| Shifting World | 2013 | 3ds |
| Shijou Saidai no Soukoban | 1989 | genesis |
| Shin Megami Tensei - Devil Children - Puzzle de Call! | 2003 | gba |
| Shingata Kururin Pa! | 1996 | ps1, saturn |
| Shinshuku Taisen - It's a Nony! | 1997 | ps1 |
| Shippuu no Usagi-Maru - Nazo no Karakurijou | 2015 | 3ds |
| Shisensho - Joshiryo-Hen | 1989 | arcade |
| Shisensho II | 1993 | arcade |
| Shisenshou - Match-Mania | 1990 | gb |
| Shootagem | 2023 | sms |
| Shotest Shogi | 2008 | xbox360 |
| Shove It! ...The Warehouse Game | 1990 | genesis |
| Shunkan Puzz Loop | 2006 | nds |
| Shuzi Leyuan | 1996 | arcade |
| Sichuan II | 1989 | arcade |
| Sightseeing Puzzle - Echter Puzzlespass fuer Unterwegs | 2004 | nds |
| Silhouette Stories | 1996 | ps1 |
| Simone | 2021 | jaguarcd |
| Simple 1500 Series - Hello Kitty Vol. 02 - Illust Puzzle | 2001 | ps1 |
| Simple 1500 Series Vol. 20 - The Puzzle | 1999 | ps1 |
| Simple 1500 Series Vol. 37 - The Illust Puzzle & Slide Puzzle | 2000 | ps1 |
| Simple 1500 Series Vol. 46 - The Mahjong Ochigee - Raku Jongg | 2000 | ps1 |
| Simple 1500 Series Vol. 48 - The Puzzle 2 | 2000 | ps1 |
| Simple 1500 Series Vol. 51 - The Jigsaw Puzzle | 2000 | ps1 |
| Simple 1500 Series Vol. 79 - The Shisenshou | 2001 | ps1 |
| Simple 1500 Series Vol. 93 - The Puzzle Bobble - Puzzle Bobble 4 | 2002 | ps1 |
| Simple 2000 Series Vol. 23 - The Puzzle Collection 2,000-mon | 2003 | ps2 |
| Simple 2000 Series Vol. 62 - The Super Puzzle Bobble DX | 2004 | ps2 |
| Simple 2500 Series Portable!! Vol. 10 - The IQ Cube - Moyatto Atama o Puzzle de Sukkiri! | 2007 | psp |
| Simple 2500 Series Portable!! Vol. 7 - The Doko Demo Kanji Quiz 2006 | 2006 | psp |
| Simple Character 2000 Series Vol. 02 - Afro-ken - The Puzzle | 2001 | ps1 |
| Simple Character 2000 Series Vol. 14 - Nante Tantei Idol - The Jigsaw Puzzle | 2002 | ps1 |
| Simple DS Series Vol. 28 - The Illust Puzzle & Suuji Puzzle 2 | 2007 | nds |
| Simple DS Series Vol. 33 - The Crossword & Kanji Puzzle | 2008 | nds |
| Simple Series Vol. 2 - The Number Puzzle neo | 2008 | wii |
| Sindbad Mystery | 1983 | arcade, sg1000 |
| Sinkr | 2020 | xboxone |
| Six Sides of the World | 2017 | wiiu |
| Sketchcross | 2015 | vita |
| Skipp and Friends - Unexpected Journey | 2014 | snes |
| Sklad No18 | 1997 | nes |
| Skweek | 1991 | gg, pcengine |
| SlabWell | 2019 | ps4, xboxone |
| Slam Bolt Scrappers | 2011 | ps3 |
| Slayaway Camp: Butcher's Cut | 2017 | ps4, switch, vita |
| Slayaway Camp: The Butcher's Cut | 2017 | xboxone |
| Sleep | | snes |
| Sleepin' Deeply | 2020 | xboxone |
| Sleepwalker | 2010 | xbox360 |
| Slice It! | 2016 | 3ds |
| Slider | 1991 | gg |
| Slingo Quest | 2008 | nds |
| Slither Link | 2000 | ws |
| Sliver | 1996 | arcade |
| Sloane to MacHale no Nazo no Story | 2009 | nds |
| Sloane to MacHale no Nazo no Story 2 | 2009 | nds |
| Small Radios Big Televisions | 2016 | ps4 |
| Smart As | 2012 | vita |
| Smart Bomb | 2005 | psp |
| Smart Mouse | 2017 | genesis |
| SmileyWorld - Island Challenge | 2009 | nds |
| SnailNES | 2022 | nes |
| Snakebird | 2016 | gb |
| Snakebird Complete | 2023 | switch |
| Sneak 'n Peek | 1982 | a2600 |
| Sneakers | 2002 | xbox |
| Sneezies | 2011 | wii |
| Snipperclips | 2017 | switch |
| Snipperclips Plus | 2017 | switch |
| Snood | 2001 | gba |
| Snood 2 - On Vacation | 2004 | gba, nds |
| Snoopy - Magic Show | 1990 | gb |
| Snoopy no Hajimete no Otsukai | 1996 | gb |
| Snoopy's Magic Show | 1990 | gb |
| The Snow Queen Quest | 2007 | ps2 |
| Snowy - Treasure Hunter | 2013 | ps3 |
| So Many Me | 2015 | xboxone |
| Soap Panic | 1991 | nes |
| Sofie - Josefines Lillesoester - Syng, Lek og Laer | 2009 | nds |
| Soko Banana | 2024 | nes |
| Soko Banana - Tinsel Island | 2024 | nes |
| Sokoban | | nes |
| Sokoban DS | 2008 | nds |
| Sokoban Next | 2017 | vita |
| Solaris | 2015 | genesis |
| Soldam | 1992 | arcade, gb |
| Soldam: Drop, Connect, Erase | 2017 | ps4, switch |
| Solitaire | 1992 | gb, nes |
| Solitaire Dungeon Escape | 2015 | wiiu |
| Solitaire FunPak | 1994 | gb, gg |
| Solitaire Mahjong - Ancient China Adventure | 2004 | nds |
| Solo: Islands of the Heart | 2019 | xboxone |
| Solomon | 2000 | gbc |
| Solomon no Kagi | 1991 | fds |
| Solomon no Kagi | 1986 | arcade, nes |
| Solomon no Kagi 2 - Coolmintou Kyuushutsu Sakusen | 1992 | nes |
| Solomon's Key | 1986 | arcade, nes |
| Solomon's Key | 2006 | wii |
| Solomon's Key 2 | 1993 | nes |
| Son of the Lion King | 2006 | ps2 |