| Squaresoft on PlayStation 1998 Collector's CD Vol. 1 | 2000 | ps1 |
| Squinkies - Surprize Inside | 2011 | nds |
| Star Balls | 2017 | xboxone |
| Star Fox Adventures | 2002 | gc |
| Star Raiders | 2011 | ps3, xbox360 |
| Star Wars - Caballeros de la Antigua Republica II - Los Senores Sith | 2004 | xbox |
| Star Wars - Lethal Alliance | 2006 | nds, psp |
| Star Wars - Obi-Wan | 2001 | xbox |
| Star Wars - The Clone Wars - Jedi Alliance | 2008 | nds |
| Star Wars - The Clone Wars - Republic Heroes | 2009 | nds, ps2, ps3, psp, wii, xbox360 |
| Star Wars - The Force Unleashed II | 2006 | nds, ps3, wii, xbox360 |
| Star Wars Jedi: Fallen Order | 2019 | ps4, xboxone |
| Star Wars Jedi: Survivor | 2024 | ps4 |
| Star Wars Knights of the Old Republic II: The Sith Lords | 2022 | switch |
| StarTropics | 2016 | wiiu |
| Starlink: Battle for Atlas | 2018 | ps4, switch, xboxone |
| The Starship Damrey | 2013 | 3ds |
| State of Decay | 2013 | xbox360 |
| State of Decay 2 | 2018 | xboxone |
| State of Decay: Year One Survival Edition | 2015 | xboxone |
| Stealth Inc 2: A Game of Clones | 2014 | ps3, ps4, vita, wiiu, xboxone |
| Stealth Inc. - A Clone in the Dark | 2013 | ps3, ps4, vita |
| Stealth Inc. - A Clone in the Dark - Ultimate Edition | 2016 | vita |
| SteamWorld Dig HD | 2014 | wiiu |
| Steambot Chronicles | 2005 | ps2 |
| Steel Lords | 2016 | wiiu |
| Steel Rivals | 2016 | wiiu |
| Sternentaenzer - Das Geheimnisvolle Pferd | 2009 | nds |
| Steven Universe: Unleash the Light | 2021 | switch |
| Stolen | 2005 | ps2, xbox |
| The Stone of Madness | 2025 | switch |
| Stories of Bethem: Full Moon | 2016 | xboxone |
| The Story Goes On | 2018 | xboxone |
| The Story of Thor | 2007 | wii |
| The Story of Thor 2 | 1996 | saturn |
| Stranded Deep | 2020 | ps4, xboxone |
| Stranger Things 3: The Game | 2019 | ps4, switch, xboxone |
| Streets of Rage 2 | 2007 | wii |
| Streets of Rage 3 | 2007 | wii |
| Strider | 2014 | ps3, ps4, xbox360, xboxone |
| Stuntman | 2002 | gba, ps2 |
| Styx: Master of Shadows | 2014 | ps4, xboxone |
| Styx: Shards of Darkness | 2017 | ps4, xboxone |
| Subnautica | 2018 | ps4, switch, xboxone |
| Subnautica: Below Zero | 2021 | ps4, switch |
| Subterrain | 2017 | ps4, xboxone |
| The Suffering | 2004 | ps2, xbox |
| The Suite Life of Zack & Cody - Circle of Spies | 2007 | nds |
| Sundered | 2017 | ps4 |
| Sundered: Eldritch Edition | 2018 | xboxone |
| Sunset Overdrive | 2014 | xboxone |
| Sunshower | 2025 | switch, xboxone |
| Super Castlevania IV | 2013 | wiiu |
| Super Hydorah | 2017 | xboxone |
| Super Mad Max | 1990 | nes |
| Super Mario 64 DS | 2016 | wiiu |
| Super Mario Advance | 2016 | wiiu |
| Super Mario Advance 4 - Super Mario Bros. 3 | 2016 | wiiu |
| Super Mario Bros | 2013 | wiiu |
| Super Mario Bros. - The Lost Levels | 2014 | wiiu |
| Super Mario Bros. 2 | 2013 | wiiu |
| Super Mario Bros. 3 | 2014 | wiiu |
| Super Mario Galaxy | 2015 | wiiu |
| Super Mario RPG - Legend of the Seven Stars | 2016 | wiiu |
| Super Mario World - Super Mario Advance 2 | 2014 | wiiu |
| Super Pokemon Rumble | 2012 | 3ds |
| Super Pokemon Scramble | 2013 | 3ds |
| Super Robo Mouse | 2016 | wiiu |
| Super Turrican | 2008 | wii |
| Super Turrican 2 | 2008 | wii |
| SuperEpic: The Entertainment War | 2019 | ps4, xboxone |
| Superman - Shadow of Apokolips | 2002 | gc, ps2 |
| Superman - The Man of Steel | 2002 | xbox |
| Surfin' Sam - Attack of the Aqualites | 2016 | wiiu |
| The Survivalists | 2020 | ps4, switch |
| The Swindle | 2015 | ps3, ps4, switch, vita, wiiu, xboxone |
| Switchball | 2007 | xbox360 |
| The Sword of Etheria | 2005 | ps2 |
| Sword of the Berserk - Guts' Rage | 2000 | dreamcast |
| Swords of Destiny | 2005 | ps2 |
| Sylvio | 2017 | xboxone |
| Symmetry | 2018 | xboxone |
| Syndrome | 2017 | xboxone |
| Syphon Filter 3 - Sentencia Final | 2001 | ps1 |
| TRON - Evolution | 2004 | nds |
| Tails of Iron | 2021 | switch |
| Takt of Magic | 2009 | wii |
| Tangled | 2011 | nds |
| Tanzia | 2018 | switch |
| Tasomachi: Behind the Twilight | 2022 | ps4, switch |
| Taz - Wanted | 2002 | gc, ps2, xbox |
| Tchia | 2023 | ps4, switch |
| Team Innocent - The Point of No Return - G.C.P.O.SS | 1994 | pcfx |
| Teenage Mutant Ninja Turtles | 2013 | 3ds, wii |
| Teenage Mutant Ninja Turtles | 2003 | gba, gc, nds, ps2, psp, wii, xbox, xbox360 |
| Teenage Mutant Ninja Turtles - Danger of the Ooze | 2014 | 3ds, ps3 |
| Teenage Mutant Ninja Turtles - Master Splinter's Training Pack | 2015 | 3ds |
| Teenage Mutant Ninja Turtles - Mutants in Manhattan | 2016 | ps3, ps4, xbox360, xboxone |
| Teenage Mutant Ninja Turtles - Smash-Up | 2009 | ps2, wii |
| Tenchu - Dark Secret | 2006 | nds |