
| Shipwreck | 1993 | cdi |
| Shirachuu Tankenbu | 2003 | ps2 |
| Shirahana no Ori - Hiiro no Kakera 4 | 2012 | psp |
| Shirahana no Ori - Hiiro no Kakera 4 - Shiki no Uta | 2013 | psp |
| Shiratsuyu no Kai | 2013 | psp |
| Shiro to Kuro no Alice | 2017 | vita |
| Shiro to Kuro no Alice - Twilight Line | 2018 | vita |
| Shirogane no Cal to Aoi no Joou | 2011 | psp |
| Shirogane no Soleil - Contract to the Future - Mirai e no Keiyaku | 2008 | ps2 |
| Shirogane no Torikago - The Angels with Strange Wings | 2005 | ps2 |
| Shirokuma Bell Stars - Happy Holidays! | 2012 | psp |
| Shirotsumesouwa - Episode of the Clovers | 2003 | dreamcast |
| Shitsuji ga Aruji o Erabu Toki | 2016 | vita |
| Shokugeki no Soma - Yuujou to Kizuna no Hitosara | 2015 | 3ds |
| A Short Hike | 2020 | switch |
| Shoujo Kakumei Utena - Itsuka Kakumei Sareru Monogatari | 1998 | saturn |
| Shoujo Yoshitsune-den | 2003 | ps2 |
| Shoujo Yoshitsune-den Ni - Toki o Koeru Chigiri | 2005 | ps2 |
| Shoukoushi Ceddie | 1988 | nes |
| Shounen Ashibe - Nepal Daibouken no Maki | 1991 | nes |
| Shounen Onmyouji - Tsubasa yo Ima, Sora e Kaere | 2007 | ps2 |
| Shovel Knight: Pocket Dungeon | 2021 | ps4, switch |
| Shuffle! On the Stage | 2005 | ps2 |
| Shugo Chara! - 3-tsu no Tamago to Koisuru Joker | 2008 | nds |
| Shukufuku no Campanella Portable | 2010 | psp |
| Shuten Order | 2025 | switch |
| Shuumatsu Shoujo Gensou Alicematic - Apocalypse | 2008 | ps2 |
| Shuushoku Game | 1995 | snes |
| Side Kicks! | 2017 | vita |
| Signal | 2009 | nds |
| Silence: The Whispered World 2 | 2016 | ps4, xboxone |
| Silent Hill | 1999 | ps1 |
| Silent Hill Genesis | 2014 | genesis |
| Silent Moebius - Case - Titanic | 1998 | ps1 |
| Silent Moebius - Gen'ei no Datenshi | 1998 | ps1 |
| Silk to Cotton | 2002 | gba |
| Silt | 2022 | switch |
| The Silver Case | 2017 | ps4 |
| Silver Jiken - The Silver | 1999 | ps1 |
| Silverio Vendetta - Verse of Orpheus | 2016 | vita |
| Silverload | 1996 | ps1 |
| Simon the Sorcerer | 1994 | cd32 |
| Simoun - Ibara Sensou - Fuuin no Ri Maajon | 2007 | ps2 |
| Simple 1500 Series Vol. 31 - The Sound Novel | 2000 | ps1 |
| Simple 1500 Series Vol. 36 - The Ren'ai Simulation - Natsuiro Celebration | 2000 | ps1 |
| Simple 1500 Series Vol. 57 - The Meiro | 2001 | ps1 |
| Simple 1500 Series Vol. 59 - The Suiri - IT Tantei 18 no Jikenbo | 2001 | ps1 |
| Simple 1500 Series Vol. 71 - The Ren'ai Simulation 2 - Fureai | 2001 | ps1 |
| Simple 1500 Series Vol. 74 - The Horror Mystery - Sangeki-kan - Kevin Hakushaku no Fukkatsu | 2001 | ps1 |
| Simple 1500 Series Vol. 81 - The Ren'ai Adventure - Okaeri! | 2001 | ps1 |
| Simple 2000 Series DC Vol. 01 - Bittersweet Fools - The Ren'ai Adventure | 2002 | dreamcast |
| Simple 2000 Series DC Vol. 02 - Natsuiro Celebration - The Ren'ai Simulation | 2002 | dreamcast |
| Simple 2000 Series DC Vol. 03 - Fureai - The Ren'ai Simulation | 2002 | dreamcast |
| Simple 2000 Series DC Vol. 04 - Okaeri! The Ren'ai Adventure | 2002 | dreamcast |
| Simple 2000 Series Ultimate Vol. 11 - Wandaba Style - Totsugeki! Mix Live Juice | 2003 | ps2 |
| Simple 2000 Series Ultimate Vol. 27 - Houkago no Love Beat | 2004 | ps2 |
| Simple 2000 Series Vol. 123 - The Office Love Jikenbo - Reijou Tantei | 2007 | ps2 |
| Simple 2000 Series Vol. 13 - Onna no Ko no Tame no - The Ren'ai Adventure - Garasu no Mori | 2002 | ps2 |
| Simple 2000 Series Vol. 17 - The Suiri - Arata naru 20 no Jikenbo | 2002 | ps2 |
| Simple 2000 Series Vol. 19 - The Ren'ai Simulation - Watashi ni Oma-Cafe | 2002 | ps2 |
| Simple 2000 Series Vol. 29 - The Ren'ai Board Game - Seishun 18 Radio | 2003 | ps2 |
| Simple 2000 Series Vol. 34 - The Ren'ai Horror Adventure - Hyouryuu Shoujo | 2003 | ps2 |
| Simple 2000 Series Vol. 38 - Otoko no Tame no Bible - The Yuujou Adventure - Hotaru Soul | 2003 | ps2 |
| Simple 2000 Series Vol. 43 - The Saiban - Shinmai Shihoukan Momota Tsukasa no 10 no Saiban File | 2004 | ps2 |
| Simple 2000 Series Vol. 45 - The Koi to Namida to, Tsuioku to... Thread Colors - Sayonara no Mukougawa | 2004 | ps2 |
| Simple 2000 Series Vol. 58 - The Gekai | 2004 | ps2 |
| Simple 2000 Series Vol. 67 - The Suiri - Soshite Dare mo Inaku Natta | 2004 | ps2 |
| Simple 2000 Series Vol. 70 - The Kanshikikan | 2005 | ps2 |
| Simple 2000 Series Vol. 71 - The Fantasy Ren'ai Adventure - Kanojo no Densetsu, Boku no Sekiban | 2005 | ps2 |
| Simple 2000 Series Vol. 74 - Onna no Ko Sen'you - The Oujisama to Romance - Ripuru no Tamago | 2005 | ps2 |
| Simple 2000 Series Vol. 76 - The Hanasou Eigo no Tabi | 2005 | ps2 |
| Simple 2000 Series Vol. 84 - The Boku ni Oma-Cafe - Kimagure Strawberry Cafe | 2003 | ps2 |
| Simple 2000 Series Vol. 9 - The Ren'ai Adventure - Bittersweet Fools | 2002 | ps2 |
| Simple 2000 Series Vol. 92 - The Noroi no Game | 2005 | ps2 |
| Simple 2000 Series Vol. 97 - The Koi no Engine - Darling Special Backlash - Koi no Exhaust Heat | 2004 | ps2 |
| Simple DS Series Vol. 15 - The Kanshikikan 2 - Aratanaru Yattsu no Jiken o Touch Seyo | 2007 | nds |
| Simple DS Series Vol. 41 - The Bakudan Shorihan | 2008 | nds |
| Simple DS Series Vol. 42 - The Haioku Byoutou - Norowareta Byouin kara no Dasshutsu | 2008 | nds |
| Simple DS Series Vol. 47 - The Suiri - Shinshou 2009 | 2009 | nds |
| Simple DS Series Vol. 48 - The Saibanin - 1-tsu no Shinjitsu, 6-tsu no Kotae | 2009 | nds |
| Simple DS Series Vol. 8 - The Kanshikikan - Kinkyuu Shutsudou! Jiken Genba o Touch Seyo! | 2006 | nds |
| Simple Series Vol. 4 - The Misshitsu kara no Dasshutsu | 2009 | wii |
| Simulacra | 2019 | ps4, xboxone |
| Sister Princess | 2001 | ps1 |
| Sister Princess - Premium Edition | 2002 | dreamcast |
| Sister Princess - Pure Stories | 2001 | ps1 |
| Sister Princess - RePure | 2003 | gba |
| Sister Princess 2 | 2003 | ps1 |
| Sister Princess 2 - Premium Fan Disc | 2003 | ps1 |
| Skip Beat! | 2009 | ps2 |
| Skylar & Plux: Adventure on Clover Island | 2017 | xboxone |
| Skylight Freerange | 2017 | vita |
| Skylight Freerange 2 - Gachduine | 2016 | vita |
| Slayers Royal | 1997 | ps1, saturn |
| Slayers Royal 2 | 1999 | ps1 |
| Slime Rancher: Plortable Edition | 2021 | switch |