| Sunless Sea: Zubmariner Edition | 2020 | switch |
| Super Adventure Quests | 1991 | nes |
| Super Adventure Rockman | 1998 | saturn |
| Super Castlevania IV | 2006 | wii |
| Super Chinese Land | 1990 | gb |
| Super Chinese Land 2 | 1991 | gb |
| Super Contra X | 1994 | nes |
| Super Daikoukai Jidai | 1992 | snes |
| Super Dangan-Ronpa 2 - Sayonara Zetsubou Gakuen | 2012 | psp |
| Super Danganronpa 2 - Sayonara Zetsubou Gakuen | 2012 | psp |
| Super Doll Licca-chan - Kisekae Daisakusen | 2000 | gbc |
| Super Gals! Kotobuki Ran | 2001 | gbc |
| Super Ghouls 'n Ghosts | 2007 | wii |
| Super Impostor Bros | 2021 | gbc |
| Super Me-Mail GB - Me-Mail Bear no Happy Mail Town | 2000 | gbc |
| The Super Model - Gail McKenna | 1995 | 3do |
| Super Pitfall II | 1986 | nes |
| Super Wonder Boy - Monster World | 1988 | sms |
| SuperLite 1500 Series - Emmyrea | 2002 | ps1 |
| SuperLite 1500 Series - Flamberge no Seirei | 2001 | ps1 |
| SuperLite 1500 Series - Kouyasai - A Sherd of Youthful Memories | 2002 | ps1 |
| SuperLite 1500 Series - Makikou | 2001 | ps1 |
| SuperLite 1500 Series - Memories Off | 2000 | ps1 |
| SuperLite 1500 Series - Nobunaga Hiroku - Geten no Yume | 2000 | ps1 |
| SuperLite 1500 Series - Prismaticallization | 2002 | ps1 |
| SuperLite 1500 Series - Ring of Sias | 2000 | ps1 |
| SuperLite 1500 Series - Screen | 2001 | ps1 |
| SuperLite 1500 Series - Shinsei Toilet no Hanako-san | 1999 | ps1 |
| SuperLite 2000 Vol. 20 - Omoide ni Kawaru Kimi - Memories Off | 2004 | ps2 |
| SuperLite 2000 Vol. 21 - Konohana Pack - 3-tsu no Jikenbo | 2004 | ps2 |
| SuperLite 2000 Vol. 22 - Memories Off Duet | 2004 | ps2 |
| SuperLite 2000 Vol. 23 - Never 7 - The End of Infinity | 2008 | ps2 |
| SuperLite 2000 Vol. 24 - Ever 17 - The Out of Infinity - Premium Edition | 2004 | ps2 |
| SuperLite 2000 Vol. 29 - Memories Off Mix | 2005 | ps2 |
| SuperLite 2000 Vol. 31 - Remember 11 - The Age of Infinity | 2005 | ps2 |
| SuperLite 2000 Vol. 32 - Ai yori Aoshi | 2005 | ps2 |
| SuperLite 2000 Vol. 33 - Memories Off - Sorekara | 2005 | ps2 |
| SuperLite 2000 Vol. 34 - Akai Ito | 2004 | ps2 |
| SuperLite 2000 Vol. 35 - Monochrome | 2005 | ps2 |
| SuperLite 2000 Vol. 37 - Memories Off - After Rain Vol. 1 - Orizuru | 2006 | ps2 |
| SuperLite 2000 Vol. 38 - Memories Off - After Rain Vol. 2 - Souen | 2006 | ps2 |
| SuperLite 2000 Vol. 39 - Konohana 4 - Yami o Harau Inori | 2004 | ps2 |
| SuperLite 2000 Vol. 40 - Memories Off - After Rain Vol. 3 - Sotsugyou | 2006 | ps2 |
| SuperLite 2000 Vol. 42 - Memories Off 5 - Togireta Film | 2006 | ps2 |
| SuperLite 2000 Vol. 43 - Memories Off - Sorekara Again | 2007 | ps2 |
| SuperLite 2000 Vol. 44 - Aoi Shiro | 2009 | ps2 |
| SuperLite 2000 Vol. 6 - Konohana 2 - Todokanai Requiem | 2003 | ps2 |
| SuperModels Go Wild | 1994 | 3do |
| Superbrothers: Sword & Sworcery EP | 2018 | switch |
| Superman | 1978 | a2600 |
| Supervivientes | 2009 | nds |
| Suran Digit | 2016 | vita |
| Surf City | 1994 | cdi |
| Surgical Strike | 1995 | segacd |
| Surveillance - Kanshisha | 2002 | ps2 |
| Survival Island | 1983 | a2600 |
| Survivor | 2009 | nds |
| Survivor 3D - The Ultimate Adventure | 2012 | 3ds |
| Suzerain | 2020 | switch |
| Suzukaze no Melt - Days in the Sanctuary | 2011 | ps3 |
| Suzukaze no Melt - Days in the Sanctuary | 2012 | psp |
| Suzumiya Haruhi no Chokuretsu | 2009 | nds |
| Suzumiya Haruhi no Heiretsu | 2009 | wii |
| Suzumiya Haruhi no Tsuisou | 2011 | ps3, psp |
| Suzumiya Haruhi no Yakusoku | 2007 | psp |
| Suzunone Seven! Portable | 2014 | psp |
| Suzunone Seven! Rebirth Knot | 2010 | ps2 |
| Sweet Fuse - At Your Side | 2013 | psp |
| Sweet Honey Coming | 2009 | ps2 |
| Sweet Legacy - Boku to Kanojo no Na mo Nai Okashi | 2002 | ps2 |
| Sweet Pool | 2018 | vita |
| Sweet Season | 2005 | ps2 |
| Switch | 2002 | ps2 |
| Sword Master | 1990 | nes |
| Sword of Saros | 1983 | a2600 |
| SwordQuest - EarthWorld | 1982 | a2600 |
| SwordQuest - FireWorld | 1983 | a2600 |
| SwordQuest - WaterWorld | 1983 | a2600 |
| Swordbreaker - The Game | 2020 | vita |
| Syberia | 2008 | nds |
| Syberia | 2003 | ps2, ps3, switch, xbox, xbox360 |
| Syberia 2 | 2017 | switch |
| Syberia 3 | 2017 | ps4, switch, xboxone |
| Syberia Collection | 2015 | ps3 |
| Syberia II | 2004 | ps2, ps3, xbox |
| Sydney Hunter and the Caverns of Death | 2017 | snes |
| Sylvanian Families - Otogi no Kuni no Pendant | 1999 | gbc |
| Sylvester and Tweety | 1993 | snes |
| Sympathy Kiss | 2022 | switch |
| Symphonic Rain | 2018 | switch |
| Synergia | 2021 | vita |
| Syrup and The Ultimate Sweet | 2020 | ps4, vita, xboxone |
| TIZ - Tokyo Insect Zoo | 1996 | ps1 |
| TM Network - Live in Power Bowl | 1989 | nes |
| TOHU | 2021 | ps4 |
| TOHU | 2021 | xboxone |
| Tabaluga | 1999 | gbc |
| Tacoma | 2017 | xboxone |
| Taiho Shichau zo - You're Under Arrest | 2001 | ps1 |
| Taikou Risshiden III | 1999 | ps1 |