| Return to Monkey Island | 2022 | switch |
| Return to Zork | 1995 | pcfx, ps1, saturn |
| Revive... - Sosei | 1999 | dreamcast |
| Rewrite | 2014 | ps3, ps4, psp, vita |
| Rewrite Harvest Festa! | 2017 | vita |
| Rhino Rumble | 2002 | gbc |
| Rhythm Kaitou R - Koutei Napoleon no Isan | 2013 | 3ds |
| Rift Keeper | 2019 | xboxone |
| Rim Runners | 2005 | ps2 |
| Rime | 2017 | ps4, switch, xboxone |
| Ring Infinity | 2000 | ws |
| Ring of Sias | 1996 | ps1 |
| Ripple Island | 1988 | nes |
| Ripuru no Tamago - Apprentice Magician | 2003 | ps2 |
| Risa no Yousei Densetsu | 1988 | fds |
| Rise of the Dragon | 1993 | segacd |
| Rise of the Dragon - A Blade Hunter Mystery | 1992 | segacd |
| Riven - A Sequencia de Myst | 1998 | saturn |
| Riven - The Sequel to Myst | 1997 | ps1, saturn |
| The Rivers of Alice - Extended Version | 2015 | wiiu |
| Ro-Kyu-Bu! | 2011 | psp |
| Ro-Kyu-Bu! Himitsu no Otoshimono | 2013 | psp |
| Ro-Kyu-Bu! Naisho no Shutter Chance | 2014 | vita |
| Road 96 | 2022 | ps4 |
| Robby's Day Out | 2020 | gb |
| Robin Hood - The Return of Richard | 2010 | wii |
| Robotics;Notes | 2012 | ps3, vita, xbox360 |
| Robotics;Notes Dash | 2019 | ps4, switch |
| Robotics;Notes Elite | 2019 | ps4 |
| Robotics;Notes Elite | 2019 | switch |
| Rockin' Kats | 1991 | arcade, nes |
| Rokudenashi Blues - Taiketsu! Tokyo Shitennou | 1994 | snes |
| Romancia | 1987 | nes |
| Romeo & Juliet | 2014 | psp |
| Romeo vs. Juliet | 2013 | psp |
| Roommate - Ryouko in Summer Vacation | 1997 | saturn |
| Roommate 3 - Ryouko Kaze no Kagayaku Asa ni | 1998 | saturn |
| Roommate Asami - Okusama wa Joshikousei | 2002 | ps2 |
| Roommate Novel - Satou Yuka | 2000 | dreamcast |
| Root Double - Before Crime - After Days | 2012 | xbox360 |
| Root Double - Before Crime - After Days - Xtend Edition | 2013 | ps3 |
| Root Double - Before Crime - After Days - Xtend Edition | 2014 | vita |
| Root Double - Before Crime - After Days - Xtend Edition | 2018 | vita |
| Root Film | 2020 | ps4, switch |
| Root Letter | 2016 | ps4, vita |
| Root Letter: Last Answer | 2018 | ps4, switch, vita |
| Rosario to Vampire - Tanabata no Miss Youkai Gakuen | 2008 | nds |
| Rosario to Vampire Capu 2 - Koi to Yume no Rhapsodia | 2009 | ps2 |
| A Rose in the Twilight | 2016 | vita |
| Roswell Conspiracies - Aliens, Myths & Legends | 2001 | gbc |
| Routes PE | 2007 | ps2 |
| Routes Portable | 2007 | psp |
| Rozen Maiden - Wechseln Sie Welt ab | 2014 | ps3, vita |
| Rudolph - The Red-Nosed Reindeer | 2010 | nds, wii |
| Rui wa Tomo o Yobu | 2013 | ps3, vita |
| Rui wa Tomo wo Yobu | | ps3 |
| Rule of Rose | 2006 | ps2 |
| Runaway - A Twist of Fate | 2010 | nds |
| Runaway - The Dream of the Turtle | 2007 | nds, wii |
| Rune Princess | 2005 | ps2 |
| Ruriiro no Yuki | 1998 | saturn |
| Rurouni Kenshin - Meiji Kenkaku Romantan - Enjou! Kyoto Rinne | 2006 | ps2 |
| Ryan Veeder's Mud Warriors | 2021 | gbc |
| Ryan's Rescue Squad | 2022 | switch |
| Ryouko no Oshaberi Room | 1999 | saturn |
| Ryu-Koku | 2006 | ps2 |
| Ryu-Koku | 2011 | psp |
| The Ryuo's Work Is Never Done! | 2020 | ps4, switch |
| Ryuuteki Gosennen - Dragons of China | 1997 | saturn |
| S.Y.K - Renshouden | 2010 | ps2 |
| S.Y.K - Shinsetsu Saiyuuki | 2009 | ps2 |
| S.Y.K - Shinsetsu Saiyuuki Portable | 2010 | psp |
| S.Y.K Renshouden Portable | 2011 | psp |
| SA7 - Silent Ability Seven | 2016 | vita |
| SM Choukyoushi Hitomi - Bangai Hen | 1995 | snes |
| SM Choukyoushi Hitomi - Bangai Hen 2 - Maki no Love Love Panic | 1997 | snes |
| SM Choukyoushi Hitomi Vol. 1 | 1994 | snes |
| SM Choukyoushi Hitomi Vol. 2 | 1997 | snes |
| SM Choukyoushi Hitomi Vol. 2 Remix | 1994 | snes |
| SOS | 1994 | snes |
| Sacred Line Genesis | 2013 | genesis |
| Sacred Line II | 2022 | genesis |
| Sacred Line Zero | | genesis |
| Sacred Meat | 2023 | gb |
| Sadakichi Seven - Hideyoshi no Ougon | 1988 | pcengine |
| Safari Adventures - Africa | 2009 | nds |
| Sagebrush | 2019 | ps4, xboxone |
| Saibanin Suiri Game - Yuuzai x Muzai | 2009 | nds |
| Saihate no Ima Portable | 2012 | psp |
| Saint Beast - Rasen no Shou | 2007 | ps2 |
| Saint Kotar | 2022 | switch |
| Saint Seiya - Ougon Densetsu Kanketsu Hen | 1988 | nes |
| Saint Sword | 1991 | genesis |
| Saints Row - Undercover | | psp |
| Saishuu Densha | 1998 | ps1, ps2 |
| Saishuu Heiki Kanojo | 2003 | ps2 |
| Saishuu Shiken Kujira - Alive | 2007 | ps2 |
| Saiyuuki Reload | 2004 | ps2 |
| Sakaagari Hurricane Portable | 2011 | psp |
| Saki - Zenkoku-hen Plus | 2016 | vita |