| Shrek le Troisieme | 2007 | nds |
| Shuttle Rush | 2014 | wiiu |
| Signalis | 2022 | switch |
| Silent Hill | 1999 | ps1 |
| Silent Hill - Downpour | 2012 | ps3, xbox360 |
| Silent Hill - HD Collection | 2012 | ps3, xbox360 |
| Silent Hill - Homecoming | 2008 | ps3, xbox360 |
| Silent Hill - Origins | 2007 | ps2, psp |
| Silent Hill - Shattered Memories | 2009 | ps2, psp, wii |
| Silent Hill 2 - Inner Fears | 2001 | xbox |
| Silent Hill 2 - Saigo no Uta | 2001 | xbox |
| Simple 2000 Series Vol. 113 - The Tairyou Jigoku | 2007 | ps2 |
| Simple DS Series Vol. 46 - The Hikyou Tankentai - Choujou Special 'Kyoui! Jinrui Mitou no Sekai Kakuchi ni Nazo no Mikakunin Seibutsu wa Sonzai Shita!!' | 2009 | nds |
| Sinister Assistant | 2019 | wiiu |
| The Sinking City | 2019 | ps4, switch, xboxone |
| Siren | 2003 | ps2 |
| Siren - Blood Curse | 2008 | ps3 |
| Siren - New Translation | 2008 | ps3 |
| Siren 2 | 2006 | ps2 |
| Skellboy | 2020 | switch |
| Skull and Bones | 2022 | xboxone |
| SkyDrift | 2011 | ps3, xbox360 |
| SkyKid | 2015 | wiiu |
| Skylanders - Spyro's Adventure | 2011 | 3ds, ps3, wii, xbox360 |
| Skylanders Trap Team | 2014 | 3ds, ps4, wii, wiiu, xboxone |
| Skyling: Garden Defense | 2016 | xboxone |
| Sleeping Dogs | 2012 | ps3, xbox360 |
| Sleeping Dogs: Definitive Edition | 2014 | ps4, xboxone |
| Slender - The Arrival | 2014 | ps3, ps4, switch, wiiu, xbox360, xboxone |
| Slime Morimori Dragon Quest - Shougeki no Shippo Dan | 2003 | gba |
| Slime Rancher | 2017 | ps4, xboxone |
| Slitterhead | 2024 | ps4 |
| Sly Cooper - Thieves in Time | 2013 | ps3, vita |
| Sly Cooper and the Thievius Raccoonus | 2011 | ps3 |
| Sly Cooper and the Thievius Raccoonus | 2014 | vita |
| The Smurfs 2 | 2013 | nds, ps3, wii, wiiu, xbox360 |
| The Smurfs Collection | 2014 | nds |
| The Smurfs: Mission Vileaf | 2021 | ps4, switch, xboxone |
| Sneak King | 2006 | xbox |
| Solar Ash | 2021 | ps4 |
| Solar Shifter EX | 2016 | xboxone |
| Solatorobo - Red the Hunter | 2010 | nds |
| The Solus Project | 2016 | ps4, xboxone |
| Soma | 2015 | ps4 |
| Soma | 2017 | xboxone |
| Song of Horror | 2021 | ps4, xboxone |
| Song of the Deep | 2016 | ps4 |
| Sonic 3D Blast | 2007 | wii |
| Sonic Adventure 2 - The Trial | 2000 | dreamcast |
| Sonic Adventure DX - Director's Cut | 2003 | gc |
| Sonic Boom - Fire & Ice | 2016 | 3ds |
| Sonic Boom - Rise of Lyric | 2014 | wiiu |
| Sonic Generations - Ao no Bouken | 2013 | 3ds |
| Sonic Lost World | 2013 | 3ds, wiiu |
| Sonic X Shadow Generations | 2024 | switch |
| Sonic and the Black Knight | 2009 | wii |
| Sonic and the Secret Rings | 2007 | wii |
| The Sopranos - Road to Respect | 2006 | ps2 |
| Sorcery | 2012 | ps3 |
| Soul Eater - Monotone Princess | 2008 | wii |
| Soulcalibur | 2008 | xbox360 |
| Soulcalibur Legends | 2007 | wii |
| Souldiers | 2022 | switch |
| Sousei no Onmyouji | 2017 | vita |
| Space Giraffe | 2007 | xbox360 |
| Spacelords | 2017 | xboxone |
| Special Forces | 2006 | ps2 |
| Spectrobes - Origins | 2009 | wii |
| Spectrum | 2018 | xboxone |
| Spelunker | 2008 | wii |
| Spelunker Party! | 2017 | switch |
| Spelunky | 2021 | switch |
| SphereZor | 2016 | wiiu |
| Sphinx and the Cursed Mummy | 2003 | gc, ps2, switch, xbox |
| Spider-Man | 1982 | a2600 |
| Spider-Man | 2000 | dreamcast, gba, gbc, gc, n64, ps1, ps2, xbox |
| Spider-Man - Edge of Time | 2011 | 3ds, nds, ps3, wii, xbox360 |
| Spider-Man - Edge of Time | 2006 | ps3 |
| Spider-Man - Friend or Foe | 2007 | nds, ps2, psp, wii, xbox360 |
| Spider-Man - Shattered Dimensions | 2004 | nds |
| Spider-Man - Shattered Dimensions | 2010 | ps3, xbox360 |
| Spider-Man - Shattered Dimensions | 2010 | wii |
| Spider-Man - Web of Shadows | 2008 | nds, ps3, psp, wii, xbox360 |
| Spider-Man 2 | 2004 | gba, gc, nds, ps2, psp, xbox |
| Spider-Man 3 | 2007 | gba, nds, ps2, ps3, psp, wii, xbox360 |
| Spider-Man vs The Kingpin | 1991 | arcade, genesis, segacd |
| Spider-Man: Miles Morales | 2020 | ps4 |
| The Spiderwick Chronicles | 2008 | nds, ps2, wii, xbox360 |
| The Spirit of the Wolf | 2009 | wii |
| Splatterhouse | 2010 | ps3, xbox360 |
| Splinter Cell HD | 2011 | ps3 |
| SpongeBob HeroPants | 2015 | 3ds, vita |
| SpongeBob SquarePants: Battle for Bikini Bottom – Rehydrated | 2020 | ps4, switch, xboxone |
| SpongeBob SquarePants: The Cosmic Shake | 2023 | ps4, switch, xboxone |
| SpongeBob's Atlantis SquarePantis | 2007 | gba, nds |
| SpongeBob's Truth or Square | 2009 | nds, psp |
| Spooky's Jump Scare Mansion: HD Renovation | 2019 | ps4 |
| Spore Hero Arena | 2009 | nds |
| Spy Chameleon | 2014 | wiiu |
| Spyro - Shadow Legacy | 2005 | nds |