| Sol Divide | 1998 | ps1, ps2, saturn |
| Sol Divide | 2022 | ps4 |
| Sol Divide: Sword Of Darkness | 1997 | arcade |
| Sol-Deace | 1992 | genesis |
| Sol-Feace | 1991 | segacd |
| Solar Assault | 1997 | arcade |
| Solar Assault Revised | 1997 | arcade |
| Solar Conqueror | 1983 | astrocade |
| Solar Crusade | 1999 | cdi |
| Solar Eclipse | 1995 | ps1, saturn |
| Solar Fight | 1979 | arcade |
| Solar Jetman - Hunt for the Golden Warpship | 1990 | nes |
| Solar Quest | 1981 | arcade, vectrex |
| Solaris | 2016 | nes |
| Soldier Blade | 1992 | pcengine, wiiu |
| Soldier Blade | 2007 | wii |
| Soldier Blade - Special Version | 1992 | pcengine |
| Soldier Girl Amazon | 1986 | arcade |
| Soldier of Fortune | 2001 | dreamcast |
| Soldier of Fortune - Gold Edition | 2001 | ps2 |
| Soldier of Fortune - Payback | 2007 | ps3, xbox360 |
| Soldier of Fortune II - Double Helix | 2003 | xbox |
| Soldiers of Fortune | 1993 | genesis, snes |
| Soldner-X - Himmelssturmer | 2008 | ps3 |
| Soldner-X 2 - Final Prototype | 2010 | ps3, ps4, vita |
| Solite Spirits | 1999 | arcade |
| Solvalou | 1991 | arcade, wii |
| Somer Assault | 1992 | pcengine |
| Son Son | 1984 | arcade |
| Son of Phoenix | 1985 | arcade |
| Son of Scoregasm | 2017 | vita |
| Sonic Boom | 1987 | arcade |
| Sonic Wings Limited | 1996 | arcade |
| Sonic Wings Reunion | 2025 | switch |
| Sonic Wings Special | 1996 | ps1, saturn |
| Sorcer Striker | 1993 | arcade, ps4 |
| Sorcer Striker | 1993 | arcade |
| The Sorcerer's Apprentice | 2010 | nds |
| Soreyuke! Burunyan-Man Portable - Torimodose! Ai to Seigi to Kibou no Tsunyakan | 2012 | psp |
| Soukyugurentai / Terra Diver | 1996 | arcade |
| Soukyuu Gurentai | 1997 | saturn |
| Soukyuu Gurentai - Otokuyou | 1997 | saturn |
| SoulStar | 1994 | segacd |
| Soulstar X | 1995 | 32x |
| South Park | 1998 | n64, ps1 |
| Soviet Union 2010 | 2010 | vb |
| Soviet Union 2011 | 2011 | vb |
| Space Armor | 1984 | sg1000 |
| Space Attack | 1979 | arcade |
| Space Attack II | 1980 | arcade |
| Space Battle | 1980 | arcade |
| Space Battle Ship Gomorrah | 1990 | arcade |
| Space Beam | 1979 | arcade |
| Space Bird | 1980 | arcade |
| Space Bomber | 1998 | arcade |
| Space Bugger | 1981 | arcade |
| Space Combat | 1979 | arcade |
| Space Cruiser | 1981 | arcade |
| Space Cyclone | 1980 | arcade |
| Space Demon | 1980 | arcade |
| Space Dragon | 1980 | arcade |
| Space Duel | 2007 | a7800 |
| Space Duel | 1980 | arcade |
| Space Dungeon | 1981 | arcade |
| Space Echo | 1980 | arcade |
| Space Empire | 1980 | arcade |
| Space Encounters | 1980 | arcade |
| Space Fever | 1979 | arcade |
| Space Fighter | 1992 | svision |
| Space Fighter Mark II | 1979 | arcade |
| Space Firebird | 1980 | arcade |
| Space Force | 1980 | arcade |
| Space Fortress | 1981 | astrocade |
| Space Fortress | 1981 | arcade |
| Space Guerrilla | 1979 | arcade |
| Space Gun | 1990 | arcade |
| Space Harrier | 1986 | 32x, sms |
| Space Harrier | 1991 | gg |
| Space Harrier | 1989 | nes |
| Space Harrier | 1988 | pcengine |
| Space Harrier | 1985 | arcade |
| Space Harrier 3-D | 1988 | sms |
| Space Harrier 3D | 1988 | sms |
| Space Harrier II | 1988 | genesis |
| Space Harrier II | 2006 | wii |
| Space Harrier II | 1988 | arcade |
| Space Hero | 1992 | genesis |
| Space Hulk - Vengeance of the Blood Angels | 1995 | 3do, ps1, saturn |
| Space Hulk: Deathwing | 2018 | ps4 |
| Space Intruder | 1980 | arcade |
| Space Invaders | 1980 | a2600 |
| Space Invaders | 1978 | a5200, arcade, gb, nes, ps1, saturn, sg1000, snes, ws |
| Space Invaders | 2008 | a7800 |
| Space Invaders | 1979 | astrocade |
| Space Invaders | 2002 | gba |
| Space Invaders | 1999 | gbc, n64, ps1 |
| Space Invaders | 2022 | genesis |
| Space Invaders '91 | 1991 | genesis |
| Space Invaders '95: The Attack Of Lunar Loonies | 1995 | arcade |
| Space Invaders - Fukkatsu no Hi | 1990 | pcengine, wii |