| DuckTales 2 | US | 1991 |
Capcom | Commercial |
| Hyper Dunk | EU | 1991 |
Konami | Commercial |
| InfoGenius Productivity Pak - Personal Organizer and Phone Book | US | 1991 |
GameTek | Commercial |
| InfoGenius Systems - Personal Organizer with Phone Book | EU | 1991 |
GameTek | Commercial |
| Jet Pak Jak | EU | 1991 |
| Prototype |
| Jet Pak Man | EU | 1991 |
| Prototype |
| Lunar Chase | US | 1991 |
Nintendo | Prototype |
| Nemesis | EU | 1991 |
Ultra Games | Commercial |
| Star Wars | US | 1991 |
Capcom | Commercial |
| Track Meet | US | 1991 |
Interplay | Commercial |
| Track Meet | US | 1991 |
Interplay | Prototype |
| Triumph | US | 1991 |
Hudson Soft | Prototype |
| Battle Bull | US | 1991-01 |
SETA | Commercial |
| Burai Fighter Deluxe | US | 1991-01 |
Taxan USA Corp | Commercial |
| Dragon's Lair - The Legend | WORLD | 1991-01 |
Elite | Commercial |
| InfoGenius Productivity Pak - Berlitz French Translator | EU | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz French Translator | US | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz Spanish Translator | EU | 1991-01 |
GameTek | Commercial |
| InfoGenius Productivity Pak - Berlitz Spanish Translator | US | 1991-01 |
GameTek | Commercial |
| Power Mission | US | 1991-01 |
NTV International Corporation | Commercial |
| Rolan's Curse | US | 1991-01 |
Sammy | Commercial |
| Rolan's Curse | US | 1991-01 |
Sammy | Prototype |
| The Chessmaster | US | 1991-01 |
Hi Tech Expressions | Commercial |
| Totsugeki Valations | JP | 1991-01 |
Atlus | Commercial |
| Contra | JP | 1991-01-08 |
Ultra Games | Commercial |
| Probotector | WORLD | 1991-01-08 |
Konami | Commercial |
| Totsugeki! Ponkotsu Tank | JP | 1991-01-08 |
Electro Brain | Commercial |
| Taito Chase H.Q | JP | 1991-01-11 |
Taito | Commercial |
| Balloon Kid | EU | 1991-01-31 |
Nintendo | Commercial |
| Double Dragon | EU | 1991-01-31 |
Tradewest | Commercial |
| Pinball - Revenge of the 'Gator | EU | 1991-01-31 |
Nintendo | Commercial |
| Pinball - Revenge of the 'Gator | EU | 1991-01-31 |
Nintendo | Prototype |
| Castelian | EU | 1991-02 |
Triffix | Commercial |
| Cool Ball | US | 1991-02 |
Takara | Commercial |
| Ikari no Yousai | JP | 1991-02 |
Jaleco | Commercial |
| Kung-Fu Master | US | 1991-02 |
Irem | Commercial |
| Kung-Fu Master | US | 1991-02 |
Irem | Prototype |
| NBA All-Star Challenge | US | 1991-02 |
Flying Edge | Commercial |
| Operation C | US | 1991-02 |
Ultra Games | Commercial |
| Radar Mission | US | 1991-02 |
Nintendo | Commercial |
| Onigashima Pachinkoten | JP | 1991-02-08 |
Coconuts Japan | Commercial |
| Ray-Thunder | JP | 1991-02-08 |
Nichibutsu | Commercial |
| BurgerTime Deluxe | WORLD | 1991-02-15 |
Data East | Commercial |
| Mikeneko Holmes no Kishidou | JP | 1991-02-15 |
ASK Kodansha | Commercial |
| F-1 Spirit | JP | 1991-02-28 |
Konami | Commercial |
| Racing Damashii | JP | 1991-02-28 |
Irem | Commercial |
| Bubble Bobble | US | 1991-03 |
Taito | Commercial |
| Bubble Bobble | US | 1991-03 |
Taito ~ Natsume | Prototype |
| Cyraid | US | 1991-03 |
Nexoft | Commercial |
| Doraemon - Taiketsu HimitsuDougu!! | JP | 1991-03 |
Epoch | Commercial |
| Jeopardy! | US | 1991-03 |
GameTek | Commercial |
| Loopz | WORLD | 1991-03 |
Mindscape | Commercial |
| Loopz | WORLD | 1991-03 |
Mindscape | Prototype |
| Maru's Mission | US | 1991-03 |
Jaleco | Commercial |
| Nobunaga's Ambition | US | 1991-03 |
Koei | Commercial |
| Super Scrabble | US | 1991-03 |
Milton Bradley | Commercial |
| RoboCop | JP | 1991-03-01 |
Ocean Software | Commercial |
| Sengoku Ninja-kun | JP | 1991-03-08 |
Sammy | Commercial |
| Super Momotarou Dentetsu | JP | 1991-03-08 |
Hudson Soft | Commercial |
| R-Type | JP | 1991-03-19 |
Irem | Commercial |
| Fastest Lap | JP | 1991-03-20 |
NTV International Corporation | Commercial |
| Family Jockey | JP | 1991-03-29 |
Namco | Commercial |
| Gem Gem | JP | 1991-03-29 |
Vic Tokai | Commercial |
| Chachamaru Panic | JP | 1991-04 |
Human Entertainment | Commercial |
| Doomsayer - A Hero's Crusade | US | 1991-04 |
Tokuma Shoten | Prototype |
| Extra Bases | US | 1991-04 |
Bandai | Commercial |
| Fish Dude | US | 1991-04 |
Sofel | Commercial |
| Little Master - Raikuban no Densetsu | JP | 1991-04 |
Tokuma Shoten | Commercial |
| Mickey Mouse | JP | 1991-04 |
Kemco | Commercial |
| Motocross Maniacs | EU | 1991-04 |
Ultra Games | Commercial |
| Nekketsu Koukou Soccer-bu - World Cup Hen | JP | 1991-04 |
Nintendo | Commercial |
| Pac-Man | US | 1991-04 |
Namco | Commercial |
| Solomon's Club | US | 1991-04 |
Tecmo | Commercial |
| Sumou Fighter - Toukaidou Basho | JP | 1991-04 |
DTMC | Commercial |
| Super Chinese Land 2 | JP | 1991-04 |
Culture Brain | Commercial |
| Tasmania Story | US | 1991-04 |
FCI | Commercial |
| WWF Superstars | US | 1991-04 |
LJN | Commercial |
| Parodius Da! | JP | 1991-04-05 |
Konami | Commercial |
| Solomon's Club | JP | 1991-04-05 |
Tecmo | Commercial |
| Gargoyle's Quest | EU | 1991-04-11 |
Capcom | Commercial |
| Final Reverse | JP | 1991-04-12 |
Toei Animation | Commercial |
| World Ice Hockey | JP | 1991-04-12 |
Athena | Commercial |
| World Ice Hockey | US | 1991-04-12 |
Athena | Prototype |
| Cave Noire | JP | 1991-04-19 |
Konami | Commercial |
| Super Robot Taisen | JP | 1991-04-20 |
Banpresto | Commercial |
| Hugo | WORLD | 1991-04-26 |
Kemco | Unlicensed |
| Lucky Monkey | JP | 1991-04-26 |
Natsume | Commercial |
| Mickey Mouse II | JP | 1991-04-26 |
Kemco | Commercial |
| Mini Putt | EU | 1991-04-26 |
A Wave | Prototype |
| Mini Putt | US | 1991-04-26 |
A Wave | Prototype |
| Mini-Putt | JP | 1991-04-26 |
A Wave | Commercial |
| Karakuri Kengou Den Musashi Lord | JP | 1991-04-27 |
Yutaka | Commercial |
| Torpedo Range | JP | 1991-04-27 |
SETA | Commercial |
| The Chessmaster | EU | 1991-04-30 |
Hi Tech Expressions | Commercial |
| Atomic Punk | US | 1991-05 |
Hudson Soft | Commercial |
| Castelian | US | 1991-05 |
Triffix | Commercial |
| Castelian | US | 1991-05 |
Triffix | Prototype |
| David Crane's The Rescue of Princess Blobette | US | 1991-05 |
Jaleco | Prototype |
| Go! Go! Tank | US | 1991-05 |
Electro Brain | Commercial |
| Hatris | US | 1991-05 |
Bullet-Proof Software | Commercial |