| Shin Bokujou Monogatari - Pure - Innocent Life | 2007 | ps2 |
| Shin Seiki Evangelion - Ayanami Ikusei Keikaku | 2002 | dreamcast |
| Shin Seiki Evangelion - Ayanami Ikusei Keikaku with Asuka Hokan Keikaku | 2003 | ps2 |
| Shiny Ski Resort | 2020 | ps4 |
| Shiren Monsters - Netsal | 2004 | gba |
| Shock Wave | 1994 | 3do, ps1 |
| Shockwave 2 - Beyond the Gate | 1995 | 3do |
| Shockwave Assault | 1996 | saturn |
| Shoujo Mahou Gaku Littlewitch Romanesque - Aria to Kaya to Kuro no Tou | 2007 | ps2 |
| Shoukan Shoujo - Elemental Girl Calling | 2007 | ps2 |
| Shrek - Oger und Dresel | 2007 | nds |
| Shrek - Ogres & Dronkeys | 2007 | nds |
| Shrek - Ogres et Dranons | 2007 | nds |
| Shrek - Ogritos y Drasnos | 2007 | nds |
| Shrek - Orchetti e Ciuchini | 2007 | nds |
| The Shrouded Isle | 2019 | switch |
| Shuttle Orbiter | 1984 | a2600 |
| Shuukan Pro Wres Kanshuu - Pro Wres Sengokuden | 1997 | ps1 |
| Sid Meier's Civilization Revolution | 2008 | nds, ps3, xbox360 |
| Sidewinder F | 2001 | ps2 |
| Sidewinder Max | 2000 | ps2 |
| Sidewinder V | 2003 | ps2 |
| Silent Service | 1989 | nes |
| Sim City | 2006 | wii |
| Sim Town | 1997 | ps1 |
| SimAnimals | 2009 | nds, wii |
| SimAnimals - Africa | 2009 | nds |
| SimAnimals - Africa | 2009 | wii |
| SimCity | 1991 | nes, snes |
| SimCity - Creator | 2008 | nds |
| SimCity 2000 | 1998 | n64 |
| SimCity Creator | 2008 | wii |
| SimCity DS | 2004 | nds |
| SimCity DS 2 - Kodai kara Mirai e Tsuzuku Machi | 2008 | nds |
| SimCity Jr | 1996 | snes |
| SimCopter 64 | 1997 | n64 |
| SimEarth - The Living Planet | 1991 | pcengine, segacd, snes, wii |
| SimPeople - Ochanoma Gekijou | 2000 | ps2 |
| Simple 1500 Jitsuyou Series Vol. 02 - Katei no Fuusui | 2000 | ps1 |
| Simple 1500 Jitsuyou Series Vol. 03 - Seimei Handan | 2000 | ps1 |
| Simple 1500 Jitsuyou Series Vol. 04 - Ryouri - Teiban Ryouri Recipe-shuu | 2000 | ps1 |
| Simple 1500 Jitsuyou Series Vol. 06 - Cocktail no Recipe | 2001 | ps1 |
| Simple 1500 Jitsuyou Series Vol. 07 - Tanoshiku Manabu Unten Menkyo | 2001 | ps1 |
| Simple 1500 Jitsuyou Series Vol. 10 - Tarot Uranai | 2001 | ps1 |
| Simple 1500 Series Vol. 101 - The Sentou | 2003 | ps1 |
| Simple 1500 Series Vol. 102 - The Densha Untenshu - Densha de Go! Nagoya Tetsudou-hen | 2002 | ps1 |
| Simple 1500 Series Vol. 103 - The Ganso Densha Untenshi - Densha de Go! | 2003 | ps1 |
| Simple 1500 Series Vol. 21 - The Yakyuu | 2000 | ps1 |
| Simple 1500 Series Vol. 21 - The Yakyuu - Pro Yakyuu Jitsumeiban | 2001 | ps1 |
| Simple 1500 Series Vol. 96 - The Yakyuu 2 - 2002 Pro Yakyuu | 2002 | ps1 |
| Simple 2000 Series Ultimate Vol. 10 - Love - Songs - Idol ga Classmate | 2003 | ps2 |
| Simple 2000 Series Ultimate Vol. 25 - Chou Saisoku! Zokusha King Bore Up no Bore Up - Butchigiri Densetsu 2 Kai | 2005 | ps2 |
| Simple 2000 Series Vol. 115 - The Roomshare toyuu Seikatsu | 2007 | ps2 |
| Simple 2000 Series Vol. 117 - The Reisen | 2007 | ps2 |
| Simple 2000 Series Vol. 15 - The Rugby | 2002 | ps2 |
| Simple 2000 Series Vol. 22 - The Tsuukin Densha Untenshi - Densha de Go! 3 - Tsuukin-hen | 2003 | ps2 |
| Simple 2000 Series Vol. 32 - The Sensha | 2003 | ps2 |
| Simple 2000 Series Vol. 35 - The Helicopter | 2003 | ps2 |
| Simple 2000 Series Vol. 36 - The Musume Ikusei Simulation - Otousan to Issho | 2003 | ps2 |
| Simple 2000 Series Vol. 59 - The Uchuujin to Hanasou! Uchuujin tte Naani | 2001 | ps2 |
| Simple 2000 Series Vol. 78 - The Uchuu Daisensou | 2005 | ps2 |
| Simple 2000 Series Vol. 98 - The Roman Sabou - Meshimase Roman Sabou | 2004 | ps2 |
| Simple DS Series Vol. 20 - The Senkan | 2007 | nds |
| Simple DS Series Vol. 34 - The Haisha-san | 2008 | nds |
| Simple Outlaws DX Gaiden - Chou Saisoku! Zokusha King Bore Up - Butchigiri Densetsu 2 | 2004 | ps2 |
| The Sims | 2003 | gba, gc |
| The Sims | 2003 | gba, gc, ps2, xbox |
| The Sims 2 | 2005 | gba, gc, nds, ps2, psp, xbox |
| The Sims 2 - Apartment Pets | 2008 | nds |
| The Sims 2 - Castaway | 2007 | nds |
| The Sims 2 - Castaway | 2007 | ps2, psp, wii |
| The Sims 2 - Dr. Dominic no Inbou | 2005 | psp |
| The Sims 2 - Pet Wan Nyan Life | 2006 | psp |
| The Sims 2 - Pets | 2006 | gba, gc, nds, ps2, psp, wii |
| The Sims 3 | 2010 | 3ds, nds, ps3, wii, xbox360 |
| The Sims 3 - Pets | 2011 | 3ds |
| The Sims 3 - Pets | 2011 | ps3, xbox360 |
| The Sims 4 | 2017 | ps4, xboxone |
| Simulation Pro Yakyuu '99 | 1999 | ps1 |
| Simulation RPG Tkool | 1998 | ps1, saturn |
| Simulation Zoo | 1997 | saturn |
| The Sky Crawlers - Innocent Aces | 2008 | wii |
| Sky Mission | 1992 | snes |
| Sky Patrol | 1982 | a2600 |
| Sky Target | 1997 | saturn |
| SkyCopter II | | jaguar |
| Skydiving Extreme | 2001 | ps1 |
| Skydrift Infinity | 2021 | switch |
| Sledge 3D | | vectrex |
| Slots - Pharaoh's Riches | 2016 | wiiu |
| Snoopy vs. the Red Baron | 2006 | ps2, psp |
| SnowRunner | 2020 | ps4, switch |
| Snowpack Park | 2010 | wii |
| Soccer Life 2 | 2005 | ps2 |
| Soccer Life 2 - We are Challengers to Europe | 2006 | ps2 |
| Soccer Life! | 2004 | ps2 |
| Soccer Life! We are Challengers to Europe | 2005 | ps2 |
| Sold Out | 1997 | ps1 |
| Solo Crisis | 1998 | saturn |
| Sotsugyou - Crossworld | 1996 | ps1 |