| Dragon's Lair | 1984 | col |
| Dragon's Lair | 1991 | gb |
| Dragon's Lair | 2001 | gbc |
| Dragon's Lair | 2011 | psp |
| Dragon's Lair - The Legend | 1991 | gb |
| Dragon's Lair - The Legend | 2001 | gb |
| DragonHeart | 1996 | gb |
| Dragonology | 2009 | nds |
| Dramatical Murder Re-Code | 2014 | vita |
| Drastic Killer | 2008 | ps2 |
| Draugen | 2020 | ps4, xboxone |
| Draw a Stickman - Epic 2 | 2017 | ps4, wiiu, xboxone |
| Draw a Stickman: Epic | 2015 | xboxone |
| A Drawing's Journey | 2017 | wiiu |
| DreadOut 2 | 2024 | switch |
| Dream C Club - Complete Edipyon! | 2012 | ps3 |
| Dream Daddy: A Dad Dating Simulator | 2019 | switch |
| Dream Day - Wedding Destinations | 2004 | nds |
| DreamWorks How to Train Your Dragon 2 | 2014 | wiiu |
| DreamWorks Madagascar 3 - The Video Game | 2012 | ps3 |
| Dreamfall - The Longest Journey | 2006 | xbox |
| Dreamfall Chapters: The Longest Journey | 2017 | ps4, xboxone |
| Dreamwalker: Never Fall Asleep | 2019 | ps4, xboxone |
| Drihoo | 2002 | xbox |
| Driven Out | 2019 | xboxone |
| Drowning | 2019 | vita |
| Druid - Yami e no Tsuisekisha | 1998 | ps1 |
| Duck Souls+ | 2020 | vita |
| Duel Masters 2 - Kirifuda Shoubu Ver | 2004 | gba |
| Dull Grey | 2021 | vita |
| Dumbo's Flying Circus | 1983 | a2600 |
| Dunamis 15 | 2011 | ps3, psp, xbox360 |
| Dunamis15 | | psp |
| Dune | 1993 | segacd |
| Dungeon of the Endless | 2016 | xboxone |
| Dungeons of Dreadrock | 2022 | switch |
| Duo Comic - Bakuretsu Hunter | 1994 | pcengine |
| Durarara!! 3way Standoff | | psp |
| Durarara!! 3way Standoff -alley- V | 2014 | vita |
| Durarara!! Relay | 2015 | vita |
| Dying: 1983 | | ps4 |
| Dying: 1983 | | xboxone |
| Dynamic Chord Feat. Apple-Polisher V Edition | 2018 | vita |
| Dynamic Chord Feat. Liar-S V Edition | 2016 | vita |
| Dynamic Chord Feat. Reve Parfait V Edition | 2016 | vita |
| Dynamite Headdy | 2007 | wii |
| E School Life | 2020 | switch |
| E'ragon | 2006 | psp |
| E.T. - The Extra-Terrestrial | 2001 | gba |
| E.T. - The Extra-Terrestrial - Escape from Planet Earth | 2001 | gbc |
| EVE Rebirth Terror | 2016 | vita |
| EZ-Flash V | 2004 | nds |
| Earthworm Jim - Menace 2 the Galaxy | 1999 | gbc |
| East End x Yuri - Eexy Life | 1996 | ps1 |
| Eastshade | 2019 | ps4, xboxone |
| Ecco - The Tides of Time | 1994 | genesis, gg, segacd, sms |
| Ecco - The Tides of Time | 2007 | wii |
| Ecco Jr | 2007 | wii |
| Ecco the Dolphin | 1992 | genesis, gg, segacd, sms, wii, xbox360 |
| Ecco the Dolphin - Defender of the Future | 2000 | dreamcast, ps2 |
| Ecco the Dolphin II | 1994 | genesis, gg |
| Echo Night | 1998 | ps1 |
| Echo Night - Beyond | 2004 | ps2 |
| Echo Night 2 - Nemuri no Shihaisha | 1999 | ps1 |
| Echoes of the Fey: The Fox's Trail | 2017 | xboxone |
| Edel Blume | 2008 | ps2 |
| Edgar: Bokbok in Boulzac | 2020 | xboxone |
| Edna & Harvey: Harvey's New Eyes | 2019 | ps4, xboxone |
| Edna & Harvey: The Breakout | 2020 | ps4, xboxone |
| Edogawa Ranpo no Kaijin Nijuu Mensou DS | 2008 | nds |
| Egipto II - La Profecia de Heliopolis | 2001 | ps1 |
| Egypt 1156 A.C. - L'Enigma della Tomba Reale | 1999 | ps1 |
| Egypt 1156 B.C. - Tomb of the Pharaoh | 1999 | ps1 |
| Egypt II - The Heliopolis Prophecy | 2001 | ps1 |
| Egypte 1156 AV. J.-C. - L'Enigme de la Tombe Royale | 1999 | ps1 |
| Eien no Aselia - Kono Daichi no Hate de | 2005 | ps2 |
| Eikoku Tantei Mysteria | 2013 | psp |
| Eko Eko Azarak - Wizard of Darkness | 1995 | ps1 |
| El Profesor Layton y el Futuro Perdido | 2010 | nds |
| El Profesor Layton y el Legado de los Ashalanti | 2013 | 3ds |
| El Profesor Layton y la Caja de Pandora | 2009 | nds |
| El Profesor Layton y la Llamada del Espectro | 2011 | nds |
| El Profesor Layton y la Mascara de los Prodigios | 2012 | 3ds |
| The Eldritch Monarch | 2024 | genesis |
| Elea | 2018 | xboxone |
| Elebits - The Adventures of Kai and Zero | 2009 | nds |
| Electrocop | 1989 | lynx |
| Eledees - The Adventures of Kai and Zero | 2009 | nds |
| Elemix! | 2003 | gba |
| Elf Adventure | 1983 | a2600 |
| Elf o Karu Monotachi | 1997 | saturn |
| Elf o Karu Monotachi - Kanzenban | 1997 | ps1 |
| Elf o Karu Monotachi II | 1998 | ps1, saturn |
| Eliza | 2019 | switch |
| Elkrone no Atelier - Dear for Otomate | 2012 | psp |
| Ellen: The Game | 2019 | xboxone |
| Elysion - Eien no Sanctuary | 2002 | dreamcast, ps2 |
| Embracelet | 2020 | switch |
| Emily Archer - The Curse of King Tut's Tomb | 2004 | nds |
| Emily the Strange - Strangerous | 2011 | nds |