| Serious Sam 4 | 2021 | ps4 |
| Serious Sam Advance | 2004 | gba |
| Serious Sam Collection | 2020 | ps4, switch, xboxone |
| Serious Sam HD | | xbox360 |
| Serious Sam HD - The First Encounter | 2010 | xbox360 |
| Serious Sam HD - The Second Encounter | 2010 | xbox360 |
| Serious Sam II | 2005 | xbox |
| Sewer Shark | 1992 | 3do, segacd |
| Sexy Invaders | 1990 | fds |
| Sexy Parodius | 1996 | arcade, ps1, saturn |
| Sgt. Helmet Training Day | 2013 | nes |
| Sgt. Rock - On the Frontline | 2000 | gbc |
| Shadow Complex Remastered | 2016 | xboxone |
| Shadow Ops - Red Mercury | 2004 | xbox |
| Shadow Tower | 1998 | ps1 |
| Shadow Warrior | 2014 | ps4, xboxone |
| Shadow Warrior 2 | 2017 | ps4, xboxone |
| Shadow Warrior 3 | 2022 | ps4, xboxone |
| Shadow of Ganymede | 2005 | ps2 |
| Shadow the Hedgehog | 2013 | ps3 |
| Shadowrun | 2007 | xbox360 |
| Shadows of the Damned | 2011 | ps3, xbox360 |
| Shamus | 2000 | gbc |
| Shark | 1975 | arcade |
| Shark Attack | 1980 | arcade |
| Sharpshooter | 1998 | arcade |
| ShellShock - Nam '67 | 2004 | ps2, xbox |
| ShellShock 2 - Blood Trails | 2009 | ps3, xbox360 |
| Sheriff | 1979 | arcade |
| Shienryu | 1997 | arcade |
| Shienryuu | 1997 | saturn |
| Shikhondo: Soul Eater | 2018 | ps4 |
| Shikhondo: Soul Eater | 2018 | xboxone |
| Shikigami no Shiro | 2001 | arcade, ps2, xbox |
| Shikigami no Shiro - internal build | 2001 | arcade |
| Shikigami no Shiro II / The Castle of Shikigami II | 2003 | arcade |
| Shikigami no Shiro III | 2007 | xbox360 |
| Shikigami no Shiro III | 2006 | arcade |
| Shin Combat Choro Q | 2002 | ps2 |
| Shin Hikari Shinwa - Palutena no Kagami | 2013 | 3ds |
| Shin Jinrui - The New Type | 1987 | nes |
| Shinobi III | 1993 | arcade |
| Shippu Mahou Daisakusen | 1994 | arcade |
| Shippuu Mahou Daisakusen - Kingdom-Grandprix | 1996 | saturn |
| Shipwreckers! | 1997 | ps1 |
| Shmup Collection | | wiiu |
| ShmupSpeed | 2018 | nes |
| Shock Troopers | 1997 | arcade, neogeo |
| Shock Troopers | 2012 | wii |
| Shock Troopers - 2nd Squad | 1998 | neogeo |
| Shock Troopers - 2nd Squad | 2012 | wii |
| Shock Troopers - 2nd Squad | 1998 | arcade |
| Shock Wave - Operation JumpGate | 1994 | 3do |
| Shockman | 2007 | wii |
| The Shoot | 2010 | ps3 |
| Shoot Away II | 1996 | arcade |
| Shoot Out | 1985 | arcade |
| Shootanto - Evolutionary Mayhem | 2009 | wii |
| Shootanto - Kako Hen | 2009 | wii |
| Shooter | | snes |
| Shootin' Gallery | 1983 | a2600 |
| Shooting Arcade | 1989 | a2600 |
| Shooting Gallery | 1987 | sms |
| Shooting Gallery | 1984 | arcade |
| Shooting Love - Trizeal | 2006 | ps2 |
| Shooting Love 2007 | 2007 | arcade |
| Shooting Love. 10-shuunen - XIIZeal & DeltaZeal | 2009 | xbox360 |
| Shooting Love. 200X | 2009 | xbox360 |
| Shooting Master | 1985 | arcade |
| Shooting Range | 1989 | nes |
| Shooting Star | 1994 | arcade |
| Shooting Studio | 2011 | ps3 |
| Shootout at Old Tucson | 1994 | 3do, arcade |
| Shooty Space | 2016 | wiiu |
| Shred Nebula | 2008 | xbox360 |
| Shrike Avenger | 1986 | arcade |
| Shutshimi | 2016 | vita, wiiu |
| Shuttle Invader | 1979 | arcade |
| Shylax | 2023 | genesis |
| Sid the Spellbinder | 1982 | o2 |
| Side Arms - Hyper Dyne | 1986 | arcade |
| Sidewinder | 1989 | nes |
| Sidewinder | 1988 | arcade |
| Silent Assault | 1990 | nes |
| Silent Debuggers | 1991 | pcengine |
| Silent Debuggers | 2007 | wii |
| Silent Line - Armored Core | 2003 | ps2 |
| Silent Scope | 1999 | arcade, dreamcast, gba, ps2 |
| Silent Scope 2 - Dark Silhouette | 2001 | ps2 |
| Silent Scope 2 - Fatal Judgement | 2001 | ps2 |
| Silent Scope 2 - Innocent Sweeper | 2001 | ps2 |
| Silent Scope 2 : Dark Silhouette | 2000 | arcade |
| Silent Scope 2 : Fatal Judgement | 2000 | arcade |
| Silent Scope 2 : Innocent Sweeper | 2000 | arcade |
| Silent Scope 3 | 2002 | ps2 |
| Silent Scope EX | 2001 | arcade |
| Silent Scope Fortune Hunter | 2002 | arcade |
| Silk Worm | 1990 | nes |
| Silk Worm | 1988 | arcade |
| Silpheed | 1993 | segacd |