| Splatoon 3 | 2022 | switch |
| Splendor Blast | 1985 | arcade |
| Splendor Blast II | 1985 | arcade |
| Splitgate | 2021 | ps4 |
| Splitgate 2 | 2025 | ps4 |
| Sports Shooting USA | 2003 | arcade |
| Spriggan Mark 2 - Re Terraform Project | 1992 | pcengine |
| Spriggan Powered | 1996 | snes |
| Spy Games - Elevator Mission | 2007 | wii |
| Spy Hunter II | 1987 | arcade |
| Sqoon | 1986 | nes |
| Squadron 51 | | ps4 |
| Squadron 51 | 2022 | xboxone |
| Square Heroes | 2016 | ps4 |
| Stagger I | 1998 | arcade |
| Stalactites | 2026 | sms |
| Star Battle | 1979 | astrocade |
| Star Blade | 2009 | wii |
| Star Blazer | 1983 | arcade |
| Star Castle | 1980 | arcade, vectrex |
| Star Control II | 1994 | 3do |
| Star Control II - The Ur-Quan Masters | | 3do |
| Star Cruiser | 1977 | arcade |
| Star Fighter | 1979 | arcade |
| Star Fire | | col |
| Star Fire | 1979 | arcade |
| Star Fire 2 | 1979 | arcade |
| Star Force | 1984 | arcade, nes, sg1000 |
| Star Force | 2009 | wii |
| Star Fox | 1993 | snes |
| Star Fox - Assault | 2005 | gc |
| Star Fox 2 | 1995 | snes |
| Star Fox 64 | 2016 | wiiu |
| Star Fox Command | 2006 | nds |
| Star Fox Command | 2015 | wiiu |
| Star Fox Zero | 2016 | wiiu |
| Star Gate | 1987 | nes |
| Star Ghost | 2016 | wiiu |
| Star Guards | 1987 | arcade |
| Star Jacker | 1983 | arcade, sg1000 |
| Star Luster | 1985 | nes, wiiu |
| Star Parodier | 1992 | pcengine |
| Star Parodier | | wii |
| Star Ship | 1982 | vectrex |
| Star Soldier | 1986 | nes |
| Star Soldier | 2005 | psp, wii |
| Star Soldier | | sg1000 |
| Star Soldier - Vanishing Earth | 1998 | n64 |
| Star Soldier R | 2008 | wii |
| Star Soldier: Vanishing Earth | 1998 | arcade |
| Star Strike Delta | 2012 | vita |
| Star Strike HD | 2007 | ps3 |
| Star Strike Portable | 2008 | psp |
| Star Trek | | gbc |
| Star Trek | 2013 | ps3, xbox360 |
| Star Trek - Encounters | 2006 | ps2 |
| Star Trek - The Motion Picture | 1982 | vectrex |
| Star Trek - Voyager - Elite Force | 2001 | ps2 |
| Star Trek D.A.C | 2009 | ps3, xbox360 |
| Star Trek Generations - Beyond the Nexus | 1994 | gg |
| Star Trek: Voyager | 2002 | arcade |
| Star Versus | 2015 | nes |
| Star Voyager | 1987 | nes |
| Star Warrior | 1980 | arcade |
| Star Wars | 1983 | arcade |
| Star Wars | 1979 | arcade |
| Star Wars | 1994 | arcade |
| Star Wars - Battlefront - Elite Squadron | 2009 | nds, psp |
| Star Wars - Battlefront - Renegade Squadron | 2007 | psp |
| Star Wars - Battlefront II | 2005 | ps2, psp, xbox |
| Star Wars - Dark Forces | 1996 | ps1 |
| Star Wars - Flight of the Falcon | 2003 | gba |
| Star Wars - Jedi Knight - Jedi Academy | 2003 | ps4, switch, xbox |
| Star Wars - Jedi Knight II - Jedi Outcast | 2002 | gc, xbox |
| Star Wars - Rebel Assault | 1994 | 3do, segacd |
| Star Wars - Republic Commando | 2005 | ps4, switch, xbox |
| Star Wars - Return of the Jedi - Ewok Adventure | 1983 | a2600 |
| Star Wars - Rogue Squadron | 1998 | n64 |
| Star Wars - Rogue Squadron II - Rogue Leader | 2001 | gc |
| Star Wars - Rogue Squadron III | 2003 | gc |
| Star Wars - Rogue Squadron III - Rebel Strike | 2003 | gc |
| Star Wars - Shadows of the Empire | 1996 | n64 |
| Star Wars - Starfighter Special Edition | 2001 | xbox |
| Star Wars - The Force Unleashed - Ultimate Sith Edition | 2009 | ps3, xbox360 |
| Star Wars Arcade | 1994 | 32x |
| Star Wars Battlefront | 2015 | ps4, xboxone |
| Star Wars Battlefront II | 2017 | ps4, xboxone |
| Star Wars Episode I - Battle for Naboo | 2000 | n64 |
| Star Wars Jedi Knight II: Jedi Outcast | 2019 | ps4, switch |
| Star Wars Trilogy Arcade | 1998 | arcade |
| Star Wars: Battlefront Classic Collection | 2024 | ps4, switch |
| Star X | 2002 | gba |
| StarHawk | 1993 | gb |
| Starblade | 1991 | 3do, arcade, segacd |
| Starblade Alpha | 1995 | ps1 |
| Starborders | 1997 | ps1 |
| Stardust Galaxy Warriors: Stellar Climax | 2016 | ps4, xboxone |
| Stardust Galaxy Warriors: Stellar Climax | 2020 | ps4 |
| Starfield Battle 2 | 2010 | xbox360 |
| Starfighter | | arcade |