| MSX Soccer | KR | |
| Unlicensed |
| Mahjong Sengoku Jidai | JP | 1987-10-18 |
Sega | Commercial |
| Mahjong Sengoku Jidai | JP | 1987-10-18 |
Sega | Prototype |
| Mahjong Solitaire | WORLD | |
| Unlicensed |
| Mai Nurse | WORLD | 2024-03 |
lunoka | Unlicensed |
| Makai Retsuden | JP | 1987-05-17 |
Sega | Commercial |
| Maou Golvellius | JP | 1988-08 |
Sega | Commercial |
| Maou Golvellius | JP | 1988-08 |
Sega | Prototype |
| Marble Madness | EU | 1992-08 |
Virgin | Commercial |
| Marksman Shooting & Trap Shooting | BR | 1986-12 |
Sega | Commercial |
| Marksman Shooting & Trap Shooting | US | 1986-12 |
Sega | Commercial |
| Marksman Shooting & Trap Shooting & Safari Hunt | EU | 1986 |
Sega | Commercial |
| Master of Darkness | BR | 1992 |
Sega | Commercial |
| Master of Darkness | EU | 1992 |
Sega | Commercial |
| Master of the Labyrinth | WORLD | |
| Demo |
| Masters of Combat | BR | 1993 |
Sega | Commercial |
| Masters of Combat | EU | 1994-03-10 |
Sega | Commercial |
| Maze Hunter 3-D | BR | 1988 |
Sega | Commercial |
| Maze Hunter 3-D | BR | 1988 |
Sega | Prototype |
| Maze Hunter 3-D | EU | 1988 |
Sega | Commercial |
| Maze Hunter 3-D | EU | 1988 |
Sega | Prototype |
| Maze Hunter 3-D | US | 1988 |
Sega | Commercial |
| Maze Hunter 3-D | US | 1988 |
Sega | Prototype |
| Maze Walker | JP | 1988-01-31 |
Sega | Commercial |
| Mazy | WORLD | |
| Unlicensed |
| Mazy 2 | WORLD | |
| Unlicensed |
| Mega Man II | WORLD | 2015-12 |
GVX32 | Prototype |
| Mega Mode Super Game 138 | KR | |
| Unlicensed |
| Mega Mode Super Game 30 | KR | |
| Unlicensed |
| Megumi Rescue | JP | 1988-07-30 |
Sega | Commercial |
| Memoria Master | BR | 2007 |
Tec Toy | Commercial |
| Mercs | BR | 1990 |
Sega | Commercial |
| Mercs | EU | 1992-01 |
Sega | Commercial |
| Michael Jackson's Moonwalker | BR | 1990 |
Sega | Commercial |
| Michael Jackson's Moonwalker | BR | 1990 |
Sega | Prototype |
| Michael Jackson's Moonwalker | EU | 1991-02 |
Sega | Commercial |
| Michael Jackson's Moonwalker | EU | 1991-02 |
Sega | Prototype |
| Michael Jackson's Moonwalker | TW | 1990 |
Sega | Unlicensed |
| Michael Jackson's Moonwalker | US | 1991-05 |
Sega | Demo |
| Michael Jackson's Moonwalker | US | 1991-05 |
Sega | Commercial |
| Michael Jackson's Moonwalker | US | 1991-05 |
Sega | Prototype |
| Mickey's Ultimate Challenge | BR | 1998 |
Tec Toy | Commercial |
| Micro Machines | EU | 1994-03-10 |
Codemasters | Commercial |
| Mieyen | WORLD | |
| Unlicensed |
| Mina Terrestre | BR | 2007 |
Tec Toy | Commercial |
| Mine Sweeper | WORLD | 2014-03 |
SMS Power! | Unlicensed |
| Minerador | BR | 2007 |
Tec Toy | Commercial |
| Minesweeper | WORLD | 2014-03 |
SMS Power! | Unlicensed |
| Mini MSX | WORLD | 2021-03 |
| Unlicensed |
| Miracle Warriors - Seal of The Dark Lord | BR | 1987-10 |
Sega | Commercial |
| Miracle Warriors - Seal of The Dark Lord | BR | 1987-10 |
Sega | Prototype |
| Miracle Warriors - Seal of The Dark Lord | EU | 1988-11 |
Sega | Commercial |
| Miracle Warriors - Seal of The Dark Lord | EU | 1988-11 |
Sega | Prototype |
| Miracle Warriors - Seal of The Dark Lord | US | 1988-10 |
Sega | Commercial |
| Miracle Warriors - Seal of The Dark Lord | US | 1988-10 |
Sega | Prototype |
| Missile Defense 3-D | BR | 1987-08 |
Sega | Commercial |
| Missile Defense 3-D | BR | 1987-10 |
Sega | Demo |
| Missile Defense 3-D | EU | 1987-10 |
Sega | Commercial |
| Missile Defense 3-D | EU | 1987-10 |
Sega | Demo |
| Missile Defense 3-D | US | 1987-08 |
Sega | Commercial |
| Missile Defense 3-D | US | 1987-08 |
Sega | Demo |
| Moggy Master | WORLD | 2015 |
The Mojon Twins | Unlicensed |
| Monaco Master | WORLD | 2023 |
Louis The SEGA Nerd | Unlicensed |
| Monica no Castelo do Dragao | BR | 1991-12 |
Tec Toy | Commercial |
| Monkey Lad | WORLD | 2024 |
| Prototype |
| Monopoly | EU | 1988-10 |
Sega | Commercial |
| Monopoly | EU | 1988-10 |
Sega | Prototype |
| Monopoly | US | 1988-09 |
Sega | Commercial |
| Monopoly | US | 1988-09 |
Sega | Prototype |
| Monster Crunch | WORLD | |
| Unlicensed |
| Montezuma's Revenge Featuring Panama Joe | US | 1989-06 |
Parker Brothers | Commercial |
| Montezuma's Revenge Featuring Panama Joe | US | 1989-06 |
Parker Brothers | Prototype |
| Mopiranger | KR | |
Konami | Unlicensed |
| Mortal Kombat | BR | 1993-09 |
Arena Entertainment | Commercial |
| Mortal Kombat | EU | 1993-09-13 |
Arena Entertainment | Commercial |
| Mortal Kombat 3 | BR | 1996 |
Tec Toy | Commercial |
| Mortal Kombat II | BR | 1994-11 |
Acclaim Entertainment | Commercial |
| Mortal Kombat II | EU | 1994-11 |
Acclaim Entertainment | Commercial |
| Move Your Feet | WORLD | |
| Demo |
| Ms. Pac-Man | BR | 1991 |
Tengen | Commercial |
| Ms. Pac-Man | EU | 1991 |
Tengen | Commercial |
| Ms. Pac-Man Classic | WORLD | 2025 |
| Unlicensed |
| My Hero | BR | 1986-01 |
Sega | Commercial |
| My Hero | EU | 1987-08 |
Sega | Commercial |
| My Hero | US | 1986-09 |
Sega | Commercial |