| Solar War | 1979 | arcade |
| SolarStriker | 1990 | gb |
| Solaris | 1986 | a2600 |
| Solomon no Kagi | 2014 | wii |
| Solomon's Club | 1991 | gb |
| Solstice Chronicles: MIA | 2019 | switch |
| Sonata | 1999 | ps1 |
| Sonic 3 | 1994 | genesis |
| Sonic Battle | 2003 | gba |
| Sonic Blast Man II | 1994 | snes |
| Sonic Chaos | 2009 | wii |
| Sonic Drift | 1994 | gg |
| Sonic Gems Collection | 2005 | gc, ps2 |
| Sonic Labyrinth | 1995 | gg |
| Sonic Mega Collection Plus | 2004 | ps2, xbox |
| Sonic Pinball Party | 2003 | gba |
| Sonic Spinball | 1993 | genesis, gg, sms |
| Sonic Spinball | 2007 | wii |
| Sonic The Hedgehog | 1991 | arcade, genesis |
| Sonic The Hedgehog 2 | 1992 | gg, sms |
| Sonic The Hedgehog 2 | 2008 | wii |
| Sonic The Hedgehog 3 | 1994 | genesis |
| Sonny X'Press | 1992 | svision |
| Sorcerer | 1983 | a2600 |
| Sorcerer's Apprentice | 1983 | a2600 |
| Sorcerer's Maze | 2003 | ps1 |
| Sorcerous Stabber Orphen | 2002 | ps2 |
| Soreike! Anpanman - 5-tsu no Tou no Ousama | 2000 | gbc |
| Sougou Kakutougi - Astral Bout | 1992 | snes |
| Soukaigi | 1998 | ps1 |
| Soukoban Densetsu - Hikari to Yami no Kuni | 1999 | gbc |
| Soukou Kidoutai L.A.P.D | 1999 | ps1 |
| Soukou Kihei Votoms | 2007 | ps2 |
| Soukou Kihei Votoms - Lightning Slash | 1999 | ps1 |
| Soukou Kihei Votoms - The Battling Road | 1993 | snes |
| Soukou Kihei Votoms - Woodo Kummen | 1998 | ps1 |
| Soukou Kihei Votoms Gaiden - Ao no Kishi Berserga Monogatari | 1997 | ps1 |
| Soukyuu Gurentai - Oubu Shutsugeki | 1998 | ps1 |
| Soukyuu no Fafner | | psp |
| Soul Eater - Medusa no Inbou | 2008 | nds |
| Soul Reaver 2 | 2001 | ps2 |
| Soul of the Samurai | 1999 | ps1 |
| Soumatou | 1999 | ps1 |
| A Sound of Thunder | 2004 | gba |
| Sousei no Aquarion | 2005 | ps2 |
| South Park: Snow Day! | 2024 | switch |
| Soviet Strike | 1996 | ps1, saturn |
| Space Ace | 1994 | 3do, jaguarcd, segacd |
| Space Ace | 1994 | cdi, snes |
| Space Adventure Cobra - The Shooting | 1996 | ps1 |
| Space Armada | 1981 | intv |
| Space Attack | 1982 | arcadia |
| Space Battle | 1979 | intv |
| Space Bazooka | 1993 | snes |
| Space Camp | 2009 | nds, wii |
| Space Cavern | 1982 | a2600 |
| Space Chaser | 1979 | arcade |
| Space Date | 1992 | gb |
| Space Debris | 2000 | ps1 |
| Space Dungeon | 1983 | a5200 |
| Space Fury | 1981 | arcade, col |
| Space Griffon VF-9 | 1995 | ps1 |
| Space Gun | 1992 | sms |
| Space Hawk | 1981 | intv |
| Space Hunter | 1986 | nes |
| Space Invaders 2000 | 1998 | ps1 |
| Space Jockey | 1982 | a2600 |
| Space Marauder | 2000 | gbc |
| Space Micon Kit | 1978 | arcade |
| Space Panic | 1980 | arcade, col |
| Space Pinball | 1995 | vb |
| Space Raiders | 1982 | arcadia |
| Space Rebellion | 2006 | ps2 |
| Space Slalom | 1983 | sg1000 |
| Space Squadron | 1982 | arcadia |
| Space Vultures | 1982 | arcadia |
| Space Walk | 1978 | arcade |
| Space War | 1978 | a2600 |
| Spacechase | 1982 | a2600 |
| Spaceship Game for Kids | 2010 | xbox360 |
| Spark World | 1995 | snes |
| Sparkle 2 Evo | 2017 | switch |
| Sparkle 3 Genesis | 2018 | switch |
| Sparkster | 1994 | genesis, snes |
| Sparkster - Rocket Knight Adventures 2 | 1994 | genesis |
| Spartan - Kodai Greece Eiyuuden | 2005 | ps2 |
| Spartan - Total Warrior | 2005 | gc, ps2, xbox |
| Spatter | 1984 | arcade |
| Spawn - Armageddon | 2003 | gc, ps2, xbox |
| Spawn - The Eternal | 1997 | ps1 |
| Spawn - Unmei no Kusari | 2003 | ps2 |
| Spawn: In the Demon's Hand | 1999 | arcade, dreamcast |
| Spec Ops - Airborne Commando | 2002 | ps1 |
| Spec Ops - Covert Assault | 2001 | ps1 |
| Spec Ops - Ranger Elite | 2001 | ps1 |
| Spec Ops - Stealth Patrol | 2000 | ps1 |
| Spec Ops - The Line | 2012 | ps3, xbox360 |
| Spectar | 1980 | arcade |
| Spectar | 1984 | arcade |
| Speed Ball | 2020 | genesis |