| Dead Angle | BR | 1989-11 |
Sega Enterprises | Commercial |
| Dead Angle | BR | 1989-11 |
Sega Enterprises | Prototype |
| Dead Angle | EU | 1990-01 |
Sega Enterprises | Commercial |
| Dead Angle | EU | 1990-01 |
Sega Enterprises | Prototype |
| Dead Angle | US | 1989-11 |
Sega Enterprises | Commercial |
| Dead Angle | US | 1989-11 |
Sega Enterprises | Prototype |
| Dead Gunner | WORLD | |
| Demo |
| Deep Duck Trouble Starring Donald Duck | BR | 1993 |
Sega Enterprises | Commercial |
| Deep Duck Trouble Starring Donald Duck | EU | 1994-01 |
Sega Enterprises | Commercial |
| Desert Speedtrap Starring Road Runner and Wile E. Coyote | BR | 1993 |
Sega Enterprises | Commercial |
| Desert Speedtrap Starring Road Runner and Wile E. Coyote | EU | 1993 |
Sega Enterprises | Commercial |
| Desert Strike | EU | 1993-11 |
Domark | Commercial |
| Dick Tracy | BR | 1990 |
Sega of America | Commercial |
| Dick Tracy | EU | 1991-04 |
Sega of America | Commercial |
| Dick Tracy | US | 1991-02 |
Sega of America | Commercial |
| Digger Ball | WORLD | |
| Unlicensed |
| Digger Chan | WORLD | 2006-12 |
Playgeneration | Prototype |
| Dinobasher Starring Bignose the Caveman | EU | |
Codemasters | Prototype |
| Do the Same | WORLD | 2024 |
Ricco59 | Demo |
| Doki Doki Penguin Land - Uchuu Daibouken | JP | 1987-08 |
Sega of America | Commercial |
| Doki Doki Penguin Land - Uchuu Daibouken | JP | 1987-08 |
Sega of America | Prototype |
| Domino | BR | 2007 |
Tec Toy | Commercial |
| Donkey | WORLD | 2021-01 |
raphnet | Unlicensed |
| Double Dragon | TW | 1988-10-01 |
Sega Enterprises | Unlicensed |
| Double Dragon | WORLD | 1988-10-01 |
Sega Enterprises | Commercial |
| Double Hawk | EU | 1990 |
Sega Enterprises | Commercial |
| Double Hawk | EU | 1990 |
Sega Enterprises | Prototype |
| Double Target - Cynthia no Nemuri | JP | 1987-01-18 |
Sega of America | Commercial |
| Doze Trabalhos de Jongo, Os | BR | |
| Commercial |
| Dr. HELLO | KR | 1991 |
Sis Co | Unlicensed |
| Dr. Robotnik's Mean Bean Machine | BR | 1993 |
Sega Enterprises | Commercial |
| Dr. Robotnik's Mean Bean Machine | EU | 1994-03 |
Sega Enterprises | Commercial |
| Dragon - The Bruce Lee Story | EU | 1994-09 |
Acclaim Entertainment | Commercial |
| Dragon Blaster | WORLD | |
| Prototype |
| Dragon Crystal | BR | 1991-11 |
Sega Enterprises | Commercial |
| Dragon Crystal | EU | 1991-11-21 |
Sega Enterprises | Commercial |
| Draw Poker | WORLD | |
| Prototype |
| Driar | WORLD | |
| Prototype |
| Duckslayer Adventures | WORLD | |
| Prototype |
| Dynamite Duke | BR | 1991-04 |
Sega Enterprises | Commercial |
| Dynamite Duke | EU | 1991-04 |
Sega Enterprises | Commercial |
| Dynamite Dux | BR | 1989 |
Sega Enterprises | Commercial |
| Dynamite Dux | BR | 1989 |
Sega Enterprises | Prototype |
| Dynamite Dux | EU | 1990-01 |
Sega Enterprises | Commercial |
| Dynamite Dux | EU | 1990-01 |
Sega Enterprises | Prototype |
| Dynamite Headdy | BR | 1995 |
Sega | Commercial |
| E-SWAT | BR | 1990-09 |
Sega of America | Commercial |
| E-SWAT | BR | 1990-09 |
Sega of America | Prototype |
| E-SWAT | EU | 1990-11 |
Sega of America | Commercial |
| E-SWAT | EU | 1990-11 |
Sega of America | Prototype |
| E-SWAT | US | 1990-09 |
Sega of America | Commercial |
| E-SWAT | US | 1990-09 |
Sega of America | Prototype |
| E.I. - Exa Innova | KR | |
HiCom | Unlicensed |
| Eagles 5 | KR | 1990 |
Zemina | Unlicensed |
| Earthworm Jim | BR | 1996 |
Shiny Entertainment | Commercial |
| Ecco - The Tides of Time | BR | 1996 |
Tec Toy | Commercial |
| Ecco the Dolphin | BR | 1993 |
Sega Enterprises | Commercial |
| Ecco the Dolphin | EU | 1994-08-24 |
Sega Enterprises | Commercial |
| Eggie Chuck | WORLD | |
| Prototype |
| Electronic Dreams | WORLD | 2023-10 |
SMS Power! | Prototype |
| Enduro Racer | BR | 1987-05 |
Sega of America | Commercial |
| Enduro Racer | EU | 1987-11 |
Sega of America | Commercial |
| Enduro Racer | JP | 1987-05-18 |
Sega of America | Commercial |
| Enduro Racer | US | 1987-08 |
Sega of America | Commercial |
| Escape from Monster Dimension | WORLD | |
| Prototype |
| Extreme Volleyball - Infernal League | WORLD | 2023 |
raphnet | Unlicensed |
| F-1 Spirit - The Way to Formula-1 | KR | 1987 |
Zemina | Unlicensed |
| F-16 Fighter | BR | 1986 |
Sega Enterprises | Commercial |
| F-16 Fighter | EU | 1986 |
Sega Enterprises | Commercial |
| F-16 Fighter | US | 1986 |
Sega Enterprises | Commercial |
| F-16 Fighting Falcon | JP | 1985-12-22 |
Sega Enterprises | Commercial |
| F-16 Fighting Falcon | TW | 1985-12 |
Sega Enterprises | Unlicensed |
| F-16 Fighting Falcon | US | 1986-10 |
Sega Enterprises | Commercial |
| F1 | BR | 1993-10 |
Domark | Commercial |
| F1 | EU | 1993-10 |
Domark | Commercial |
| FA Tetris | KR | 1990 |
FA Soft | Unlicensed |
| FIFA International Soccer | BR | 1994 |
EA Sports | Commercial |
| Fabrica de Chocolate | BR | 2007 |
Tec Toy | Commercial |
| Fairy Forest | WORLD | |
| Unlicensed |
| Family Games | JP | 1987-12-27 |
Sega of America | Commercial |
| Fantastic Dizzy | EU | 1993-10 |
Codemasters | Commercial |
| Fantasy Zone | JP | 1986-06-15 |
Sega of America | Commercial |
| Fantasy Zone | TW | 1986-06-15 |
Sega of America | Unlicensed |
| Fantasy Zone | WORLD | 1986-06-15 |
Sega of America | Prototype |
| Fantasy Zone | WORLD | 1986-06-15 |
Sega of America | Commercial |
| Fantasy Zone - The Maze | BR | 1987-12 |
Sega of America | Commercial |
| Fantasy Zone - The Maze | BR | 1987-12 |
Sega of America | Prototype |
| Fantasy Zone - The Maze | EU | 1988 |
Sega of America | Commercial |
| Fantasy Zone - The Maze | EU | 1988 |
Sega of America | Prototype |
| Fantasy Zone - The Maze | US | 1988-07 |
Sega of America | Commercial |
| Fantasy Zone - The Maze | US | 1988-07 |
Sega of America | Prototype |
| Fantasy Zone II | BR | 1987-10 |
Sega of America | Commercial |
| Fantasy Zone II | EU | 1987-10 |
Sega of America | Commercial |
| Fantasy Zone II | US | 1987-10 |
Sega of America | Commercial |
| Fantasy Zone II - Opa-Opa no Namida | JP | 1997-10 |
Sega of America | Commercial |
| Feiche Zhengba Zhan | TW | |
| Unlicensed |
| Ferias Frustradas do Pica Pau | BR | 1996-10 |
Tec Toy | Commercial |
| Final Bubble Bobble | JP | 1988-07-02 |
Sega Enterprises | Commercial |
| Find the Wordy Gems | WORLD | |
| Demo |
| Fire & Forget II | EU | 1990-11 |
Sega | Commercial |