| Space Hawks | WORLD | |
| Prototype |
| Space Tonbow | WORLD | 2024-06 |
Steelfinger Studios | Unlicensed |
| Speccies 2 | WORLD | 2020-03 |
SMS Power! | Unlicensed |
| Special Criminal Investigation | EU | 1992-10-15 |
Taito | Commercial |
| Special Criminal Investigation | EU | 1992-10-15 |
Taito | Prototype |
| Speedball | EU | 1991-03 |
Virgin | Commercial |
| Speedball | WORLD | 1991-03 |
Image Works | Commercial |
| Speedball 2 | EU | 1992-10-29 |
Virgin Games | Commercial |
| SpellCaster | BR | 1988-09 |
Sega | Commercial |
| SpellCaster | EU | 1989 |
Sega | Commercial |
| SpellCaster | US | 1989-09 |
Sega | Commercial |
| Spider-Man | BR | 1990 |
Sega | Commercial |
| Spider-Man | EU | 1990 |
Sega | Commercial |
| Spider-Man | US | 1990 |
Sega | Commercial |
| Spider-Man - Return of the Sinister Six | BR | 1992 |
Flying Edge | Commercial |
| Spider-Man - Return of the Sinister Six | EU | 1993 |
Flying Edge | Commercial |
| Sports Pad Football | US | 1987 |
Sega | Commercial |
| Sports Pad Soccer | JP | 1987-07 |
Sega | Commercial |
| Spy vs Spy | BR | 1986-09 |
Sega | Commercial |
| Spy vs Spy | EU | 1987-08 |
Sega | Commercial |
| Spy vs Spy | JP | 1985-09 |
Sega | Commercial |
| Spy vs Spy | TW | 1986-09 |
Sega | Unlicensed |
| Spy vs Spy | US | 1988-10 |
Sega | Commercial |
| Stalactites | WORLD | 2026-03 |
SMS Power! | Prototype |
| Star Wars | BR | 1993-10 |
U.S. Gold | Commercial |
| Star Wars | EU | 1993-10 |
U.S. Gold | Commercial |
| Street Fighter II' | BR | 1997 |
Tec Toy | Commercial |
| Street Master | KR | 1992 |
Zemina | Unlicensed |
| Streets of Rage | BR | 1993-06 |
Sega | Commercial |
| Streets of Rage | EU | 1993-06-07 |
Sega | Commercial |
| Streets of Rage II | BR | 1993-12 |
Sega | Commercial |
| Streets of Rage II | EU | 1994-02 |
Sega | Commercial |
| Strider | BR | 1991-06 |
Sega | Commercial |
| Strider | EU | 1991-09 |
Sega | Commercial |
| Strider | US | 1991-06 |
Sega | Commercial |
| Strider II | BR | 1992 |
U.S. Gold | Commercial |
| Strider II | EU | 1993-04 |
U.S. Gold | Commercial |
| Stygian Quest | WORLD | 2024-09 |
Danara Games | Unlicensed |
| Sub Rescue | WORLD | |
| Prototype |
| Sub-Assault | WORLD | |
| Unlicensed |
| Submarine Attack | BR | 1990 |
Sega | Commercial |
| Submarine Attack | EU | 1990 |
Sega | Commercial |
| Submarine Attack | TW | 1990 |
Sega | Unlicensed |
| Sudoku | BR | 2007 |
Tec Toy | Commercial |
| Sudoku | WORLD | 2007 |
Tec Toy | Prototype |
| Suho Jeonsa | KR | 1994 |
Open Corp | Unlicensed |
| Sukeban Deka II - Shoujo Tekkamen Densetsu | JP | 1987-04 |
Sega | Commercial |
| Summer Games | BR | 1991 |
Sega | Commercial |
| Summer Games | BR | 1991 |
Sega | Prototype |
| Summer Games | EU | 1991 |
Sega | Commercial |
| Summer Games | EU | 1991 |
Sega | Prototype |
| Super Arkanoid | KR | 1990 |
Sega | Unlicensed |
| Super Basketball | US | 1990 |
Sega | Demo |
| Super Bioman I | KR | 1992-12 |
HiCom | Unlicensed |
| Super Boy 4 | KR | 1992 |
Zemina | Unlicensed |
| Super Boy I | KR | 1989 |
Zemina | Unlicensed |
| Super Boy II | KR | 1989 |
Zemina | Unlicensed |
| Super Boy III | KR | 1991 |
Zemina | Unlicensed |
| Super Bubble Bobble | KR | 1989 |
Zemina | Unlicensed |
| Super Columns & Tetris | KR | 1990 |
HiCom | Unlicensed |
| Super Futebol II | BR | 1990 |
Sega | Commercial |
| Super Game 150 | KR | |
| Unlicensed |
| Super Game 180 | KR | |
| Unlicensed |
| Super Game 45 | KR | |
| Unlicensed |
| Super Game 52 Hap | KR | |
| Unlicensed |
| Super Game World 30 Hap | KR | |
| Unlicensed |
| Super Game World 75 Hap | KR | |
| Unlicensed |
| Super Golf | EU | 1989 |
Sega | Prototype |
| Super Kick Off | BR | 1991-12 |
U.S. Gold | Commercial |
| Super Kick Off | EU | 1991-12 |
U.S. Gold | Commercial |
| Super Monaco GP | BR | 1990-09 |
Sega | Commercial |
| Super Monaco GP | BR | 1990-09 |
Sega | Prototype |
| Super Monaco GP | EU | 1990-09 |
Sega | Commercial |
| Super Monaco GP | EU | 1990-09 |
Sega | Prototype |
| Super Monaco GP | US | 1990-09 |
Sega | Commercial |
| Super Monaco GP | US | 1990-09 |
Sega | Prototype |
| Super Multi Game - Super 125 in 1 | KR | |
| Unlicensed |
| Super Multi Game - Super 75 in 1 | KR | |
| Unlicensed |
| Super Off Road | EU | 1992 |
Virgin | Prototype |
| Super Off Road | EU | 1993-09 |
Virgin | Commercial |
| Super Penguin | KR | |
| Unlicensed |
| Super Racing | JP | 1988-07-02 |
Sega | Commercial |
| Super Smash T.V | EU | 1992 |
Flying Edge | Commercial |
| Super Space Invaders | EU | 1992-06-24 |
Domark | Commercial |
| Super Tennis | EU | 1987-08 |
Sega | Commercial |
| Super Tennis | US | 1986-12 |
Sega | Commercial |
| Super Tetris | TW | |
| Unlicensed |
| Super Wild War '22 | WORLD | |
| Unlicensed |
| Super Wonder Boy - Monster World | JP | 1988-01-31 |
Sega | Commercial |
| Superman - The Man of Steel | BR | 1993-06 |
Virgin | Commercial |
| Superman - The Man of Steel | EU | 1993-06 |
Virgin | Commercial |
| Sushi Nights | WORLD | 2024-12 |
toxa | Unlicensed |
| Sutoroku | WORLD | |
| Prototype |
| Svellas | WORLD | |
| Unlicensed |
| Sword Strike | WORLD | |
| Prototype |
| Sydney Hunter - The Sacred Tribe | WORLD | 2019-07 |
CollectorVision | Unlicensed |