| Sotsugyou - Graduation | 1993 | pcengine |
| Sotsugyou - Graduation - Final | 1994 | 3do |
| Sotsugyou - Graduation S | 1997 | saturn |
| Sotsugyou II - Neo Generation | 1994 | pcengine |
| Sotsugyou II - Neo Generation | 1995 | ps1 |
| Sotsugyou II - Neo Generation | 1995 | saturn |
| Sotsugyou II Special - Neo Generation | 1995 | 3do |
| Sotsugyou III - Wedding Bell | 1998 | ps1, saturn |
| Sotsugyou M - Seito Kaichou no Karei naru Inbou | 1998 | ps1 |
| Sotsugyou for WonderSwan | 1999 | ws |
| Sougaku Toshi Osaka | 1999 | ps1 |
| Souten no Shiroki Kami no Kura - Great Peak | 1998 | ps1 |
| Space Attack | 1982 | a2600 |
| Space Shuttle | 1994 | 3do |
| Space Shuttle - A Journey Into Space | 1983 | a2600, a5200 |
| Space Shuttle Project | 1991 | nes |
| Space Station Tycoon | 2007 | wii |
| Space War Attack | 2005 | ps2 |
| Space War ~ Space Combat | 1978 | a2600 |
| Spacebase Startopia | 2021 | ps4, switch |
| Speaking Simulator | 2020 | switch |
| Spintires: MudRunner | 2017 | ps4, xboxone |
| Spiritfarer | 2020 | ps4, switch |
| Spitfire Heroes - Tales of the Royal Air Force | 2008 | nds |
| SpongeBob SquarePants - Frantic Fry Cook | 2009 | nds |
| Spore Creatures | 2008 | nds |
| Spore Hero | 2009 | wii |
| Sprung - The Dating Game | 2004 | nds |
| Star Fighter | 1995 | 3do, ps1, saturn |
| Star Monja | 1998 | ps1 |
| Star Raiders | 1982 | a2600, a5200 |
| Star Trek - Starfleet Academy - Starship Bridge Simulator | 1994 | 32x, snes |
| Star Trek - The Next Generation | 1993 | gb, gg, nes |
| Star Trek Generations - Beyond the Nexus | 1994 | gb |
| Star Wars: Squadrons | 2020 | ps4 |
| StarLancer | 2000 | dreamcast |
| Starlight Scramble - Ren'ai Kouhosei | 1998 | ps1 |
| Starmaster - International Edition | 1982 | a2600 |
| Starpoint Gemini 2 | 2014 | xboxone |
| Stealth ATF | 1989 | nes |
| Steel Battalion | 2002 | xbox |
| Steel Battalion - Heavy Armor | 2012 | xbox360 |
| Steel Talons | 1991 | arcade, genesis, lynx, snes |
| Story of Seasons | 2015 | 3ds |
| Story of Seasons - Trio of Towns | 2017 | 3ds |
| Story of Seasons: Friends of Mineral Town | 2019 | switch |
| Story of Seasons: Pioneers of Olive Town | 2021 | switch |
| Street Riders | 2006 | psp |
| Strike Suit Zero | 2014 | ps4 |
| Style Book - Fushigi Boshi no Futago Hime Gyu! | 2006 | nds |
| Style Lab - Fashion Design | 2010 | nds |
| Style Lab - Makeover | 2009 | nds |
| Style Savvy | 2016 | wiiu |
| Styx | 2022 | n64 |
| Sub | 1998 | ps1 |
| Submarine Commander | 1982 | a2600 |
| Subwar 2050 | 1994 | cd32 |
| Sugar^2 Rune - Koi mo Oshare mo Pick-Up | 2005 | ps2 |
| Suguroku DS | 2009 | nds |
| Sumikko Gurashi: Oheya no Sumi de Tabi Kibun Sugoroku | 2020 | switch |
| Super Air Diver | 1993 | snes |
| Super Air Diver 2 | 1995 | snes |
| Super Battletank | 1994 | gb |
| Super Battletank | 2001 | gg |
| Super Battletank 2 | 1994 | snes |
| Super Dogfight | 1994 | snes |
| Super Hind | 2008 | psp |
| Super Hornet FA 18F | 2004 | gba |
| Super Producers - Mezase Show Biz Kai | 1999 | dreamcast |
| Super Strike Eagle | 1993 | snes |
| Super Wing Commander | 1994 | 3do |
| Super Yakyuudou | 1996 | snes |
| SuperLite 1500 Series - A Ressha de Ikou 4 - Evolution Global | 2003 | ps1 |
| SuperLite 1500 Series - A5 - A Ressha de Ikou 5 | 2003 | ps1 |
| SuperLite 1500 Series - Ano Ko Doko no Ko - Endless Season | 1999 | ps1 |
| SuperLite 1500 Series - Densetsu-juu no Ana - Monster Complete World Ver. 2 | 2002 | ps1 |
| SuperLite 1500 Series - F1 Grand Prix 1996 - Team Un'ei Simulation | 1999 | ps1 |
| SuperLite 1500 Series - Kaiteiban Shichuu Suimei - Mark Yazaki Kanshuu | 2001 | ps1 |
| SuperLite 1500 Series - Pao Leeming Kanshuu - Fuusui Nyuumon | 2002 | ps1 |
| SuperLite 1500 Series - Wizard's Harmony | 2002 | ps1 |
| SuperLite 1500 Series - Wizard's Harmony 2 | 2002 | ps1 |
| SuperLite 1500 Series - Wizard's Harmony R | 2002 | ps1 |
| SuperLite 2000 Vol. 17 - Hakoniwa Tetsudou - Blue Train Tokkyuu-hen | 2002 | ps2 |
| SuperLite 2000 Vol. 36 - Youkoso Hitsuji-mura | 2008 | ps2 |
| SuperLite 2000 Vol. 41 - Tokyo Bus Guide 2 | 2005 | ps2 |
| SuperLite 2000 Vol. 5 - Tokyo Bus Guide - Kyou kara Kimi mo Untenshu | 2001 | ps2 |
| Surgeon Simulator | 2014 | ps4, switch |
| Surviving Mars | 2018 | ps4, xboxone |
| Surviving the Aftermath | 2021 | ps4, switch, xboxone |
| Survivor | 2009 | wii |
| Sushi Academy | 2004 | nds |
| Sushi Go-Round | 2004 | nds |
| The Sushi Spinnery | 2020 | ps4 |
| Suspension Railroad Simulator | 2015 | wiiu |
| Suzumiya Haruhi no Tomadoi | 2008 | ps2 |
| Sven-Goeran Eriksson's World Manager 2002 | 2002 | ps2 |
| Sweet 16 | 2009 | nds |
| Sweetest Thing | 2016 | wiiu |
| Taco Master | 2015 | vita |
| Tactical Fighter | 1997 | saturn |