| Stargate | 1981 | a2600, arcade, nes |
| Stargate | 1984 | a2600, a5200 |
| Stargunner | 1982 | a2600 |
| Starhawk | 2012 | ps3 |
| Starhawk | 1979 | arcade, vectrex |
| Starseed | 2024 | gbc |
| Starseed 2 | 2024 | gbc |
| Starship 1 | 1977 | arcade |
| Starship Hector | 1990 | nes |
| Starwing | 1993 | snes |
| Starwing - Competition | 1993 | snes |
| State of Anarchy: Master of Mayhem | 2018 | xboxone |
| Station 7 | 1999 | ps1 |
| Station 9 | 1999 | ps1 |
| Stealth Force - The War on Terror | 2005 | ps2 |
| Stealth Force 2 | 2008 | ps2 |
| Steam-Heart's | 1998 | saturn |
| Steel Diver | 2011 | 3ds |
| Steel Diver - Sub Wars | 2014 | 3ds |
| Steel Diver - Update 1.1 | 2014 | 3ds |
| Steel Dragon EX | 2003 | ps2 |
| Steel Empire | 2015 | 3ds |
| Steel Empire | 2004 | gba |
| Steel Empire | 1992 | genesis |
| Steel Gunner | 1990 | arcade |
| Steel Gunner 2 | 1991 | arcade |
| Steel Machine | 1993 | cdi |
| Steel Moons | 2023 | nes |
| Steel Rain X | 2016 | xboxone |
| Stellar Assault | 1995 | 32x |
| Stellar Assault SS | 1998 | saturn |
| Stellar Castle | 1980 | arcade |
| Stellatum | 2019 | ps4, xboxone |
| Steraranger | 1980 | arcade |
| Steredenn | 2016 | ps3, ps4, xboxone |
| Stinger | 2023 | lynx |
| Stinger | 1987 | nes |
| Stinger | 2015 | wiiu |
| Stinger | 1983 | arcade |
| Stoneage | 1991 | arcade |
| Stop Stress - A Day of Fury | 2009 | wii |
| Storm Blade | 1996 | arcade |
| Storming Party / Riku Kai Kuu Saizensen | 1986 | arcade |
| Strafe | 2017 | ps4 |
| Strafe Bomb | 1981 | arcade |
| Strahlen der Teufelsvogel | 1982 | a2600 |
| Straimium Immortaly | 2019 | ps4 |
| Strange Brigade | 2018 | ps4, switch, xboxone |
| Strania - The Stella Machina | 2011 | xbox360 |
| Strategy X | 1981 | arcade |
| Stratovox | 1980 | arcade |
| Street Drivin' | 1993 | arcade |
| Street Fight | 1986 | arcade |
| Street Heat | 1985 | arcade |
| Strike Fighter | 1991 | arcade, segacd |
| Strike Force | 1991 | arcade |
| Strike Force Hydra | 2003 | gba |
| Strike Gunner S.T.G | 1991 | arcade, snes |
| Strike Suit Zero: Director's Cut | 2014 | xboxone |
| Strike Vector EX | 2016 | ps4 |
| Strike Witches - Hakugin no Tsubasa | 2012 | psp |
| Strike Witches - Hakugin no Tsubasa | 2010 | xbox360 |
| Strike Wolf | 1992 | nes |
| Strikers 1945 | 1995 | arcade, ps1, saturn |
| Strikers 1945 | 2022 | ps4 |
| Strikers 1945 II | 2022 | ps4 |
| Strikers 1945 II | 1998 | saturn |
| Strikers 1945 II | 2018 | switch |
| Strikers 1945 III | 2022 | ps4 |
| Strikers 1945 III / Strikers 1999 | 1999 | arcade |
| Strikers 1945 Plus | 1999 | arcade, neogeo |
| Strikers 1945 Plus | 2009 | psp |
| Strikers 1945 Plus Portable | 2009 | psp |
| Stronghold | 1983 | a2600 |
| Stunt Air | 1983 | arcade |
| SturmFront - The Mutant War - Farewell Edition | 2021 | vita |
| Sturmwind | 2013 | dreamcast |
| Sturmwind Ex | 2019 | xboxone |
| Sub Hunter | 1977 | arcade |
| Sub-Scan | 1983 | a2600 |
| Sublevel Zero Redux | 2017 | ps4, xboxone |
| Submarine | 1985 | arcade |
| Submarine Attack | 2025 | genesis |
| Submarine Canyon Bomber vs Marine Aliens | 2017 | genesis |
| Subroc | 1983 | col |
| Subroc-3D | 1982 | arcade |
| Subs | 1977 | arcade |
| The Suffering - Ties That Bind | 2005 | ps2, xbox |
| The Sum of All Fears | 2002 | gba, gc, ps2 |
| Summer Carnival '92 - Alzadick | 1992 | pcengine |
| Summer Carnival '92 - Recca | 1992 | nes |
| Summer Carnival '93 - NEXZR Special | 1993 | pcengine |
| Sunset Riders | 1991 | arcade, genesis, snes |
| Sunset Riders 2 | 1991 | arcade |
| Super Air Zonk - Rockabilly-Paradise | 1993 | pcengine |
| Super Air Zonk - Rockabilly-Paradise | 2007 | wii |
| Super Aleste | 1992 | snes |
| Super Animal Royale | 2021 | switch |
| Super Astro Fighter | 1981 | arcade |
| Super B-Daman - Battle Phoenix 64 | 1998 | n64 |