| Sakura - Setsu Gekka | 2003 | ps2 |
| Sakura Daejeon - Tteugeoun Yeoljeongeuro | 2004 | ps2 |
| Sakura Momoko no UkiUki Carnival | 2002 | gba |
| Sakura Note - Ima ni Tsunagaru Mirai | 2009 | nds |
| Sakura Sakura | 2018 | vita |
| Sakura Sakura - Haru Urara | 2010 | psp |
| Sakura Taisen | 1996 | saturn |
| Sakura Taisen - Atsuki Chishio ni | 2003 | ps2 |
| Sakura Taisen - Hanagumi Taisen Columns | 1997 | arcade, saturn |
| Sakura Taisen - Jouki Radio Show | 1997 | saturn |
| Sakura Taisen 3 - Paris wa Moeteiru ka | 2001 | dreamcast |
| Sakura Taisen 3 - Paris wa Moeteiru ka | 2005 | ps2 |
| Sakura Taisen GB - Geki Hanagumi Nyuutai! | 2000 | gbc |
| Sakura Taisen Monogatari - Mysterious Paris | 2004 | ps2 |
| Sakura Tsuushin | 1998 | saturn |
| Sakurasou no Pet na Kanojo | 2013 | psp, vita |
| Salad no Kuni no Tomato Hime | 1988 | nes |
| Salada no Kuni no Tomato Hime | | wii |
| Salaryman Kintarou - The Game | 2000 | ps1 |
| Saltsea Chronicles | 2023 | switch |
| Sam & Max - Season One | 2008 | wii |
| Sam & Max Beyond Time and Space | 2009 | wii, xbox360 |
| Sam & Max Beyond Time and Space Remastered | 2022 | ps4 |
| Sam & Max Beyond Time and Space Remastered | 2021 | switch, xboxone |
| Sam & Max Save the World Remastered | 2020 | ps4, switch, xboxone |
| Sam & Max: The Devil's Playhouse Remastered | 2024 | ps4, switch, xboxone |
| Sam Mallard - The Case of the Missing Swan | 2022 | gb |
| Samantha Swift and the Hidden Roses of Athena | 2010 | nds |
| Samantha Swift and the Hidden Roses of Athena | 2010 | nds |
| Samurai 7 | 2006 | ps2 |
| Samurai Dou 2 Portable | 2009 | psp |
| Samurai Dou Portable | 2008 | psp |
| Samurai Sword | 1988 | fds |
| Sandy's Circus Adventure | 1991 | cdi |
| Sandy's Circus Avontuur | 1992 | cdi |
| Sandy's Zirkus Abenteuer | 1992 | cdi |
| Sangoku Hime 4 - Tenka Ryouran - Tenmei no Koi Emaki | | vita |
| Sangoku Rensenki - Otome no Heihou! | 2011 | ps2 |
| Sangoku Rensenki - Otome no Heihou! | 2012 | psp |
| Sanma no Meitantei | 1987 | nes |
| Sarah - Keeper of the Unicorn | 2007 | nds |
| Satomi Hakkenden - Hachitama no Ki | 2014 | psp |
| Satsui no Kaisou - Soft House Renzoku Satsujin Jiken | 1988 | nes |
| Scandal | 2000 | ps2 |
| Scared Rider Xechs | 2010 | ps2 |
| Scared Rider Xechs - Stardust Lovers | 2011 | ps2 |
| Scared Rider Xechs Rev | 2015 | vita |
| Scarface - Money. Power. Respect | 2006 | psp |
| Scarlet - Nichijou no Kyoukaisen | 2008 | ps2 |
| Scarlett Mysteries: Cursed Child | 2019 | ps4 |
| Scheming Through the Zombie Apocalypse: The Beginning | 2019 | xboxone |
| School Days LxH | 2008 | ps2 |
| School Love! Koi to Kibou no Metronome | 2006 | ps2 |
| School Rumble - Anesan Jiken desu! | 2005 | psp |
| School Rumble - Neru Musume wa Sodatsu | 2005 | ps2 |
| School Rumble Nigakki - Kyoufu no Natsu Gasshuku! Youkan ni Yuurei Arawaru! Otakara o Megutte Makkou Shoubu!!! no Maki | 2007 | ps2 |
| School Wars | 2012 | psp |
| School Wars - Sotsugyou Sensen | 2013 | psp |
| Scooby-Doo | 2001 | gba |
| Scooby-Doo and the Cyber Chase | 2001 | gba |
| Scooby-Doo! - Classic Creep Capers | 2000 | gbc, n64 |
| Scooby-Doo! Qui Regarde Qui | 2006 | psp |
| Scotland Yard - Hunting Mister X | 2008 | nds |
| Scotland Yard Interactif | 1994 | cdi |
| Scotland Yard Interactive | 1994 | cdi |
| Scream Mr. Jack | 2021 | genesis |
| Screen | 2000 | ps1 |
| Sea Hunt ~ Scuba Diver | 1983 | a2600 |
| Sea Monsters - A Prehistoric Adventure | 2007 | wii |
| Sea of Solitude | 2019 | ps4, xboxone |
| Second Novel - Kanojo no Natsu, 15fun no Kioku | 2010 | psp |
| Second Samurai | 1994 | genesis |
| Secret Files - Tunguska | 2008 | nds, wii |
| Secret Files - Tunguska | 2016 | wiiu |
| Secret Files 2 - Puritas Cordis | 2009 | nds, wii |
| Secret Flirts - Make Everyone Fall For You! | 2010 | nds |
| Secret Game - Killer Queen | 2008 | ps2 |
| Secret Game - Killer Queen - Portable | 2010 | psp |
| Secret Mission | 1996 | cdi |
| The Secret Order: Return to the Buried Kingdom | 2020 | ps4 |
| The Secret Order: Shadow Breach | 2020 | ps4 |
| Secret Scout in the Temple of Demise | 1991 | nes |
| Secret Ties | 1992 | nes |
| Secret of Evangelion | 2008 | ps2 |
| The Secret of Monkey Island | 1993 | segacd |
| Secrets of the Titanic | 2012 | 3ds |
| Secrets of the Titanic 1912-2012 | 2012 | nds |
| Sega 3D Classics Collection | 2016 | 3ds |
| Segare Ijiri | 1999 | ps1 |
| Seikai no Monshou | 2000 | ps1 |
| Seikai no Senki | 2007 | ps2 |
| Seiken Psychocalibur - Majuu no Mori Densetsu | 1987 | fds |
| Seirei Gari | 1989 | nes |
| Seishun Hajimemashita! | 2013 | psp |
| Seitokai no Ichizon - DS Suru Seitokai | 2010 | nds |
| Seitokai no Ichizon Lv. 2 Portable | 2013 | psp |
| Sekai no Subete - Two of Us | 2006 | ps2 |
| Sekirei - Mirai kara no Okurimono | 2009 | ps2 |
| Sekiryuuou | 1989 | nes |
| Sen no Hatou, Tsukisome no Kouki | | vita |