| Speed Ball | 1987 | arcade |
| Speed Limit | 2021 | ps4, xboxone |
| Speedball 2 | 1992 | genesis |
| Speedball 2 - Brutal Deluxe | 1991 | genesis |
| Speedball 2100 | 2000 | ps1 |
| Speedway + Spin-out + Crypto-logic | 1978 | o2 |
| Speedy Gonzales - Los Gatos Bandidos | 1995 | snes |
| Speedy Gonzales in Los Gatos Bandidos | 1994 | snes |
| Spellcaster's Assistant | 2018 | wiiu |
| Spider-Man | 2006 | o2 |
| Spider-Man | 1990 | sms |
| Spider-Man - Allie ou Ennemi | 2004 | nds |
| Spider-Man - Amici o Nemici | 2004 | nds |
| Spider-Man - Amigo o Enemigo | 2004 | nds |
| Spider-Man - Freund oder Feind | 2004 | nds |
| Spider-Man 2 - Enter - Electro | 2001 | ps1 |
| Spider-Man 3 - Movie Version | 2004 | gbc |
| Spider-Man and the X-Men in Arcade's Revenge | 1992 | snes |
| Spiderman 2 | 2004 | nes |
| Spiders | 1982 | a2600, arcadia |
| Spike's Peak | 1983 | a2600 |
| Spin Master | 2010 | wii |
| Spinball | 1983 | vectrex |
| Spindizzy Worlds | 1992 | snes |
| Spinning Fireball | 1983 | a2600 |
| Spirit - Stallion of the Cimarron - Search for Homeland | 2002 | gba |
| Spirit Impel | 2021 | nes |
| Spitfire Attack | 1983 | a2600 |
| Splash Lake - Ostrich Daibouken | 1991 | pcengine |
| Splatterhouse ) | 1988 | arcade, pcengine |
| Splatterhouse 2 | 1992 | genesis |
| Splatterhouse 2 | 2008 | wii |
| Splatterhouse Part 2 | 1992 | genesis |
| SpongeBob SquarePants - Plankton's Robotic Revenge | 2013 | 3ds, nds, ps3, wiiu |
| SpongeBob SquarePants - The Yellow Avenger | 2005 | nds, psp |
| SpongeBob SquarePants Featuring Nicktoons - Globs of Doom | 2008 | nds |
| SpongeBob SquigglePants | | 3ds |
| SpongeBob SquigglePants 3D | 2011 | 3ds |
| Spore - Kimi ga Tsukuru Hero | 2010 | nds |
| Sport Goofy | 1983 | a5200 |
| Sportsfriends | 2014 | ps3, ps4 |
| Spot Goes to Hollywood | 1995 | genesis, ps1, saturn |
| Spout GBA | 2006 | gba |
| Spriggan - Lunar Verse | 1999 | ps1 |
| Springboard | 1977 | arcade |
| Spy Fiction | 2003 | ps2 |
| Spy vs Spy | 1999 | gbc |
| Spy vs Spy - Operation Boobytrap | 1997 | gb |
| Spy vs Spy - Operation Boobytrap | 1992 | gb |
| Spy vs. Spy | 2005 | ps2, xbox |
| SpyHunter 2 | 2003 | ps2, xbox |
| Spyborgs | 2009 | wii |
| Spyro - Year of the Dragon | 2000 | ps1 |
| Spyro 2 - Gateway to Glimmer | 1999 | ps1 |
| Spyro 2 - Ripto's Rage! | 1999 | ps1 |
| Spyro the Dragon | 1998 | ps1 |
| Spyro x Sparx - Tondemo Tours | 2000 | ps1 |
| Square's Preview | 1996 | ps1 |
| Square's Preview 5 | 1999 | ps1 |
| Squaresoft on PlayStation 1998 Collector's CD Vol. 2 | 1998 | ps1 |
| Squeeze Box | 1983 | a2600 |
| Squirrel King | 1995 | genesis |
| Squish'em Featuring Sam | 1984 | col |
| Squoosh | 1983 | a2600 |
| Sssnake | 1982 | a2600 |
| Stahlfeder - Tekkou Hikuudan | 1996 | ps1 |
| Stampede | 1981 | a2600, intv |
| Star Catcher | 2024 | gb |
| Star Chess | 1982 | arcadia |
| Star Driver - Kagayaki no Takuto - Ginga Bishounen Densetsu | 2011 | psp |
| Star Fox | 1983 | a2600 |
| Star Fox 64 | 1997 | n64 |
| Star Fox 64 3D | 2011 | 3ds |
| Star Fox Guard | 2016 | wiiu |
| Star Ixiom | 1999 | ps1 |
| Star Ship ~ Outer Space | 1977 | a2600 |
| Star Splash - Shattered Star | 2017 | wiiu |
| Star Strike | 1981 | a2600, intv |
| Star Trek | 1982 | arcade |
| Star Trek - Invasion | 2000 | ps1 |
| Star Trek - Shattered Universe | 2004 | ps2, xbox |
| Star Trek - Strategic Operations Simulator | 1983 | a2600, a5200, col |
| Star Trek - Tactical Assault | 2006 | nds, psp |
| Star Voyager | 1982 | a2600 |
| Star Wars - Battlefront | 2004 | ps2, xbox |
| Star Wars - Bounty Hunter | 2002 | gc, ps2 |
| Star Wars - Demolition | 2000 | dreamcast, ps1 |
| Star Wars - Episode I - Die dunkle Bedrohung | 1999 | ps1 |
| Star Wars - Episode I - Jedi Power Battles | 2000 | dreamcast, ps1 |
| Star Wars - Episode I - La Menace Fantome | 1999 | ps1 |
| Star Wars - Episode I - The Phantom Menace | 1999 | ps1 |
| Star Wars - Episode III - Die Rache der Sith | 2005 | ps2 |
| Star Wars - Episode III - La Revanche des Sith | 2005 | ps2 |
| Star Wars - Episode III - Revenge of the Sith | 2005 | gba, nds, ps2, xbox |
| Star Wars - Episode III - Sith no Fukushuu | 2005 | ps2 |
| Star Wars - Episodio I - Jedi Power Battles | 2000 | ps1 |
| Star Wars - Episodio I - La Amenaza Fantasma | 1999 | ps1 |
| Star Wars - Episodio I - La Minaccia Fantasma | 1999 | ps1 |
| Star Wars - Jango Fett | 2004 | ps2 |
| Star Wars - Jedi Arena | 1983 | a2600 |