| Dave the Diver | 2023 | switch |
| Day Dreamin' Davey | 1992 | nes |
| Day of the Tentacle Remastered | 2016 | vita |
| Day of the Tentacle: Remastered Edition | 2016 | ps4 |
| Days of Memories | 2007 | nds |
| Days of Memories 2 | 2008 | nds |
| Days of Memories 3 | 2009 | nds |
| De-Ja | 1996 | pcengine |
| Dead End - Orchestral Manoeuvres in the Dead End | 2011 | psp |
| Dead Head Fred | 2007 | psp |
| Dead Synchronicity: Tomorrow Comes Today | 2015 | ps4 |
| Dead Synchronicity: Tomorrow Comes Today | 2017 | switch |
| Dead Zone | 1986 | fds |
| Dead of the Brain 1&2 | 1999 | pcengine |
| Deadeus | 2022 | gb |
| Dear Boys - Fast Break! | 2003 | ps2 |
| Dear Daniel no Sweet Adventure - Kitty-chan o Sagashite | 2000 | gbc |
| Dear Esther | 2016 | ps4 |
| Dear Esther: Landmark Edition | 2016 | xboxone |
| Dear Girl - Stories - Hibiki - Hibiki Tokkun Daisakusen! | 2009 | nds |
| Dear My Friend - Love Like Powdery Snow | 2005 | ps2 |
| Dear me, I was... | 2026 | switch |
| Deardrops Distortion | 2011 | psp |
| Death Come True | 2020 | ps4, switch |
| Death Connection | 2009 | ps2 |
| Death Connection Portable | 2011 | psp |
| Deemo: Reborn | 2020 | switch |
| Deep Forest | 2020 | gb |
| Defcon 5 - Peace Has a Price | 1995 | ps1, saturn |
| Defunct | 2017 | switch, xboxone |
| Deiland | 2018 | ps4 |
| Deja Vu | 1990 | nes |
| Deja Vu - A Nightmare Comes True!! | 1988 | nes |
| Deja Vu I & II | 1999 | gbc |
| Deja Vu I & II - The Casebooks of Ace Harding | 1999 | gbc |
| Deliver Us the Moon | 2020 | ps4, switch, xboxone |
| Demetrios: The Big Cynical Adventure | 2016 | ps4, vita |
| Demetrios: The Big Cynical Adventure | 2018 | switch |
| Demetrios: The Big Cynical Adventure | 2017 | xboxone |
| Demonic Karma Summoner | 2016 | wiiu |
| Denjirou Sensei no Fushigi na Jikkenshitsu | 2008 | nds |
| Dennou Tenshi - Digital Ange | 1994 | pcengine |
| Deponia | 2016 | ps4, switch, xboxone |
| Deponia Doomsday | 2019 | ps4, switch, xboxone |
| Depths | 2020 | nes |
| Der Fluch der Osterinsel | 2010 | wii |
| Der Schatz der Delfine | 2012 | nds |
| Desert Kingdom | 2010 | ps2 |
| Desert Kingdom Portable | 2013 | psp |
| Desire | 2005 | ps2 |
| Desire | 1997 | saturn |
| Despera Drops | 2023 | switch |
| Dessert Love - Sweet Plus | 2006 | ps2 |
| Detective Barbie - The Mystery Cruise | 2000 | ps1 |
| Detective Instinct: Farewell, My Beloved | 2025 | switch |
| Detective Monroe - Murder at Sea | 2024 | gba |
| Detective Pikachu | 2018 | 3ds |
| Detective Pikachu Returns | 2023 | switch |
| Detonator Orgun | 1992 | segacd |
| Detroit: Become Human | 2018 | ps4 |
| Devicereign | 1999 | ps1 |
| Devil Summoner - Soul Hackers - Akuma Zensho Dainishuu | 1997 | saturn |
| Di Gi Charat Fantasy | 2001 | dreamcast |
| Di Gi Charat Fantasy Excellent | 2003 | ps2 |
| Dia no Kuni no Alice - Wonderful Mirror World | 2013 | psp |
| Dia no Kuni no Alice - Wonderful Wonder World | 2012 | psp |
| Diabolik - The Original Sin | 2009 | nds, ps2, psp, wii |
| Diabolik Lovers - Dark Fate | 2015 | vita |
| Diabolik Lovers - Haunted Dark Bridal | 2012 | psp |
| Diabolik Lovers - Limited V Edition | 2013 | vita |
| Diabolik Lovers - Lost Eden | 2017 | vita |
| Diabolik Lovers - Lunatic Parade | 2016 | vita |
| Diabolik Lovers - More, Blood | 2013 | psp |
| Diabolik Lovers - More, Blood - Limited V Edition | 2015 | vita |
| Diabolik Lovers - Vandead Carnival | 2014 | vita |
| Diabolik Lovers: Chaos Lineage | 2019 | switch |
| Diadroids World - Evil Teikoku no Yabou | 2001 | gba |
| Dice Dice Fantasia | 2009 | psp |
| Diddy Kong Racing | 1997 | n64, nds |
| Die Katze von Schroedinger | 1997 | ps1 |
| Die Stadt der verlorenen Kinder | 1997 | ps1 |
| Die drei Fragezeichen - Das verfluchte Schloss | 2009 | wii |
| Dies Irae - Amantes Amentes | 2012 | psp |
| Digimon Survive | 2022 | ps4, switch, xboxone |
| Digital Ange - Dennou Tenshi SS | 1997 | saturn |
| Digital Ehon Vol. 1 - Imadoki no Momotarou | 2002 | ps1 |
| Digital Ehon Vol. 2 - Imadoki no Kaguya-hime | 2002 | ps1 |
| Digital Ehon Vol. 3 - Imadoki no Saru Kani | 2002 | ps1 |
| Digital Ehon Vol. 4 - Imadoki no Hanasaka Jiisan | 2002 | ps1 |
| Digital Ehon Vol. 5 - Imadoki no Urashima-tarou | 2002 | ps1 |
| Digital Holmes | 2001 | ps2 |
| Digital Monster Ver. S - Digimon Tamers | 1998 | saturn |
| Dino Island | 1997 | saturn |
| Dino Island - Yokoku-hen | 1996 | saturn |
| Dino Master - Dig, Discover, Duel | 2005 | nds |
| Dinosaur | 2000 | gbc |
| Diorama Sensen Ijou Nashi - Stalingrad e no Michi | 2005 | ps2 |
| Dirty Harry | 1990 | nes |
| Discipline - Teikoku no Tanjyou | 2014 | wii |
| Discworld | 1996 | ps1 |