| Sadame | 2016 | 3ds |
| Safari Rally | 1979 | arcade |
| Safecracker | 1983 | intv |
| Saigo no Nindou | 1993 | gb |
| Sailor Fuku Bishoujo Zukan Vol. 1 | 1989 | fds |
| Sailor Fuku Bishoujo Zukan Vol. 2 | 1989 | fds |
| Sailor Fuku Bishoujo Zukan Vol. 3 | 1989 | fds |
| Sailor Fuku Bishoujo Zukan Vol. 4 | 1989 | fds |
| Sailor Fuku Bishoujo Zukan Vol. 5 | 1989 | fds |
| Sailor Fuku Bishoujo Zukan Vol. 6 | 1989 | fds |
| Saints Row IV - Game of the Century Edition | 2014 | ps3 |
| Saints Row IV: Re-Elected | 2020 | switch |
| Saiyuuki World | 1988 | nes |
| Sakigake!! Cromartie Koukou - Kore wa Hyotto Shite Game Nano ka! Hen | 2004 | ps2 |
| Sakigake!! Otoko Juku - Meioutou Kessen | 1990 | gb |
| Sakigake!! Otokojuku - Nihon yo, Kore ga Otoko de Aru! | 2014 | ps3 |
| Sakura Samurai - Art of the Sword | 2012 | 3ds |
| Sakura Taisen V Episode 0 - Kouya no Samurai Musume | 2004 | ps2 |
| Sakurazaka Shouboutai | 2004 | ps2 |
| Same! Same! Same! | 1989 | arcade, genesis |
| Sammy Lightfoot | 1983 | col |
| Samurai | 2002 | ps2 |
| Samurai Champloo | 2006 | ps2 |
| Samurai Champloo - Sidetracked | 2006 | ps2 |
| Samurai G | 2012 | 3ds |
| Samurai Ghost | 2007 | wii |
| Samurai Jack - The Shadow of Aku | 2004 | gc, ps2 |
| Samurai Kanzenban | 2003 | ps2 |
| Samurai Kid | 2001 | gbc |
| Samurai Warriors | 2004 | ps2, xbox |
| Samurai Warriors - Chronicles 3 | 2014 | 3ds, vita |
| Samurai Warriors - State of War | 2006 | psp |
| Samurai Warriors - Xtreme Legends | 2004 | ps2 |
| Samurai Warriors 2 | 2006 | ps2, ps3, xbox360 |
| Samurai Warriors 2 - Empires | 2006 | ps2, xbox360 |
| Samurai Warriors 2 - Xtreme Legends | 2007 | ps2 |
| Samurai Warriors 4 | 2014 | ps3, ps4, vita |
| Samurai Warriors 4: Empires | 2015 | ps3, ps4, vita |
| Samurai Warriors 5 | 2021 | ps4, switch, xboxone |
| Samurai Warriors: Spirit of Sanada | 2016 | ps4, switch |
| Samurai Western | 2005 | ps2 |
| Samurai Western - Katsugeki Samurai-dou | 2005 | ps2 |
| San Guo Zhi Lie Zhuan - Luan Shi Qun Ying | 1991 | genesis |
| San-X Character Sagashi Land | 2007 | nds |
| Sangokushi II | 1990 | genesis, nes |
| A Sangre Fria | 2000 | ps1 |
| A Sangue Freddo | 2000 | ps1 |
| Sanguo Yanyi - Huoshao Chibi | | genesis |
| Sanguozhi - Chibi Zhi Zhan | 1993 | nes |
| Sanrin San Chan | 1984 | arcade |
| Sanrin San-chan - Spatter | 2022 | genesis |
| Sanrio World Smash Ball! | 1993 | snes |
| Santa Claus Junior | 2001 | gbc |
| Santa's Empty Sack | 2020 | lynx |
| Sanvein | 2000 | ps1 |
| Sapo Xule - O Mestre do Kung Fu | 1995 | sms |
| Sapo Xule - S.O.S. Lagoa Poluida | 1995 | sms |
| Saraba Uchuu Senkan Yamato - Ai no Senshitachi | 2000 | ps1 |
| Saru! Get You! | 1999 | ps1 |
| Saru! Get You! 2 | 2002 | ps2 |
| Saru! Get You! 3 | 2005 | ps2 |
| Saru-Kani-Hamu-Zou | 1997 | arcade |
| Saturn Bomberman | 1996 | saturn |
| Saturn Bomberman Fight!! | 1997 | saturn |
| Savanna | 1982 | arcade |
| Save Mary! | 1989 | a2600 |
| Save Our Ship | 1983 | a2600 |
| Save the Whales | 1983 | a2600 |
| Sawaru Made in Wario | 2004 | nds |
| Sawaru Made in Wario | 2015 | wiiu |
| Sayonara Umihara Kawase | 2013 | 3ds |
| Scared Rider Xechs I+FD Portable | 2012 | psp |
| Scarfinger | 1982 | intv |
| Scooby Doo's Maze Chase | 1983 | intv |
| Scooby-Doo and the Cyber Chase | 2001 | ps1 |
| Scooby-Doo et la Cybertraque | 2001 | ps1 |
| Scooby-Doo! Nacht der 100 Schrecken | 2002 | ps2 |
| Scooby-Doo! and the Spooky Swamp | 2004 | nds, ps2, wii |
| Scrambled Egg | 1983 | arcade |
| Scud Hammer | 1994 | arcade |
| Sea Devil | 1983 | astrocade |
| Sea Monster | 1983 | a2600 |
| Seaquest | 1983 | a2600 |
| Seasonal Assistant | | wiiu |
| Secret Agent | 1983 | a2600 |
| Secret Quest | 1989 | a2600 |
| The Secret Saturdays - Beasts of the 5th Sun | 2009 | nds, ps2, psp, wii |
| Secret Weapons over Normandy | 2003 | ps2, xbox |
| Sector Alpha | 1983 | col |
| See Saw | 1983 | a2600 |
| The Seed | | ps2 |
| Sega Ages 2500 Series Vol. 10 - After Burner II | 2004 | ps2 |
| Sega Ages 2500 Series Vol. 11 - Hokuto no Ken | 2004 | ps2 |
| Sega Ages 2500 Series Vol. 14 - Alien Syndrome | 2004 | ps2 |
| Sega Ages 2500 Series Vol. 23 - Sega Memorial Selection | 2005 | ps2 |
| Sega Ages 2500 Series Vol. 26 - Dynamite Deka | 2006 | ps2 |
| Sega Ages 2500 Series Vol. 27 - Panzer Dragoon | 2006 | ps2 |
| Sega Ages 2500 Series Vol. 3 - Fantasy Zone | 2003 | ps2 |
| Sega Ages 2500 Series Vol. 30 - Galaxy Force II - Special Extended Edition | 2007 | ps2 |
| Sega Ages 2500 Series Vol. 31 - Dennou Senki - Virtual On | 2007 | ps2 |