| Star Trek - The Next Generation - Echoes from the Past | 1994 | genesis |
| Star Trek - The Next Generation - Future's Past | 1994 | snes |
| Star Trek: Bridge Crew | 2017 | ps4 |
| Star Wars - Jedi Power Battles | 2001 | gba |
| Star Wars - The New Droid Army | 2002 | gba |
| Star Wars - Yoda Stories | 1999 | gbc |
| Star Wars Episode I - Obi-Wan's Adventures | 2000 | gbc |
| StarTRain - Your Past Makes Your Future | 2007 | ps2 |
| StarTropics | 1990 | nes |
| StarTropics | 2008 | wii |
| Starbound | | xboxone |
| Starry Sky - After Spring Portable | 2012 | psp |
| Starry Sky - After Summer Portable | 2013 | psp |
| Starry Sky - After Winter Portable | 2013 | psp |
| Starry Sky - Autumn Stories | 2017 | vita |
| Starry Sky - In Autumn Portable | 2010 | psp |
| Starry Sky - In Spring Portable | 2010 | psp |
| Starry Sky - In Summer Portable | 2010 | psp |
| Starry Sky - In Winter Portable | 2011 | psp |
| Starry Sky - Spring Stories | 2016 | vita |
| Starry Sky - Summer Stories | 2017 | vita |
| Starry Sky - Winter Stories | 2017 | vita |
| State of Mind | 2018 | ps4, switch, xboxone |
| The Station | 2018 | xboxone |
| Stay | 2018 | ps4, vita, xboxone |
| Steady x Study | 2004 | ps2 |
| Steam Prison | 2021 | switch |
| Steam Prison - Nanatsu no Bitoku | 2017 | vita |
| Steam-Heart's | 1996 | pcengine |
| Steins;Gate | 2009 | ps3, psp, vita, xbox360 |
| Steins;Gate - Hiyoku Renri no Darling | 2012 | ps3 |
| Steins;Gate - Hiyoku Renri no Darling | 2011 | psp, vita, xbox360 |
| Steins;Gate - Linear Bounded Phenogram | 2013 | ps3 |
| Steins;Gate - Senkei Kousoku no Phenogram | 2013 | ps3, xbox360 |
| Steins;Gate 0 | 2015 | ps3, ps4, switch, vita |
| Steins;Gate 0 | 2017 | xboxone |
| Steins;Gate Elite | 2018 | ps4, switch, vita |
| Steins;Gate: My Darling's Embrace | 2019 | ps3, ps4, switch |
| Stellar Theater Portable | 2013 | psp |
| Stifled | 2017 | ps4 |
| Still Life | 2005 | xbox |
| The Stillness of the Wind | 2019 | switch |
| Stone | 2020 | xboxone |
| Stone Shire | 2015 | wiiu |
| Stone Walkers | 1996 | ps1 |
| Stories Untold | 2020 | ps4, switch, xboxone |
| Storm Boy | 2018 | ps4, xboxone |
| Storm Lover | 2010 | psp |
| Storm Lover 2nd | 2013 | psp |
| Storm Lover Natsukoi!! | 2011 | psp |
| StormLover | | psp |
| StormLover Kai!! | 2012 | psp |
| Story Hour - Adventures | 2009 | wii |
| Story Hour - Fairy Tales | 2008 | wii |
| The Story of Noah's Ark | 2009 | nds |
| Strahl | 1994 | 3do |
| Strawberry Nauts | 2016 | vita |
| Strawberry Panic! | 2006 | ps2 |
| Strawberry Shortcake - Summertime Adventure | 2004 | gba |
| Strawberry Shortcake - Summertime Adventure - Special Edition | 2005 | gba |
| Strawberry Shortcake - Sweet Dreams | 2006 | gba |
| Stray | 2022 | ps4, switch |
| Street Fighter II Movie | 1995 | ps1, saturn |
| Strike Witches 2 - Iyasu, Naosu, Punipuni Suru | 2010 | nds |
| Strip-Poker Pro | 1994 | cdi |
| Strong Bad's Cool Game for Attractive People - Episode 1 - Homestar Ruiner | 2008 | ps3, wii |
| Strong Bad's Cool Game for Attractive People - Episode 2 - StrongBadia the Free | 2008 | ps3, wii |
| Strong Bad's Cool Game for Attractive People - Episode 3 - Baddest of the Bands | 2008 | ps3, wii |
| Strong Bad's Cool Game for Attractive People - Episode 4 - Dangeresque 3 - The Criminal Projective | 2008 | wii |
| Strong Bad's Cool Game for Attractive People - Episode 5 - 8-Bit Is Enough | 2008 | ps3, wii |
| Stupid Invaders | 2001 | dreamcast |
| SuGirly Wish | | psp |
| SuGirly Wish Limited | 2012 | psp |
| Subete ga F ni Naru - The Perfect Insider | 2002 | ps1 |
| Subject 13 | 2017 | xboxone |
| Submerged | 2015 | ps4, xboxone |
| Subsurface Circular | 2018 | switch |
| Suchie-Pai Adventure - Doki Doki Nightmare | 1998 | saturn |
| Sucre Portable | 2012 | psp |
| Sugar + Spice! Ano Ko no Suteki na Nani mo Kamo | 2008 | ps2 |
| Sui Sui Sweet - Amai Koi no Mitsukekata | 2003 | ps2 |
| The Suicide of Rachel Foster | 2020 | ps4 |
| Suigetsu - Mayoigokoro | 2004 | dreamcast |
| Suigetsu - Mayoigokoro | 2004 | ps2 |
| Suigetsu 2 | 2012 | ps3 |
| Suigetsu Ni Portable | 2012 | psp |
| Suigetsu Portable | 2008 | psp |
| Suika | 2002 | dreamcast |
| Suika A.S+ - Eternal Name | 2007 | ps2 |
| Suishou no Dragon | 1986 | fds |
| The Suite Life of Zack & Cody - Tipton Caper | 2006 | gba |
| Suizokukan Project - Fish Hunter e no Michi | 1999 | ps1 |
| Suki na Mono wa Suki dakara Shou ga Nai!! First Limit & Target Nights - Sukishou! Episode 01+02 | 2004 | ps2 |
| Suki na Mono wa Suki dakara Shou ga Nai!! Rain - Sukishou! Episode 03 | 2004 | ps2 |
| Suki to Suki to de Sankaku Ren'ai | 2019 | vita |
| Sukiya | 2021 | genesis |
| Sumire | 2021 | switch |
| Summer Pockets | 2019 | switch |
| Summer Time Rendering: Another Horizon | 2023 | ps4, switch |
| Summer in Mara | 2020 | ps4, switch |