| SNK 40th Anniversary Collection | 2018 | ps4, switch |
| SPRay | 2008 | wii |
| Saboteur | 2018 | switch |
| Sacred Citadel | 2013 | ps3, xbox360 |
| Saint Seiya - Sanctuary Battle | 2012 | ps3 |
| Saint Seiya Senki | | ps3 |
| Saints - Seinaru Mamono | 2003 | ps2 |
| Saints Row | 2006 | xbox360 |
| Saints Row - Gat out of Hell | 2015 | ps3, ps4, xbox360, xboxone |
| Saints Row - The Third | 2011 | ps3, switch, xbox360 |
| Saints Row 2 | 2008 | ps3, xbox360 |
| Saints Row IV | 2013 | ps3, xbox360 |
| Saints Row IV - Ultra Super Ultimate Deluxe Edition | 2013 | xbox360 |
| Saints Row IV: Re-Elected | 2015 | ps4 |
| Saints Row IV: Re-Elected | 2015 | xboxone |
| Saints Row: The Third Remastered | 2020 | ps4 |
| Sam & Max Save the World | 2009 | xbox360 |
| Sam Power - Firefighter | 2004 | nds |
| Samurai Dou 3 | 2008 | ps3 |
| Samurai Dou 4 | 2011 | ps3 |
| Samurai Warriors - Chronicles | 2011 | 3ds |
| Samurai-dou 2 - Way of the Samurai 2 | 2003 | ps2 |
| Saru! Get You! P! | 2005 | psp |
| Sausage Sports Club | 2018 | switch |
| Save Me Mr Tako: Definitive Edition | 2021 | switch |
| Save the Kuin | 2023 | nes |
| Saw | 2009 | ps3, xbox360 |
| Saw II - Flesh & Blood | 2010 | ps3, xbox360 |
| Schizoid | 2008 | xbox360 |
| School of Darkness | 2009 | wii |
| The School: Swan Song | | ps4 |
| Schrödinger's Cat and The Raiders of The Lost Quark | 2015 | xboxone |
| Scooby-Doo & Looney Tunes Cartoon Universe - Adventure | 2014 | 3ds |
| Scooby-Doo! - First Frights | 2004 | nds, ps2, wii |
| Scooby-Doo! - Mystery Mayhem | 2003 | gba, gc, ps2, xbox |
| Scooby-Doo! - Who's Watching Who | 2004 | nds, psp |
| The Scorpion King - Rise of the Akkadian | 2002 | gc, ps2 |
| Screwjumper! | 2007 | xbox360 |
| Scribblenauts Unlimited | 2012 | 3ds, wiiu |
| Sea of Solitude: The Director's Cut | 2021 | switch |
| Sea of Thieves | 2018 | xboxone |
| Second Sight | 2004 | gc, ps2, xbox |
| Sekiro: Shadows Die Twice | 2019 | ps4, xboxone |
| Sengoku | 2013 | wii |
| Sengoku Denshou | | wii |
| Serial Cleaner | 2017 | ps4, switch, xboxone |
| Serial Cleaners | 2022 | switch |
| Serie de Catastroficas Desdichas de Lemony Snicket, Una | 2004 | gc, ps2 |
| Severed | 2016 | switch, vita, wiiu |
| Shadow Archer | 2016 | wiiu |
| Shadow Complex | 2009 | xbox360 |
| Shadow Complex Remastered | 2016 | ps4 |
| Shadow Man - 2econd Coming | 2002 | ps2 |
| Shadow Man Remastered | 2022 | ps4, switch, xboxone |
| Shadow Puppeteer | 2016 | wiiu |
| Shadow Walker - Kage no Shounen to Hikari no Yousei | 2009 | wii |
| Shadow of the Colossus | 2005 | ps2 |
| Shadow of the Colossus | 2011 | ps3 |
| Shadow of the Colossus | 2018 | ps4 |
| Shadow of the Ninja | 2015 | wiiu |
| Shadow of the Tomb Raider | 2018 | ps4, xboxone |
| A Shadow's Tale | 2016 | wiiu |
| Shadows of the Damned: Hella Remastered | 2024 | xboxone |
| Shakedown - Hawaii | 2019 | 3ds, ps4, switch, vita, wii, wiiu |
| Shakedown - Hawaii | | ps3 |
| Shaman King Card Game - Chou Senjiryakketsu 2 | 2002 | gba |
| Shank | 2010 | ps3, xbox360 |
| Shank 2 | 2012 | ps3, xbox360 |
| Shantae - Kaizoku no Noroi | 2015 | 3ds |
| Shantae - Risky's Revenge - Director's Cut | 2016 | wiiu |
| Shantae and the Pirate's Curse | 2014 | 3ds, ps4, switch, wiiu, xboxone |
| Shantae and the Seven Sirens | 2020 | ps4, switch, xboxone |
| Shantae: Risky's Revenge - Director's Cut | 2020 | switch, xboxone |
| Shapes of Gray | 2015 | wiiu |
| Shaun the Sheep - Off His Head | 2009 | nds |
| Shenmue | 2000 | dreamcast |
| Shenmue I & II | 2018 | ps4, xboxone |
| Shenmue II | 2001 | dreamcast, xbox |
| Shenmue III | 2019 | ps4 |
| Sherlock Holmes - The Silver Earring | 2011 | wii |
| Sherlock Holmes: Chapter One | 2022 | ps4 |
| The Shield - The Game | 2007 | ps2 |
| Shift Quantum | 2018 | switch |
| Shin Sangoku Musou - 2nd Evolution | 2006 | psp |
| Shin Seiki Evangelion - Battle Orchestra | 2007 | ps2 |
| Shinobi III - Return of the Ninja Master | 2007 | wii |
| Shinobido - Way of the Ninja | 2005 | ps2 |
| Shinobido 2 - Revenge of Zen | 2011 | vita |
| Shinobido Homura | 2007 | psp |
| Shinobido Takumi | 2006 | ps2 |
| Shinsekai: Into the Depths | 2020 | switch |
| Shonen Jump One Piece - Unlimited Adventure | 2007 | wii |
| Shoot Many Robots | 2012 | ps3, xbox360 |
| Shounen Kininden Tsumuji | 2010 | nds |
| Shrek - Forever After | 2010 | nds |
| Shrek 2 | 2004 | gba, gc, ps2, xbox |
| Shrek Tercero | 2007 | nds |
| Shrek Terzo | 2007 | nds |
| Shrek de Derde | 2007 | nds |
| Shrek der Dritte | 2007 | nds |