| Sonic Eraser | 1991 | genesis |
| Soon Shine | 2014 | wiiu |
| Soreike! Anpanman - Minna de Hiking Game! | 1992 | nes |
| Soreyuke Ebisumaru Karakuri Meiro - Kieta Goemon no Nazo!! | 1996 | snes |
| Soreyuke!! Kid | 1997 | gb |
| Sorobang | 2000 | wsc |
| Souko Ban Deluxe | 1990 | arcade |
| Soukoban | 1985 | sg1000 |
| Soukoban - Nanmon Shinan | 1999 | ps1 |
| Soukoban 2 | 1990 | gb |
| Soukoban Basic | 1997 | ps1 |
| Soukoban Basic 2 | 1998 | ps1 |
| Soukoban World | 1990 | pcengine |
| Soul Bubbles | 2008 | nds |
| Sound Qube | 1998 | ps1 |
| Sound Qube | 1998 | saturn |
| Soutenryu | 2000 | arcade |
| Soutenryuu - The Arcade | 2003 | ps2 |
| Space Bust-A-Move | 2008 | nds |
| Space Hexcite - Maetel Legend EX | 2001 | gba |
| Space Walk 3030 | 2020 | nes |
| Sparkle | 2013 | vita |
| Sparkle 2 | 2014 | ps3, ps4, switch, vita, xboxone |
| Sparkle Unleashed | 2015 | ps3, vita, xboxone |
| Sparkle Unleashed | 2020 | ps4 |
| Sparkz | 1992 | arcade |
| Speccies 2 | 2020 | sms |
| The Spectrum Retreat | 2018 | switch, xboxone |
| Speed Coin | 1984 | arcade |
| SpeedThru - Potzol's Puzzle | 2012 | 3ds |
| Spider | 1994 | arcade |
| Spider: Rite of the Shrouded Moon | 2015 | ps4, vita |
| Spin Jam | 2000 | ps1 |
| Spin Pair | 1990 | pcengine |
| Spiral Splatter | 2017 | vita, xboxone |
| Splash Lake | 1992 | pcengine |
| The Splatters | 2012 | xbox360 |
| Splice | 2015 | ps3 |
| Splitz | 1993 | gb |
| Splitz - Nigaoe 15 Game | 1993 | gb |
| Sport Freaks | 1996 | cdi |
| Sports Match | 1989 | arcade |
| Spot - The Video Game | 1990 | gb, nes |
| Spot - The Video Game | 1990 | gb |
| Spot the Differences | 2014 | 3ds |
| Spot the Differences - Party! | 2013 | wiiu |
| Spot the Differences! | | psp |
| Spot the Differences! | 2011 | wii |
| Spud's Adventure | 1991 | gb |
| Spy Chameleon | 2015 | ps4, vita, xboxone |
| SpyToy | 2005 | ps2 |
| Square Deal | 1991 | nes |
| Squares | 2015 | vita |
| Squishy Tank | 2008 | nds |
| Stack Columns | 1994 | arcade |
| Stakk'm | 1991 | nes |
| Star Mobile | 1991 | genesis, pcengine |
| Star Sweep | 1997 | gb |
| Star Sweep | 2001 | ps1 |
| Star Sweep | 1997 | arcade |
| Star Trigon | 2002 | arcade |
| StarDrone | 2011 | ps3 |
| StarSweep | 1997 | ps1 |
| Stargate | 1994 | gb, genesis, gg, snes |
| Starz | 2004 | nds |
| Steal See | 2000 | arcade |
| Steam Express | 2007 | ps2 |
| Steel Worker | 1980 | arcade |
| Stickybear Math | 1994 | cdi |
| Still Time | 2017 | vita |
| Stoat XV | 2023 | genesis |
| Storm | 2013 | xbox360 |
| Stressless Lesson - Les Les | 1997 | ps1 |
| The Stretchers | 2019 | switch |
| Stretchmo | 2015 | 3ds |
| Strike Solitaire | 2015 | vita |
| Strike Solitaire 2 | 2015 | vita |
| Studio P | 1996 | ps1 |
| SubaraCity | 2019 | xboxone |
| Sudo King | | nes |
| Sudoku | 2007 | lynx |
| Sudoku | 2007 | nes |
| Sudoku | 2006 | psp |
| Sudoku | 2007 | sms |
| Sudoku + 7 Other Complex Puzzles by Nikoli | 2012 | 3ds |
| Sudoku - The Puzzle Game Collection | 2011 | 3ds |
| Sudoku 2007 | 2007 | nes |
| Sudoku 23 | 2023 | nes |
| Sudoku Ball - Detective | 2009 | nds, wii |
| Sudoku Challenge! | 2008 | wii |
| Sudoku Coach | 2007 | psp |
| Sudoku DS - Nikoli no 'Sudoku' Ketteiban | 2008 | nds |
| Sudoku Party | 2017 | wiiu |
| Sudoku by Nikoli | 2013 | 3ds |
| Sudoku to 3-Tsu no Puzzle - Nikoli no Puzzle Variety | 2011 | 3ds |
| Sudokumaniacs | 2004 | nds |
| Sudokuro | 2004 | nds |
| Sueddeutsche Zeitung Wissen - Mehr Kreuzwortraetsel | 2004 | nds |
| Sum-eoitneun Deongdalireul Chat-ara! | 1993 | arcade |
| The Sun - Crossword Challenge | 2008 | nds |