| Bashi Bazook - Morphoid Masher | US | 1988 |
Jaleco | Prototype |
| Dracula II - Noroi no Fuuin | AS | 1988 |
| Unlicensed |
| Hard Drivin' | US | 1988 |
Tengen | Prototype |
| Mi Hun Che | TW | 1988 |
RCM Group | Unlicensed |
| Pachio-kun 2 | JP | 1988 |
Coconuts Japan | Commercial |
| Pinuocao de Fusu | CN | 1988 |
Fuzhou Waixing Computer Science & Technology | Unlicensed |
| Shui Guo Li | AS | 1988 |
| Unlicensed |
| Shui Guo Li | TW | 1988 |
Home Entertainment Suppliers | Unlicensed |
| Strider Hiryu | JP | 1988 |
Capcom | Prototype |
| Super Car | TW | 1988 |
RCM Group | Unlicensed |
| Vindicators | US | 1988 |
Tengen | Unlicensed |
| Fisraduth - Castle of Tyramis | JP | 1988-01 |
Dempa Shinbunsha | Unlicensed |
| Karnov | US | 1988-01 |
Data East | Commercial |
| Renegade | US | 1988-01 |
Taito | Commercial |
| Renegade | US | 1988-01 |
Taito | Prototype |
| Satsui no Kaisou - Soft House Renzoku Satsujin Jiken | JP | 1988-01 |
HAL Laboratory | Commercial |
| Family Circuit | JP | 1988-01-06 |
Namco | Commercial |
| Konami Wai Wai World | JP | 1988-01-14 |
Konami | Commercial |
| Highway Star | RU | 1988-01-15 |
| Unlicensed |
| Metroid | EU | 1988-01-15 |
Nintendo | Commercial |
| Rad Racer | EU | 1988-01-15 |
Sega | Commercial |
| Sukeban Deka III | JP | 1988-01-22 |
Toei Animation | Commercial |
| Ripple Island | JP | 1988-01-23 |
Sunsoft | Commercial |
| Ripple Island | WORLD | 1988-01-23 |
Sunsoft | Commercial |
| Donald Land | JP | 1988-01-29 |
Data East | Commercial |
| Astro Boy | WORLD | 1988-02 |
| Unlicensed |
| Gun.Smoke | AS | 1988-02 |
| Unlicensed |
| Gun.Smoke | US | 1988-02 |
Capcom | Commercial |
| Gun.Smoke | US | 1988-02 |
Capcom | Prototype |
| Kamen Rider Club | JP | 1988-02 |
Bandai | Commercial |
| Karaoke Studio Senyou Cassette - Top Hit 20 Vol. 2 | JP | 1988-02 |
Bandai | Commercial |
| R.C. Pro-Am | US | 1988-02 |
Nintendo | Commercial |
| Tantei Jinguuji Saburou - Yokohamakou Renzoku Satsujin Jiken | JP | 1988-02 |
Data East | Commercial |
| Town & Country Surf Designs - Wood & Water Rage | US | 1988-02 |
LJN | Commercial |
| Jumbo Ozaki no Hole in One Professional | JP | 1988-02-01 |
HAL Laboratory | Commercial |
| Paris-Dakar Rally Special | JP | 1988-02-03 |
CBS Sony Group | Commercial |
| Guardic Gaiden | JP | 1988-02-05 |
Nintendo | Commercial |
| Guardic Gaiden | JP | 1988-02-05 |
Irem | Prototype |
| Contra | AS | 1988-02-09 |
| Unlicensed |
| Contra | WORLD | 1988-02-09 |
Konami | Commercial |
| Dragon Quest III - Soshite Densetsu e | JP | 1988-02-10 |
Enix | Commercial |
| Contra | US | 1988-02-12 |
Konami | Commercial |
| Tetsuwan Atom | JP | 1988-02-26 |
Konami | Commercial |
| Arkanoid II | JP | 1988-03 |
Taito | Commercial |
| Arkanoid II | JP | 1988-03 |
Taito | Prototype |
| Be-Bop-Highschool - Koukousei Gokuraku Densetsu | JP | 1988-03 |
Data East | Commercial |
| Dragon Power | US | 1988-03 |
Bandai | Commercial |
| Fudou Myouou Den | JP | 1988-03 |
Taito | Commercial |
| Golgo 13 - Daiisshou - Kamigami no Tasogare | JP | 1988-03 |
Vic Tokai | Commercial |
| Ice Hockey | US | 1988-03 |
Nintendo | Commercial |
| Nobunaga no Yabou - Zenkoku Ban | JP | 1988-03 |
Koei | Commercial |
| Olympus no Tatakai | JP | 1988-03 |
Brøderbund Software | Commercial |
| Tanigawa Kouji no Shougi Shinan II | JP | 1988-03 |
Pony Canyon | Commercial |
| Tsuri Kichi Sanpei - Blue Marlin Hen | JP | 1988-03 |
Victor Interactive Software | Commercial |
| Ballblazer | JP | 1988-03-04 |
Pony Canyon | Commercial |
| Predator | BR | 1988-03-10 |
Pack-In-Video | Unlicensed |
| Predator | JP | 1988-03-10 |
Activision | Commercial |
| Napoleon Senki | JP | 1988-03-18 |
Irem | Commercial |
| Fighting Golf | JP | 1988-03-24 |
SNK | Commercial |
| Takeda Shingen | JP | 1988-03-28 |
Hot-B | Commercial |
| Fleet Commander | JP | 1988-03-29 |
ASCII Corporation | Commercial |
| Dokuganryuu Masamune | JP | 1988-04 |
Namco | Commercial |
| Freedom Force | US | 1988-04 |
Sunsoft | Commercial |
| Freedom Force | US | 1988-04 |
Sunsoft | Prototype |
| Ikari II - Dogosoken | JP | 1988-04 |
SNK | Commercial |
| Ikari Warriors II - Victory Road | US | 1988-04 |
SNK | Commercial |
| Jekyll Hakase no Houma ga Toki | JP | 1988-04 |
Bandai | Commercial |
| Major League Baseball | US | 1988-04 |
LJN | Commercial |
| Double Dragon | JP | 1988-04-08 |
Tradewest | Commercial |
| Double Dragon | JP | 1988-04-08 |
Tradewest | Prototype |
| Double Dragon | WORLD | 1988-04-08 |
Technōs Japan | Commercial |
| Ice Hockey | EU | 1988-04-15 |
Nintendo | Commercial |
| Moero!! Pro Tennis | JP | 1988-04-15 |
Jaleco | Commercial |
| R.C. Pro-Am | EU | 1988-04-15 |
Nintendo | Commercial |
| Captain Tsubasa | JP | 1988-04-28 |
Tecmo | Commercial |
| Elysion | JP | 1988-04-28 |
Tokuma Shoten | Commercial |
| Sensha Senryaku - Sabaku no Kitsune | JP | 1988-04-28 |
Kemco | Commercial |
| City Connection | EU | 1988-05 |
Jaleco | Commercial |
| City Connection | US | 1988-05 |
Jaleco | Commercial |
| Deep Dungeon III - Yuushi e no Tabi | JP | 1988-05 |
Square | Commercial |
| Ninja-kun - Ashura no Shou | JP | 1988-05 |
UPL | Commercial |
| Rambo | US | 1988-05 |
Acclaim Entertainment | Commercial |
| Saint Seiya - Ougon Densetsu Kanketsu Hen | JP | 1988-05 |
Bandai Namco | Commercial |
| Saint Seiya - Ougon Densetsu Kanketsu Hen | JP | 1988-05 |
Bandai Namco | Prototype |
| Meitantei Holmes - Kiri no London Satsujin Jiken | JP | 1988-05-13 |
Towa Chiki | Commercial |
| Kamen no Ninja - Akakage | JP | 1988-05-20 |
Toei Animation | Commercial |
| Namco Classic | JP | 1988-05-27 |
Namco | Commercial |
| Shogun | JP | 1988-05-27 |
HectorSoft | Commercial |
| 1943 | JP | 1988-06 |
Capcom | Commercial |
| Back to the Future IV | AS | 1988-06 |
| Unlicensed |
| Chou-Wakusei Senki - MetaFight | JP | 1988-06 |
Sunsoft | Commercial |
| Double Dragon | US | 1988-06 |
Tradewest | Commercial |
| Kyuukyoku Harikiri Stadium | JP | 1988-06 |
Taito | Commercial |
| Metal Gear | US | 1988-06 |
Konami | Commercial |
| R.B.I. Baseball | US | 1988-06 |
Namco | Commercial |
| Rainbow Islands - The Story of Bubble Bobble 2 | JP | 1988-06 |
Taito | Commercial |
| Rainbow Islands - The Story of Bubble Bobble 2 | JP | 1988-06 |
Taito | Demo |
| Sanada Juu Yuushi | JP | 1988-06 |
Kemco | Commercial |
| Youkai Douchuuki | JP | 1988-06 |
Namco | Commercial |
| Cosmo Police Galivan | JP | 1988-06-03 |
Nichibutsu | Commercial |