| Reservoir Rat | EU | 1998-10 |
Take 2 Interactive | Commercial |
| Retroid | WORLD | 2018 |
Mega Cat Studios | Unlicensed |
| Rewind Time | WORLD | |
| Unlicensed |
| Rex Run | WORLD | 2019-10 |
| Unlicensed |
| Rhythm Land | WORLD | |
| Unlicensed |
| Riddick Bowe Boxing | EU | 1995-10 |
Extreme Entertainment Group | Commercial |
| Riddick Bowe Boxing | US | 1994-01 |
Extreme Entertainment Group | Commercial |
| Riddick Bowe Boxing | US | 1994-01 |
Extreme Entertainment Group | Prototype |
| Rig Attack | WORLD | |
| Unlicensed |
| Ring Rage | JP | 1993-01-29 |
Natsume | Commercial |
| Ring Rage | US | 1993-01-29 |
Natsume | Commercial |
| Road Rash | EU | 1994-11 |
Ocean Software | Commercial |
| Road Rash | EU | 1994-11 |
Ocean Software | Prototype |
| Road Rash | US | 1994-06 |
Ocean Software | Commercial |
| Road Rash | US | 1994-06 |
Ocean Software | Prototype |
| Roadster | JP | 1990-10-19 |
Tonkin House | Commercial |
| Robby's Day Out | WORLD | 2020-09 |
| Unlicensed |
| Robin Hood - Prince of Thieves | DE | 1993-05-19 |
Virgin | Commercial |
| Robin Hood - Prince of Thieves | ES | 1993-05-19 |
Virgin | Commercial |
| Robin Hood - Prince of Thieves | EU | 1993-06 |
Virgin | Commercial |
| Robin Hood - Prince of Thieves | FR | 1993-05-19 |
Virgin | Commercial |
| Robin Hood - Prince of Thieves | US | 1993-06 |
Virgin | Commercial |
| RoboCop | EU | 1991-08 |
Ocean of America | Commercial |
| RoboCop | JP | 1991-03-01 |
Ocean of America | Commercial |
| RoboCop | US | 1990-12 |
Ocean of America | Commercial |
| RoboCop 2 | EU | 1992-03-19 |
Ocean Software | Commercial |
| RoboCop 2 | JP | 1992-03-19 |
Ocean Software | Commercial |
| RoboCop 2 | US | 1991-11 |
Ocean Software | Commercial |
| RoboCop Versus The Terminator | EU | 1995-04 |
Interplay | Commercial |
| RoboCop Versus The Terminator | US | 1994-08 |
Interplay | Commercial |
| Robot Ponkots - Sun Version - Comic Bom Bom Special Version | JP | |
| Commercial |
| Rock'n! Monster!! | JP | 1994-07-01 |
Hori | Commercial |
| Rockman 8 | TW | 1999 |
Yong Yong | Unlicensed |
| Rockman World | JP | 1991-07 |
Capcom | Commercial |
| Rockman World | JP | 1991-07 |
Capcom | Prototype |
| Rockman World 2 | JP | 1991-12 |
Capcom | Commercial |
| Rockman World 3 | JP | 1992-12 |
Capcom | Commercial |
| Rockman World 4 | JP | 1993-10 |
Capcom | Commercial |
| Rockman World 5 | JP | 1994-07 |
Capcom | Commercial |
| Rod Land | WORLD | 1993-04 |
The Sales Curve | Commercial |
| Rodland | EU | 1993-05 |
Jaleco | Commercial |
| Rodland | EU | 1993-05 |
Jaleco | Prototype |
| Roger Clemens' MVP Baseball | US | 1992-09 |
LJN | Commercial |
| Rolan's Curse | US | 1991-01 |
Sammy | Commercial |
| Rolan's Curse | US | 1991-01 |
Sammy | Prototype |
| Rolan's Curse II | US | 1992-10 |
Sammy | Commercial |
| Rolan's Curse II | US | 1992-02 |
Sammy | Prototype |
| Roommate Simulator | WORLD | 2023-08 |
thefuturetoday | Unlicensed |
| Rubble Saver | JP | 1991-05-17 |
Taito | Commercial |
| Rubble Saver II | JP | 1992-03-06 |
King Record Co. Ltd | Commercial |
| SD Gundam - SD Sengokuden - Kunitori Monogatari | JP | 1990-03-24 |
Bandai | Commercial |
| SD Gundam Gaiden - Lacroan' Heroes | JP | 1990-10-06 |
Bandai Namco | Commercial |
| SD Hiryuu no Ken Gaiden | JP | 1995-04-14 |
Culture Brain | Commercial |
| SD Hiryuu no Ken Gaiden 2 | JP | 1995 |
Culture Brain | Commercial |
| SD Lupin Sansei - Kinko Yaburi Daisakusen | JP | 1990-04-13 |
Banpresto | Commercial |
| SD Sengokuden 2 - Tenka Touitsu Hen | JP | 1992-01 |
Bandai Namco | Commercial |
| SD Sengokuden 3 - Chijou Saikyou Hen | JP | 1992-09 |
Bandai | Commercial |
| Sa-Ga 2 - Hihou Densetsu | JP | 1990-12 |
Square Enix | Commercial |
| Sa-Ga 2 - Hihou Densetsu | WORLD | 1990-12-14 |
Square Enix | Commercial |
| Sa-Ga 3 - Jikuu no Hasha | JP | 1991-12 |
Square Enix | Commercial |
| Sa-Ga 3 - Jikuu no Hasha | WORLD | 1991-12-13 |
Square Enix | Commercial |
| Sacred Meat | WORLD | 2023-08 |
Wrong Way Games | Unlicensed |
| Safe File | WORLD | |
| Unlicensed |
| Sagaia | JP | 1991-12-13 |
Taito | Commercial |
| Sagaia | WORLD | 1991-12-13 |
Taito | Commercial |
| Saigo no Nindou | JP | 1993-12 |
Irem | Commercial |
| Sakigake!! Otoko Juku - Meioutou Kessen | JP | 1990-08 |
Yutaka | Commercial |
| Sam Mallard - The Case of the Missing Swan | WORLD | 2022 |
snorpung | Unlicensed |
| Same Game | JP | 1997-04-25 |
Hudson Soft | Commercial |
| Samurai Shodown | EU | 1994-11 |
Takara | Prototype |
| Samurai Shodown | EU | 1994-11 |
Takara | Commercial |
| Samurai Shodown | US | 1994-11 |
Takara | Prototype |
| Samurai Shodown | US | 1994-11 |
Takara | Commercial |
| Sangokushi - Game Boy Ban | JP | 1992-09 |
Koei | Commercial |
| Sanrio Carnival | JP | 1991-05-11 |
Character Soft | Commercial |
| Sanrio Carnival 2 | JP | 1993-03-19 |
Character Soft | Commercial |
| Sanrio Uranai Party | JP | 1997-12-05 |
Imagineer | Commercial |
| Sarakon | EU | 1992 |
| Prototype |
| Schiffe Versenken | DE | 1998-11 |
Fantastic.TV | Commercial |
| Scotland Yard | JP | 1990-12-07 |
Cryo Interactive | Commercial |
| Sea Battle | EU | 1998-11 |
Infogrames | Commercial |
| Seaside Volley | JP | 1989-10-31 |
Activision | Commercial |
| Seiken Densetsu - Final Fantasy Gaiden | JP | 1991-06-28 |
Square Enix | Commercial |
| Seisenshi - Saint Paradise - Saikyou no Senshitachi | JP | 1992-11 |
Bandai | Commercial |
| Selection - Erabareshi Mono | JP | 1989-12 |
Kemco | Commercial |
| Selection I & II - Erabareshi Mono & Ankoku no Fuuin | JP | 1998-05-01 |
Kemco | Commercial |
| Selection II - Ankoku no Fuuin | JP | 1992-09-04 |
Kemco | Commercial |
| Sengoku Ninja-kun | JP | 1991-03-08 |
Sammy | Commercial |
| Sensible Soccer - European Champions | EU | 1993-01 |
Sony Imagesoft | Commercial |
| Serpent | US | 1990-04 |
Taxan USA Corp | Commercial |
| Shadow Warriors | EU | 1992 |
Tecmo | Commercial |
| Shanghai | JP | 1989-07-28 |
HAL Laboratory | Commercial |
| Shanghai | US | 1989-07 |
HAL Laboratory | Commercial |
| Shanghai Pocket | JP | 1998-08-06 |
Sunsoft | Commercial |
| Shaq Fu | US | 1995-10 |
Black Pearl Software | Commercial |
| Shark Attack | WORLD | |
| Unlicensed |
| Sheep It Up | WORLD | |
| Unlicensed |
| Shikinjou | JP | 1991-07-16 |
Toei Animation | Commercial |
| Shin Keiba Kizoku Pocket Jockey | JP | 1998-10-16 |
King Records | Commercial |
| Shin Nihon Pro Wrestling - Toukon Sanjuushi | JP | 1991-06 |
Varie | Commercial |