| Emio – The Smiling Man: Famicom Detective Club | 2024 | switch |
| Emit Value Pack | 1995 | ps1 |
| Emit Vol. 1 - Toki no Maigo | 1995 | 3do, saturn, snes |
| Emit Vol. 2 - Inochigake no Tabi | 1995 | 3do, saturn, snes |
| Emit Vol. 3 - Watashi ni Sayonara o | 1995 | 3do, saturn, snes |
| Emma at the Farm | 2004 | nds |
| Emma in the Mountains | 2008 | nds |
| Emmyrea | 2001 | ps1 |
| End Sleep | 2017 | vita |
| Endless Fables: Dark Moor | 2020 | ps4 |
| Endless Ocean 2 - Adventures of the Deep | 2009 | wii |
| Endless Ocean Luminous | 2024 | switch |
| Endlessly | 1995 | 3do |
| Enigma | 1998 | ps1 |
| Enigmatis 2: The Mists of Ravenwood | 2016 | ps4, xboxone |
| Enigmatis 3: The Shadow of Karkhala | 2018 | ps4 |
| Enigmatis: The Ghosts of Maple Creek | 2016 | ps4, xboxone |
| Enkaku Sousa - Shinjitsu eno 23nichikan | | psp |
| Enkan no Memoria - Kakera Tomoshi | 2018 | vita |
| Enkeltbillet | 2014 | psp |
| Ephemeral - Fantasy on Dark | 2018 | vita |
| Equinox | 1993 | snes |
| Erde - Nezu no Ki no Shita de | 2002 | dreamcast, ps2 |
| Erica | 2019 | ps4 |
| Erika to Satoru no Yume Bouken | 1988 | nes |
| Es | 2001 | dreamcast |
| Escape from Monkey Island | 2001 | ps2 |
| Escape the Museum | 2009 | wii |
| The Escapee | 2018 | dreamcast |
| Eternal Etude - Canvas 4 | 2011 | psp |
| Eternal Melody | 1996 | ps1, saturn |
| Eternights | 2023 | ps4, switch |
| Ether One | 2015 | ps4 |
| Etude Prologue - Yureugoku Kokoro no Katachi | 1998 | ps2, saturn |
| Etude Prologue Portable - Yureugoku Kokoro no Katachi | 2007 | psp |
| Eurasia Express Satsujin Jiken | 2000 | ps1 |
| Europa | 2024 | switch |
| Evan's Remains | 2020 | ps4 |
| Eve - Burst Error | 1997 | saturn |
| Eve - Burst Error Plus | 2003 | ps2 |
| Eve - Burst Error R | 2016 | vita |
| Eve - New Generation | 2006 | ps2 |
| Eve - The Fatal Attraction | 2001 | ps1 |
| Eve - The Lost One | 1998 | ps1, saturn |
| Eve Zero | 2000 | ps1 |
| Eve Zero Kanzenban - Ark of the Matter | 2001 | dreamcast |
| Even If Tempest | 2022 | switch |
| Eventide 2: Sorcerer's Mirror | 2017 | ps4, xboxone |
| Eventide 3: Legacy of Legends | 2018 | ps4, xboxone |
| Eventide: Slavic Fable | 2016 | ps4, xboxone |
| Ever 17 - The Out of Infinity | 2002 | dreamcast, ps2 |
| Ever 17 - The Out of Infinity - Premium Edition | 2003 | dreamcast, ps2 |
| Ever 17 - The Out of Infinity - Premium Edition | 2009 | psp |
| Ever Forward | 2021 | ps4, switch, xboxone |
| Ever17 - The Out of Infinity Premium Edition | 2009 | psp |
| Everblue 2 | 2002 | ps2 |
| Evergreen Avenue | 2001 | ps1 |
| Everybody's Gone to the Rapture | 2015 | ps4 |
| Everything | 2017 | ps4, switch |
| Exaskeleton | 2003 | xbox |
| The Excellent Dizzy Collection | 1994 | gg |
| The Exit 8 | 2024 | ps4, switch |
| Exodus Guilty | 1998 | ps1 |
| Exodus Guilty Neos | 2001 | dreamcast |
| Expeditie Robinson | 2010 | nds |
| Eyeshield 21 - DevilBats DevilDays | 2006 | gba |
| F - Fanatic | 2004 | ps2 |
| Faerie Dust Story - Meikyuu no Elfeene | 1990 | pcengine |
| Fahrenheit | 1995 | segacd |
| FairlyLife - MiracleDays | 2010 | psp |
| Fairy Life - Miracle Days | 2010 | psp |
| Fami Dave | 2024 | nes |
| FamiTsu PSP Vol.8 Tokubetsu Furoku - Irem Taikenban Shuu 2007 Kaki Tokubetsugou | | psp |
| Famicom Bunko - Hajimari no Mori | 1999 | snes |
| Famicom Detective Club: The Girl Who Stands Behind | 2021 | switch |
| Famicom Detective Club: The Missing Heir | 2021 | switch |
| Famicom Doubutsu Seitai Zukan! - Katte ni Shirokuma - Mori o Sukue no Maki! | 1989 | nes |
| Famicom Mini 27 - Famicom Tantei Club - Kieta Koukeisha - Zen, Kouhen | 2004 | gba |
| Famicom Mini 28 - Famicom Tantei Club Part II - Ushiro ni Tatsu Shoujo - Zen, Kouhen | 2004 | gba |
| Famicom Mukashibanashi - Shin Onigashima - Kouhen | 1987 | fds |
| Famicom Mukashibanashi - Shin Onigashima - Zenpen | 1987 | fds |
| Famicom Mukashibanashi - Yuuyuuki - Kouhen | 1989 | fds |
| Famicom Mukashibanashi - Yuuyuuki - Zenpen | 1989 | fds |
| Famicom Tantei Club - Kieta Koukeisha - Kouhen | 1988 | fds |
| Famicom Tantei Club - Kieta Koukeisha - Zenpen | 1988 | fds |
| Famicom Tantei Club Part II - Ushiro ni Tatsu Shoujo | 1998 | snes |
| Famicom Tantei Club Part II - Ushiro ni Tatsu Shoujo - Kouhen | 1989 | fds |
| Famicom Tantei Club Part II - Ushiro ni Tatsu Shoujo - Zenpen | 1989 | fds |
| Family Mysteries 2: Echoes of Tomorrow | 2020 | ps4 |
| Family Mysteries: Poisonous Promises | 2020 | ps4 |
| Fantasy Life | 2014 | 3ds |
| Fantasy Tavern Sextet Vol. 1: New World Days | 2020 | switch |
| Fantasy Tavern Sextet Vol. 2: Adventurer's Days | 2021 | switch |
| Fantasy Tavern Sextet Vol. 3: Postlude Days | 2021 | switch |
| Far-Out | 2020 | xboxone |
| Far: Lone Sails | 2019 | ps4, switch, xboxone |
| Fatal Frame - Maiden of Black Water | 2015 | wiiu |
| Fatal Twelve | 2021 | switch |
| Fate-Stay Night - Realta Nua | 2007 | ps2 |
| Fate-hollow ataraxia | 2014 | vita |