| Silver Eagle | 1993 | nes |
| Silver Millennium | 1995 | arcade |
| Silver Surfer | 1990 | nes |
| Simple 1500 Series Vol. 24 - The Gun Shooting | 1999 | ps1 |
| Simple 1500 Series Vol. 35 - The Shooting | 2000 | ps1 |
| Simple 1500 Series Vol. 63 - The Gun Shooting 2 | 2001 | ps1 |
| Simple 2000 Series Ultimate Vol. 23 - Project Minerva Professional | 2005 | ps2 |
| Simple 2000 Series Vol. 105 - The Maid-fuku to Kikanjuu | 2006 | ps2 |
| Simple 2000 Series Vol. 119 - The Survival Game 2 | 2007 | ps2 |
| Simple 2000 Series Vol. 120 - The Saigo no Nihonhei - Utsukushiki Kokudo Dakkan Sakusen | 2007 | ps2 |
| Simple 2000 Series Vol. 31 - The Chikyuu Boueigun | 2003 | ps2 |
| Simple 2000 Series Vol. 50 - The Daibijin | 2004 | ps2 |
| Simple 2000 Series Vol. 53 - The Camera Kozou | 2004 | ps2 |
| Simple 2000 Series Vol. 81 - The Chikyuu Boueigun 2 | 2005 | ps2 |
| Simple Character 2000 Series Vol. 08 - Kagaku Ninja-tai Gatchaman - The Shooting | 2002 | ps1 |
| Simple DS Series Vol. 18 - The Soukou Kihei Gun Ground | 2007 | nds |
| Simple DS Series Vol. 21 - The Hohei - Butai de Shutsugeki! Senjou no Inu-tachi | 2007 | nds |
| Simple DS Series Vol. 32 - The Zombie Crisis | 2008 | nds |
| Simple Wii Series Vol. 4 - The Shooting Action | 2007 | wii |
| Simpson Junior | 2003 | arcade |
| Sin & Punishment | 2007 | wii |
| Sin & Punishment | 2015 | wiiu |
| Sin & Punishment - Star Successor | 2015 | wiiu |
| Sin Combat Choro Q | 2003 | ps2 |
| Sin and Punishment - Successor of the Skies | 2009 | wii |
| Sine Mora | 2012 | ps3, vita, xbox360 |
| Sine Mora EX | 2017 | ps4, switch, xboxone |
| Singularity | 2010 | ps3, xbox360 |
| Sinistar | 1984 | a2600 |
| Sinistar | 1982 | arcade |
| Sinistar | 2023 | arcade |
| Sinistron | 1991 | pcengine |
| Sirio II | | arcade |
| Sirius | 1990 | a7800 |
| Sisters Royale | 2020 | ps4 |
| Sisters Royale | 2018 | switch |
| Sisters Royale: Five Sisters Under Fire | 2020 | xboxone |
| Sixty Second Shooter Prime | 2014 | xboxone |
| Skeet Shot | 1991 | arcade |
| Skelagon | 1983 | arcade |
| Skeleton Krew | 1995 | cd32, genesis |
| Skies of Fury DX | 2018 | switch |
| Skull Fang | 1996 | arcade |
| Skull Fang - Kuhga Gaiden | 1996 | arcade |
| Skull Fang - Kuuga Gaiden | 1997 | saturn |
| Sky Adventure | 1989 | arcade |
| Sky Alert | 1992 | arcade |
| Sky Alien ~ Assault | 1983 | a2600 |
| Sky Army | 1982 | arcade |
| Sky Base | 1982 | arcade |
| Sky Bumper | 1982 | arcade |
| Sky Chuter | 1980 | arcade |
| Sky Destroyer | 1985 | arcade, nes |
| Sky Fighter | 1990 | sms |
| Sky Fire | 1979 | arcade |
| Sky Force Anniversary | 2016 | ps3, ps4, switch, vita, wiiu, xboxone |
| Sky Force Reloaded | 2017 | ps4, switch, xboxone |
| Sky Fox | 1987 | arcade |
| Sky Jaguar | 1984 | sms |
| Sky Kid | 1985 | arcade, nes |
| Sky Kid | 2008 | wii |
| Sky Kid Deluxe | 1986 | arcade |
| Sky Lancer | 1983 | arcade |
| Sky Love | 1979 | arcade |
| Sky Raider | 1978 | arcade |
| Sky Robo | 1989 | arcade |
| Sky Shark | 1989 | nes |
| Sky Shark | 1987 | arcade |
| Sky Skipper | 1981 | arcade |
| Sky Smasher | 1990 | arcade |
| Sky Soldiers | 1988 | arcade |
| Sky Target | 1995 | arcade |
| Sky Wolf | 1987 | arcade |
| SkyGunner | 2001 | ps2 |
| Skyhammer | 2000 | jaguar |
| Slamscape | 1996 | ps1 |
| Slap Fight | 1986 | arcade |
| SlashDash | 2015 | xboxone |
| Slither | 1982 | arcade |
| Sly Spy | 1989 | arcade |
| Smash T.V | 1990 | arcade, nes, snes |
| Snake Blasters | | snes |
| Sneaky Snake | 1983 | astrocade |
| Sniper - Ghost Warrior | 2010 | ps3, xbox360 |
| Sniper Assault | 2007 | ps2 |
| Sniper Elite | 2005 | ps2, ps3, wiiu, xbox, xbox360 |
| Sniper Elite - Game of the Year Edition | 2013 | ps3 |
| Sniper Elite 4 | 2017 | ps4, switch, xboxone |
| Sniper Elite 5 | 2022 | ps4 |
| Sniper Elite III | 2014 | ps3, ps4, xbox360, xboxone |
| Sniper Elite V2 Remastered | 2019 | ps4, switch, xboxone |
| Sniper Elite: Resistance | 2025 | ps4 |
| Sniper Ghost Warrior 3 | 2017 | ps4, xboxone |
| Sniper Ghost Warrior Contracts | 2019 | ps4, xboxone |
| Sniper Ghost Warrior Contracts 2 | 2021 | ps4, xboxone |
| Snipers - Invisible, Silent, Deadly | | ps3 |
| Snoopy Flying Ace | 2010 | xbox360 |
| Snowball Wars | 2007 | vb |
| Sogeki | 2001 | arcade |
| Sol Cresta | 2022 | ps4, switch |