| Samurai Aces | 2022 | ps4 |
| Samurai Aces | 1993 | arcade |
| Samurai Aces II: Sengoku Blade | 2022 | ps4 |
| Samurai Aces III: Sengoku Cannon | 2022 | ps4 |
| Samurai Warriors - Katana | 2007 | wii |
| Sanctum 2 | 2013 | ps3, xbox360 |
| Sand Scorpion | 1992 | arcade |
| Santatlantean | 2014 | pcengine |
| Sarge | 1985 | arcade |
| Sasuke vs. Commander | 1980 | arcade |
| Satan of Saturn | 1981 | arcade |
| Satan's Hollow | 1981 | arcade |
| Satazius Next | 2020 | dreamcast |
| Satellite 7 | 1985 | sms |
| Satellite Attack | 1983 | g7400 |
| Satellite Attack | 1981 | o2 |
| Saturn | 1983 | arcade |
| Saturn: Space Fighter 3D | 1979 | arcade |
| Saucer Wars | 2019 | jaguarcd |
| Saurian Front | 1991 | arcade |
| Sauro | 1987 | arcade |
| Savage Bees | 1985 | arcade |
| Scar-Lead Salvation | 2025 | ps4 |
| Scarface - The World Is Yours | 2006 | ps2, wii, xbox |
| Scintillatron 4096 | 2018 | vita |
| Scion | 1984 | arcade |
| Scooter Shooter | 1985 | arcade |
| Score Rush Extended | 2016 | ps4 |
| Score Rush Extended | | xboxone |
| Scorpion | 1982 | arcade |
| Scourge - Outbreak | 2013 | ps3, xbox360 |
| Scrabble | 1981 | arcade |
| Scramble | 2016 | a7800 |
| Scramble | 2017 | nes |
| Scramble | 1981 | arcade, vectrex, xbox360 |
| Scramble Cobra | 1995 | 3do |
| Scramble Cobra - Premium Version | 1995 | 3do |
| Scramble Spirits | 1988 | arcade, sms |
| Screencheat | 2016 | ps4, xboxone |
| Screw Loose | 1983 | arcade |
| Scud - The Disposable Assassin | 1997 | saturn |
| Sea Battle | 1980 | arcade |
| Sea Fighter Poseidon | 1984 | arcade |
| Sea Hawk | 1983 | a2600 |
| Sea Invasion | 1981 | arcade |
| Sea Wolf | 1987 | arcade |
| Sea Wolf II | 1978 | arcade |
| Sea of Dreamland | 1992 | nes |
| SeaBlade | 2002 | xbox |
| Seahawk | 1982 | a2600 |
| Seaquest - International Edition | 1983 | a2600 |
| Search & Destroy | 2006 | ps2 |
| Secret Agent | 1989 | arcade |
| Secret Command | 1986 | sms |
| Secret Command | 2009 | wii |
| Secret Ponchos | 2014 | ps4 |
| Secret Service | 2008 | ps2 |
| Secret Service | 2008 | xbox360 |
| Section 8 | 2009 | ps3, xbox360 |
| Section 8 - Prejudice | 2011 | ps3, xbox360 |
| Section Z | 1985 | arcade |
| Section-Z | 1987 | fds, nes |
| Seek and Destroy | 1994 | cd32 |
| Seek and Destroy | 2002 | ps2 |
| Sega 3D Fukkoku Archives | 2014 | 3ds |
| Sega Ages - After Burner II | 1996 | saturn |
| Sega Ages - Fantasy Zone | 1997 | saturn |
| Sega Ages - Galaxy Force II | 1998 | saturn |
| Sega Ages - Space Harrier | 1996 | saturn |
| Sega Ages 2500 Series Vol. 20 - Space Harrier II - Space Harrier Complete Collection | 2005 | ps2 |
| Sega Ages 2500 Series Vol. 33 - Fantasy Zone Complete Collection | 2008 | ps2 |
| Sega Ages 2500 Series Vol. 9 - Gain Ground | 2004 | ps2 |
| Sega Clay Challenge | 2008 | arcade |
| Sega NetMerc | 1993 | arcade |
| Sega Ninja | 1985 | arcade |
| Sega Strike Fighter | 2000 | arcade |
| Sega-Galaga | 1983 | sg1000 |
| SegaSonic Cosmo Fighter | 1993 | arcade |
| Sei Senshi Amatelass | 1986 | arcade |
| Seicross | 1986 | nes |
| Seicross | | wii |
| Seirei Senshi Spriggan | 1991 | pcengine |
| Seireki 1999 - Pharaoh no Fukkatsu | 1996 | ps1, saturn |
| Seitai Heiki Expendable | 1999 | dreamcast |
| Sen Jing - Guardian Storm | 1998 | arcade |
| Sengeki Striker | 1997 | arcade |
| Sengoku Ace | 1993 | arcade |
| Sengoku Blade - Sengoku Ace Episode II | 1996 | saturn |
| Sengoku Blade: Sengoku Ace Episode II / Tengai | 1996 | arcade |
| Sengoku Cannon - Sengoku Ace Episode III | 2005 | psp |
| Sengoku no Jieitai | 1980 | arcade |
| Senjou no Ookami II | 1990 | arcade |
| Senjyo | 1983 | arcade |
| Senko no Ronde Special | 2006 | arcade |
| Seraph | 2016 | ps4 |
| Seraphim | | ps4 |
| Serious Sam | 2002 | xbox |
| Serious Sam - Double D XXL | 2013 | xbox360 |
| Serious Sam - Next Encounter | 2004 | gc, ps2 |
| Serious Sam 3 - BFE | 2012 | ps3, xbox360 |