| Sega Ages 2500 Series Vol. 4 - Space Harrier | 2003 | ps2 |
| Sega Ages 2500 Series Vol. 5 - Golden Axe | 2003 | ps2 |
| Sega Ages 2500 Series Vol. 6 - Ichini no Tant-R to Bonanza Bros | 2004 | ps2 |
| Sega Classics Collection | 2005 | ps2 |
| Sega Flipper | 1983 | sg1000 |
| Seigi no Mikata | 2001 | ps2 |
| Seiken Densetsu - Legend of Mana | 1999 | ps1 |
| Seiken Densetsu 4 | 2007 | ps2 |
| Seishoujo Kantai Virgin Fleet | 1999 | ps1 |
| Seishun Scandal | 1986 | sms |
| Sekai de Ichiban NG na Koi - Full House | 2011 | psp |
| Sekhmet's Playground | 2024 | gba |
| Sel Feena | 1991 | arcade |
| Sengoku 2 | 2012 | wii |
| Sengoku 3 | 2013 | wii |
| Sengoku Basara | 2005 | ps2 |
| Sengoku Basara - Battle Heroes | 2009 | psp |
| Sengoku Basara - Chronicle Heroes | 2011 | psp |
| Sengoku Basara - Samurai Heroes | 2010 | ps3, wii |
| Sengoku Basara - Sanada Yukimura-den | 2016 | ps3 |
| Sengoku Basara 2 | 2006 | ps2, ps3 |
| Sengoku Basara 3 | 2010 | ps3 |
| Sengoku Basara 4 | 2014 | ps3, ps4 |
| Sengoku Basara 4 - Sumeragi | 2015 | ps3 |
| Sengoku Denshou 2001 | | wii |
| Sengoku Musou | 2004 | ps2 |
| Sengoku Musou - Moushouden | 2004 | ps2 |
| Sengoku Musou 2 | 2006 | ps2 |
| Sengoku Musou 2 - Empires | 2006 | ps2 |
| Sengoku Musou 2 - Moushouden | 2007 | ps2 |
| Sengoku Musou 2 Empires HD Version | 2013 | vita |
| Sengoku Musou 2 with Moushouden HD Version | 2013 | ps3, vita |
| Sengoku Musou 3 Z Special | 2012 | psp |
| Sengoku Musou Chronicle | 2013 | 3ds |
| Senkai Taisen - TV Animation Senkaiden Houshin Engi yori | 2000 | ps1 |
| Senran Kagura 2 - Deep Crimson | 2015 | 3ds |
| Senran Kagura 2 - Shinku | 2014 | 3ds |
| Senran Kagura Burst | 2013 | 3ds |
| Senran Kagura Burst Re:Newal | 2018 | ps4 |
| Senran Kagura: Estival Versus | 2015 | ps4, vita |
| Senran Kagura: Peach Ball | 2018 | switch |
| Senran Kagura: Peach Beach Splash | 2017 | ps4 |
| Sentinel | 1990 | a2600, a7800 |
| Sentinel Returns | 1998 | ps1 |
| Sentouin Yamada Hajime | 2004 | gba |
| Septentrion - Out of the Blue | 1999 | ps1 |
| Serpent | 1990 | gb |
| Serpentine | 2016 | a7800 |
| Sesam Offne Dich! | 1983 | a2600 |
| Seven Samurai 20XX | 2004 | ps2 |
| Sewer Sam | 1983 | col, intv |
| Shackled | 1986 | arcade |
| Shadow Archer Special | | wiiu |
| Shadow Archery | 2018 | wiiu |
| Shadow Blasters | 1990 | genesis |
| Shadow Corridor | 2019 | ps4, switch |
| Shadow Dancer | 1991 | sms |
| Shadow Gunner - The Robot Wars | 1998 | ps1 |
| Shadow Man | 1999 | dreamcast, n64, ps1 |
| Shadow Man - Rette deine Seele | 2000 | ps1 |
| Shadow Master | 1997 | ps1 |
| Shadow Warriors II - Ninja Gaiden II | 1990 | nes |
| Shadow of Memories | 2001 | ps2 |
| Shadow of Rome | 2005 | ps2 |
| The Shadow of Zorro | 2002 | ps2 |
| Shadow of the Beast | 2016 | ps4 |
| Shadow of the Beast | 1991 | sms |
| Shadow of the Colossus | 2005 | ps2 |
| Shadow of the Ninja | 2010 | wii |
| Shadow the Hedgehog | 2005 | gc, ps2, xbox |
| Shake Kids | 1998 | ps1 |
| Shake Spears! | 2014 | ps3 |
| Shake Spears! | 2014 | vita |
| Shaman King - Funbari Spirits | 2004 | ps2 |
| Shaman King Card Game - Chou Senjiryakketsu - Funbari Hen | 2000 | gbc |
| Shaman King Card Game - Chou Senjiryakketsu - Meramera Hen | 2001 | gbc |
| Shaolin | 2000 | ps1 |
| Shark Hunter | 2006 | o2 |
| Shark JAWS | 1975 | arcade |
| Shark! Shark! | 1982 | intv |
| Shatter | 2009 | ps3 |
| Shattering Jaws | 2016 | genesis |
| Sheep | 2000 | gba, ps1 |
| Sheep, Dog 'n' Wolf | 2001 | ps1 |
| Shellshock | 1995 | ps1, saturn |
| Shellshock - Jus' Keepin' da Peace | 1996 | ps1, saturn |
| Sherlock Holmes - Hakushaku Reijou Yuukai Jiken | 1986 | nes |
| Shichisei Toushin Guyferd - Crown Kaimetsu Sakusen | 1998 | ps1 |
| Shien - The Blade Chaser | 1994 | snes |
| Shien's Revenge | 1994 | snes |
| Shikihime no Niwa | 2018 | vita |
| Shin Contra | 2002 | ps2 |
| Shin Gundam Musou | | ps3 |
| Shin Gundam Musou | 2013 | vita |
| Shin Hokuto Musou | 2013 | wiiu |
| Shin Jidaigeki Action - Rasetsu no Ken | 1999 | ps1 |
| Shin Megami Tensei - Lucifer's Call | 2005 | ps2 |
| Shin Megami Tensei - Nocturne | 2004 | ps2 |
| Shin Megami Tensei III - Nocturne | 2003 | ps2 |
| Shin Megami Tensei III - Nocturne Maniax | 2004 | ps2 |