| The Rub Rabbits! | 2005 | nds |
| Rubik's Cube | 1984 | a2600 |
| Rubik's Cube | 2016 | wiiu |
| Rubik's Cube 3-D | 1982 | a2600 |
| Rubik's Puzzle Galaxy - RUSH | 2009 | wii |
| Rubik's Puzzle World | 2008 | nds, wii |
| Rugrats - Totally Angelica | 2000 | gbc |
| Rugrats - Typisch Angelica | 2000 | gbc |
| Rune Lord | 2020 | xboxone |
| Runes | 2020 | genesis |
| Rupupu Cube - Lup Salad Portable ...Matatabi | 2010 | psp |
| Rush | 2013 | wiiu |
| SCRMNN | 1983 | a2600 |
| SD Gundam - Power Formation Puzzle | 1996 | snes |
| SD Lupin Sansei - Kinko Yaburi Daisakusen | 1990 | gb |
| SMS Capture GO | 2026 | sms |
| Sacra Terra - Kiss of Death | 2014 | ps3 |
| Sadari | 1993 | arcade |
| Safecracker | 2008 | wii |
| Safecracker - The Ultimate Puzzle Adventure | 2009 | nds |
| Saint & Sinner | 2006 | ps2 |
| Saku Saku Animal Panic | 2008 | wii |
| Sakura Taisen - Hanagumi Taisen Columns 2 | 2000 | dreamcast |
| Same Game | 1997 | gb |
| Same Game | 1996 | snes |
| Same Game FX | 1995 | pcfx |
| Same Game Wii | 2009 | wii |
| Samsara | 2018 | xboxone |
| Sankokushi | 1996 | arcade |
| Sanrio Carnival | 1991 | gb |
| Sanrio Carnival | 1990 | nes |
| Sanrio Carnival 2 | 1993 | gb |
| Sanrio Carnival 2 | 1993 | nes |
| Santa Claus Is Comin' to Town! | 2011 | wii |
| Santa Claus no Takarabako | 1987 | fds |
| Santa Simon | 2006 | a7800 |
| Santa's Snowman | 2022 | nes |
| Sarakon | 1992 | gb |
| Scaffolder | 1992 | svision |
| Scarabeus | 1991 | nes |
| ScreamRide | 2015 | xbox360, xboxone |
| Scribblenauts Collection | 2013 | nds |
| Scribblenauts Mega Pack | 2018 | switch, xboxone |
| Scribblenauts Unmasked - A DC Comics Adventure | 2013 | 3ds, wiiu |
| SeaWorld Adventure Parks - Shamu's Deep Sea Adventures | 2005 | gc, ps2, xbox |
| Search Eye | 1999 | arcade |
| Search Eye Plus | 1999 | arcade |
| Secret Mysteries in London | 2012 | 3ds |
| Secret Mysteries in London - Update 1.1 | 2012 | 3ds |
| Secret of Evangelion Portable | 2007 | psp |
| Secret of the Pharaohs | 1980 | o2 |
| See See Find Out | 1999 | arcade |
| Sega Ages 2500 Series Vol. 12 - Puyo Puyo Tsuu - Perfect Set | 2004 | ps2 |
| Sega Ages 2500 Series Vol. 28 - Tetris Collection | 2007 | ps2 |
| Sega Ages 2500 Series Vol. 7 - Columns | 2003 | ps2 |
| Sega Tetris | 2000 | dreamcast |
| Sega Tetris | 1999 | arcade |
| SegaSonic Bros | 2018 | genesis |
| SegaSonic Bros | 1992 | arcade |
| Segata Sanshirou - Shinken Yuugi | 1998 | saturn |
| Segle | 2022 | sms |
| Sekai Fushigi Hakken! DS - Densetsu no Hitoshi-kun Ningyou o Sagase! | 2009 | nds |
| Semispheres | 2017 | ps4, switch, vita |
| Sen-Know | 1999 | arcade |
| Senha | 2007 | sms |
| Sennou Millennium | 2000 | ws |
| Senseless City | 2022 | nes |
| Sextris | 1997 | snes |
| Sexy Boom | 1992 | arcade |
| Sexy Yakyuuken Adventure II - Gal's Dungeon Part II | 1989 | fds |
| Sfida al Tetris Magico | 1999 | ps1 |
| Shadow Assault - Tenchu | 2008 | xbox360 |
| ShadowPlay | 2010 | wii |
| Shadowgate 64 - Trials of the Four Towers | 1999 | n64 |
| Shan Liang San He Yi | 2004 | arcade |
| Shanghai | 2005 | nds |
| Shanghai | 2006 | psp |
| Shanghai - Banri no Choujou | 1996 | pcfx |
| Shanghai - Banri no Choujou | 1995 | ps1 |
| Shanghai - Banri no Choujou - The Great Wall | 1994 | 3do, saturn |
| Shanghai - Great Moments | 1996 | ps1, saturn |
| Shanghai - Mateki Buyuu | 1998 | ps1 |
| Shanghai - Sangoku-pai Tougi | 2002 | ps2 |
| Shanghai - Shouryuu Sairin | 2001 | ps1 |
| Shanghai - The Great Wall / Shanghai Triple Threat | 1995 | arcade |
| Shanghai - Triple-Threat | 1995 | 3do, saturn |
| Shanghai - True Valor | 1999 | ps1 |
| Shanghai 3D Cube | 2011 | 3ds |
| Shanghai II | 1990 | pcengine |
| Shanghai II | 1989 | arcade |
| Shanghai III | 1993 | arcade, snes |
| Shanghai Matekibuyuu | 1998 | arcade |
| Shanghai Matekibuyuu | 2011 | arcade |
| Shanghai Sangokuhai Tougi | 2002 | arcade |
| Shanghai Shoryu Sairin | 2000 | arcade |
| Shanliang San He Yi | 2004 | arcade |
| Sharuui Takoron | 2007 | wii |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Handanryoku | 2005 | nds |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Kiokuryoku | 2005 | nds |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Shuuchuuryoku | 2005 | nds |