| DuckTales | 2023 | snes |
| DuckTales - Remastered | 2013 | xbox360 |
| DuckTales 2 | 1991 | gb, nes |
| Duckstroma | 2020 | nes |
| Duke Nukem | 1999 | gbc |
| Dustforce | 2012 | ps3, vita, xbox360 |
| Dye | 2018 | xboxone |
| Dyna Gear | 1993 | arcade |
| Dynamite Bomber | 2000 | arcade |
| Dynamite Headdy | 1994 | genesis, gg, sms |
| Dynowarz - The Destruction of Spondylus | 1990 | nes |
| E-SWAT | 1990 | sms |
| EDGE | 2004 | nds |
| ESWAT - City under Siege | 1990 | genesis, wii |
| EZ-Flash Vi | 2005 | nds |
| EarthNight | 2019 | ps4, switch |
| Earthworm Jim - Special Edition | 1994 | segacd |
| Earthworm Jim 2 | 2002 | gba |
| Earthworm Jim 2 | 1996 | nes |
| Earthworm Jim 2 | 1996 | nes |
| Earthworm Jim 2 | 1996 | ps1, saturn |
| Earthworm Jim 2 | 2009 | wii |
| Earthworm Jim 3 | 1997 | nes |
| Earthworm Jim 3D | 1999 | n64 |
| Earthworm Jim HD | 2010 | ps3 |
| Earthworm Jim HD | 2014 | ps3 |
| Earthworm Jim HD | 2010 | xbox360 |
| Ed, Edd n Eddy - Jawbreakers! | 2002 | gba |
| Ed, Edd n Eddy - The Mis-Edventures | 2005 | gba, gc, ps2, xbox |
| Edd the Duck | 1993 | gb |
| Eeekk! | 1983 | arcade |
| Eekeemoo: Splinters of the Dark Shard | 2017 | xboxone |
| El Estivador | 1982 | arcade |
| Electrician | 1986 | fds |
| Electronic Dreams | 2023 | sms |
| Electronic Super Joy | 2015 | ps4, wiiu |
| Electronic Super Joy | 2016 | xboxone |
| Electronic Super Joy 2 | 2020 | ps4 |
| Element4l | 2015 | vita |
| Elevator Action | 1983 | a2600, arcade, nes, sg1000, wiiu |
| Elevator Action | 1991 | gb |
| Elevator Action - Old & New | 2002 | gba |
| Elevator Action Deluxe | 2011 | ps3 |
| Elevator Action EX | 2000 | gbc |
| Elevator Action II | 1994 | arcade |
| Elevator Action Returns | 1994 | arcade |
| Elevator Action^2 - Returns | 1997 | saturn |
| Elf - The Movie | 2004 | gba |
| Elf Run | 2020 | genesis |
| Elfland | 1993 | nes |
| Embers of Mirrim | 2017 | ps4, xboxone |
| Emerald Shores | 2018 | vita |
| Emma - Lost in Memories | 2020 | vita |
| Emo Cheng DX | | gbc |
| The Emperor's New Groove | 2000 | gbc, ps1 |
| Enchanted | 2004 | nds |
| Enchanted - Once Upon Andalasia | 2007 | gba |
| The End Is Nigh | 2017 | ps4, switch |
| The Energy Thieves | 2004 | ps2 |
| Epic Loon | 2018 | xboxone |
| Epic Mickey: Rebrushed | 2024 | ps4, switch |
| Escape 2042 - The Truth Defenders | 2017 | jaguar |
| Escape Goat 2 | 2014 | ps4 |
| Escape from Mars Starring Taz | 1994 | genesis |
| Espitene | 2017 | nes |
| Espitenen und Herr Pimponen | 2019 | nes |
| Eternal City - Toshi Tensou Keikaku | 1991 | pcengine |
| The Eternal Life of Goldman | 2026 | switch |
| Eternum Ex | 2019 | xboxone |
| Ethan - Meteor Hunter | 2013 | ps3, vita |
| Ethan: Meteor Hunter | 2016 | xboxone |
| Etherborn | 2019 | ps4, xboxone |
| Evergate | 2020 | ps4, switch, xboxone |
| Evil Twin - Cyprien's Chronicles | 2001 | dreamcast, ps2 |
| Ex-Mutants | 1992 | genesis |
| Exception | 2019 | ps4, switch, xboxone |
| Exile's End | 2016 | ps4, vita, wiiu, xboxone |
| Exo Squad | 1995 | genesis |
| Expiration Date | 2022 | gbc |
| Explodemon | 2011 | ps3 |
| The Exploits of Fingers Malone | 2022 | gbc |
| Express Raider | 1986 | arcade |
| Extreme Exorcism | 2015 | ps3, wiiu, xboxone |
| Extreme Ghostbusters | 2001 | gbc |
| Extreme Ghostbusters - Code Ecto-1 | 2002 | gba |
| FC Genjin - Freakthoropus Computerus | 1993 | nes |
| FX Unit Yuki | 2019 | dreamcast |
| FX Unit Yuki - The Henshin Engine | 2018 | pcengine |
| The Fairly OddParents - Breakin' da Rules | 2003 | gba, gc, ps2, xbox |
| The Fairly OddParents! - Clash with the Anti-World | 2005 | gba |
| The Fairly OddParents! - Enter the Cleft | 2002 | gba |
| A Fairy Without Wings | 2019 | gb |
| The FairyLand Story | 1985 | arcade, nes |
| Fall Down | 2005 | a2600 |
| Famicom Mini 08 - Mappy | 2004 | gba |
| Famicom Mini 11 - Mario Bros | 2004 | gba |
| Famicom Mini 14 - Wrecking Crew | 2004 | gba |
| Famicom Mini 17 - Takahashi Meijin no Bouken-jima | 2004 | gba |
| Famicom Mini 21 - Super Mario Bros. 2 | 2004 | gba |
| Famicom Remix Best Choice | 2015 | 3ds |