| If | WORLD | |
| Unlicensed |
| Ikari no Yousai | JP | 1991-02 |
Jaleco | Commercial |
| Ikari no Yousai 2 | JP | 1992-02-21 |
Jaleco | Commercial |
| Illuminated | WORLD | 2023-03 |
| Unlicensed |
| Impossible Gameboy | WORLD | 2021-09 |
Shadowsora | Unlicensed |
| In Your Face | US | 1990-12 |
Jaleco | Commercial |
| Indiana Jones - Saigo no Seisen | JP | 1994-12-23 |
Ubisoft | Commercial |
| Indiana Jones and the Last Crusade | EU | 1996-12-19 |
Ubisoft | Commercial |
| Indiana Jones and the Last Crusade | US | 1994-07 |
Ubisoft | Commercial |
| Indien dans la Ville, Un | EU | 1995 |
Titus | Commercial |
| InfoGenius Productivity Pak - Berlitz French Translator | EU | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz French Translator | US | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz German Translator | EU | |
| Prototype |
| InfoGenius Productivity Pak - Berlitz German Translator | US | |
| Prototype |
| InfoGenius Productivity Pak - Berlitz Japanese Translator | EU | |
| Prototype |
| InfoGenius Productivity Pak - Berlitz Japanese Translator | US | |
| Prototype |
| InfoGenius Productivity Pak - Berlitz Spanish Translator | EU | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz Spanish Translator | US | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Frommer's Travel Guide | US | 1991-09 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Personal Organizer and Phone Book | US | 1991 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Spell Checker and Calculator | US | 1991-09 |
GameTek | Commercial |
| InfoGenius Systems - Personal Organizer with Phone Book | EU | 1991 |
GameTek | Commercial |
| Initial D Gaiden | JP | 1998-03-06 |
Kodansha | Commercial |
| Interblocked | WORLD | |
| Unlicensed |
| International Space-Ball | WORLD | |
| Unlicensed |
| International Superstar Soccer | EU | 1998-06 |
Konami | Commercial |
| International Superstar Soccer | US | 1998-10 |
Konami | Commercial |
| Into the Blue | WORLD | 2019-04-09 |
Catskull Electronics | Unlicensed |
| Invasion From Spaaace! | WORLD | 2026-03 |
| Unlicensed |
| Ippatsu Gyakuten! DX Bakenou | JP | 1991-05-17 |
Asmik | Commercial |
| Iron Man X-O Manowar in Heavy Metal | EU | 1996-08 |
Acclaim Entertainment | Commercial |
| Iron Man X-O Manowar in Heavy Metal | US | 1996-11-14 |
Acclaim Entertainment | Commercial |
| Ishida Yoshio Tsumego Paradise | JP | 1990-12 |
Pony Canyon | Commercial |
| Ishido - The Way of Stones | JP | 1990-08-02 |
ASCII Corporation | Commercial |
| Ishido - The Way of Stones | US | 1990-11 |
ASCII Corporation | Commercial |
| Itsudemo! Nyan to Wonderful | JP | 1998-06-26 |
Banpresto | Commercial |