| Sengo Muramasa DX - Guren no Kettou | | vita |
| Sengoku Hime - Senran ni Mau Otometachi | 2009 | psp |
| Sengoku Hime 2 - Senran no Yo, Gun'yuu Arashi no Gotoku | | xbox360 |
| Sengoku Hime 3 - Tenka o Kirisaku Hikari to Kage | 2012 | ps3, psp, vita |
| Sengoku Hime 4 - Souha Hyakkei Hana Mamoru Chikai | | vita |
| Sengoku Hime 4 - Souhahyakkei, Hana Mamoru Chikai | 2014 | ps3 |
| Sengoku-hime 5 - Senka Tatsu Haou no Keifu | 2015 | ps3 |
| Senjou no Waltz | | vita |
| Senkai Tsuuroku Seishi - TV Animation Senkaiden Houshin Engi yori | 2001 | ps1 |
| Senri no Kifu: Gendai Shougi Mystery | 2020 | ps4, switch |
| Senseless City - Space Jesus | 2023 | nes |
| Sentient | 1997 | ps1 |
| Sentient - Explore the Infinite | 1997 | ps1 |
| Sentimental Graffiti | 2001 | ps1 |
| Sentimental Graffiti - Yakusoku | 2001 | ps1 |
| Sentimental Graffiti 2 | 2000 | dreamcast |
| Sentimental Graffiti 2 - Third Window | 2000 | dreamcast |
| Sentimental Prelude | 2005 | ps2 |
| Separate Hearts | 2006 | ps2 |
| Septentrion | 1993 | snes |
| Sesame Street - Elmo's Musical Monsterpiece | 2012 | nds |
| Sesame Street - Once Upon a Monster | 2011 | xbox360 |
| Sesame Street Counting Cafe | 1994 | genesis |
| Seven Days - Anata to Sugosu Nanokakan | 2018 | vita |
| Sex | 1994 | 3do |
| The Sexy Brutale | 2017 | ps4, switch, xboxone |
| Shadoan | 1996 | cdi |
| Shadow and Shadow | 2002 | ps1 |
| Shadow of Destiny | 2001 | ps2, psp, xbox |
| Shadow of Memories | 2010 | psp |
| Shadowgate | 1989 | nes |
| Shadowgate | 2019 | ps4, switch, xboxone |
| Shadowgate Classic | 1999 | gbc |
| Shadowgate Return | 1999 | gbc |
| Shakugan no Shana | 2006 | ps2 |
| Shakugan no Shana DS | 2007 | nds |
| Shamu's Deep Sea Adventures | 2005 | gba, nds |
| Shaolin's Road | 1995 | cdi |
| Shape of the World | 2018 | ps4, xboxone |
| The Shapeshifter | 2022 | gb |
| Sharin no Kuni, Himawari no Shoujo | 2012 | psp |
| Shaun the Sheep | 2008 | nds |
| She Dreams Elsewhere | | switch, xboxone |
| She and the Light Bearer | 2019 | switch |
| She'sn | 1998 | saturn |
| Shelly Club | 2001 | gbc |
| Shenmue - Isshou Yokosuka | 2000 | dreamcast |
| Shentan Kenan | 1991 | nes |
| Sherlock Holmes - Consulting Detective | 1991 | pcengine, segacd |
| Sherlock Holmes - Consulting Detective - Vol. II | 1993 | pcengine, segacd |
| Sherlock Holmes - Crimes & Punishments | 2014 | ps3, ps4, switch, xbox360, xboxone |
| Sherlock Holmes DS - The Mystery of the Mummy | 2009 | nds |
| Sherlock Holmes DS and the Mystery of Osborne House | 2010 | nds |
| Sherlock Holmes Puzzle City | 2014 | 3ds |
| Sherlock Holmes Versus Jack the Ripper | | xbox360 |
| Sherlock Holmes: The Awakened | 2023 | ps4, switch, xboxone |
| Sherlock Holmes: The Devil's Daughter | 2016 | ps4, switch, xboxone |
| Shi no Homura | 2008 | ps2 |
| Shiawase Usagi - Nureta Bishoujo - Hajimete Nanoni | 1995 | pcengine |
| Shichisei Toushin Guyferd - Crown Kaimetsu Sakusen | 1998 | saturn |
| Shiei no Sona-Nyl Refrain - What a Beautiful Memories | 2014 | psp, xbox360 |
| Shijuu Hachi | 2007 | ps2 |
| Shikaku Tantei Sora no Sekai - Thousand Dreams | 2007 | ps2 |
| Shikigami no Shiro - Nanayozuki Gensoukyoku | 2005 | ps2 |
| Shin Hayarigami | 2014 | ps3, vita |
| Shin Hayarigami 2 | 2016 | ps3, vita |
| Shin Hisui no Shizuku - Hiiro no Kakera 2 | 2009 | ps2 |
| Shin Hisui no Shizuku - Hiiro no Kakera 2 Portable | 2010 | psp |
| Shin Kamaitachi no Yoru - 11-ninme no Suspect | 2011 | ps3 |
| Shin Kisekae Monogatari | 2003 | gba |
| Shin Koihime Musou - Otome Ryouran Sangokushi Engi | 2011 | ps2 |
| Shin Koihime Musou Ryouran Gohen | 2011 | psp |
| Shin Koihime Musou Ryouran Shokuhen | 2010 | psp |
| Shin Lucky Star Moe Drill - Tabidachi | 2007 | nds |
| Shin Onryou Senki | 1995 | pcengine |
| Shin Seiki Evangelion | 1996 | saturn |
| Shin Seiki Evangelion - 2nd Impression | 1997 | saturn |
| Shin Seiki Evangelion - Koutetsu no Girlfriend | 1998 | ps1 |
| Shin Seiki Evangelion - Koutetsu no Girlfriend 2nd | 2005 | ps2 |
| Shin Seiki Evangelion - Koutetsu no Girlfriend 2nd Portable | 2009 | psp |
| Shin Seiki Evangelion - Koutetsu no Girlfriend Tokubetsu-hen | 2006 | ps2 |
| Shin Seiki Evangelion - Koutetsu no Girlfriend Tokubetsu-hen | 2009 | psp |
| Shin Seiki Evangelion - Typing E Keikaku | 2001 | dreamcast |
| Shin Seiki Evangelion 2 - Evangelions | 2003 | ps2 |
| Shin Star Trek - Ooinaru Isan IFD no Nazo o Oe | 1995 | snes |
| Shine - Kotoba o Tsumui de | 2002 | ps2 |
| Shingeki no Kyojin - Shichi-Kara no Dasshutsu | 2017 | 3ds |
| Shinigami Kagyou - Kaidan Romance | 2013 | psp |
| Shinigami to Shoujo | 2011 | psp, vita |
| Shinkyoku Soukai Polyphonica | 2007 | ps2 |
| Shinkyoku Soukai Polyphonica - 0-4 wa Full Pack | | psp |
| Shinkyoku Soukai Polyphonica - 0~4-wa Full Pack | 2008 | ps2 |
| Shinkyoku Soukai Polyphonica - 3 & 4-wa Kanketsu-hen | 2007 | ps2 |
| Shinkyoku Soukai Polyphonica - After School | 2010 | ps2 |
| Shinkyoku Soukai Polyphonica - After School | | psp |
| Shinkyoku Soukai Polyphonica - The Black - Episode 1 & 2 CS Edition | 2009 | ps2 |
| Shinobido - Tales of the Ninja | 2007 | psp |
| Shinpi no Sekai El-Hazard - El-Hazard - The Magnificent World for Sega Saturn | 1996 | saturn |
| Shinreigari - Ghost Hound DS | 2008 | nds |
| The Shinri Game | 1994 | gb |